Multilocus analysis of hormonal, neurotransmitter, inflammatory pathways and genome‐wide associated variants in migraine susceptibility

Abstract

The present study suggests interactions amongst hormonal, inflammatory and genome-wide associated variants but not with neurotransmitter pathway variants in migraine susceptibility.

Effects of MTHFR C677T and A1298C Polymorphisms on Migraine Susceptibility: A Meta‐Analysis of 26 Studies

“…(3) reviews, meta-analyses, or case reports; (4) studies evaluating other gene polymorphisms and migraine; (5) duplicate publications; (6) studies conducted in patients affected with known migraine concomitant neurological or psychiatric diseases.…”

“…Listed as the sixth most disabling disorder globally by the World Health Organization, migraine causes a huge economic because it mostly affects productive individuals . Although the pathogenesis of migraine is not fully understood, it is commonly acknowledged that both genetic backgrounds and environmental factors play important roles . Researchers have reported some gene polymorphisms possibly involved in migraine, including brain‐derived neurotrophic factor (BDNF), angiotensin‐converting enzyme (ACE) D/I and estrogen receptor 1 (ESR1) gene polymorphisms .…”

“…4 Although the pathogenesis of migraine is not fully understood, it is commonly acknowledged that both genetic backgrounds and environmental factors play important roles. 5,6 Researchers have reported some gene polymorphisms possibly involved in migraine, including brain-derived neurotrophic factor (BDNF), angiotensin-converting enzyme (ACE) D/I and estrogen receptor 1 (ESR1) gene polymorphisms. [7][8][9] And more studies reported that 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms were involved in migraine.…”

Chronic Migraine

“…27 It may well be that there are multiple normally expressed genes in the human genome with the potential to increase or decrease neuronal excitability, based on whether or not they are actively functioning. Entertaining the possibility that environmental factors may be able to modify gene expression, neurobiologists and geneticists have begun seeking explanations for the "genetic" nature of migraine and the predicted hyperexcitable nervous system by asking an age-old question: "To what extent does nurture vs nature play a role in predisposing a person to migraine?…”

Neurology in evolution 2014–2015

“…Headache is probably the commonest neurological problem and is responsible for very significant reduction in quality of life and has major economic consequences [153][154][155][156][157][158][159][160][161][162][163][164][165][166][167][168][169]. Genetic associations in migraine and in analgesic overuse headache are providing some insight into causation, but genetic factors remain complex, with relatively few single gene causes.…”