Replication of Migraine GWAS Susceptibility Loci in Chinese Han Population

Abstract

Our study confirmed the association of PRDM16 to migraine susceptibility in the Chinese Han population. The results also indicated that replication studies of previous GWAS findings across populations is of importance to validate these associations and to gain a better understanding of migraine susceptibility of potential genetic heterogeneity between populations. Further work is necessary to understand the functional mechanisms underlying these variants identified by GWAS.

Multilocus analysis reveals three candidate genes for Chinese migraine susceptibility

“…PRDM16 , which was previously identified as a risk factor for patients with MO in a relatively small‐scale sample, was also suggested to be associated with MO in the present expanded sample size study . Additionally, replication in genetic association studies of PRDM16 rs2651899 has been found in populations from western China, North Indian and Spain . This result further highlights the fact that the pathogenesis of migraine occurs without regard to race.…”

Diamine Oxidase rs10156191 and rs2052129 Variants Are Associated With the Risk for Migraine

“…Finally, Chasman et al described association between SNPs in the PRMD16 , TRPM8 , and LRP1 genes. Recent studies identified association between an SNP in the SLC39A12 gene and the risk for migraine or MWoA in different populations, but failed to find association with SNPs in the GALNT16 gene . In addition, interethnic variability in the associations exists, as LRP1 was found to be associated with the risk for migraine in Indians, but not in Chinese or Swedish individuals …”

“…Recent studies identified association between an SNP in the SLC39A12 gene and the risk for migraine 4,5,10 or MWoA 4,11 in different populations, but failed to find association with SNPs in the GALNT16 gene. 4,5,10,11 In addition, interethnic variability in the associations exists, as LRP1 was found to be associated with the risk for migraine in Indians, 4 but not in Chinese 10,11 or Swedish individuals. 5 Regarding genetic studies based on mechanistic hypothesis, histamine seems to be a plausible candidate involve in the etiology or in the clinical presentation of migraine.…”

Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine

“…Interestingly, this connection seems to be present only for individuals of Northern European ancestry [38,39,40,41,42], as studies involving populations from Spain, India, and China found either no association or weak associations between migraine incidence and SNPs near the TRPM8 locus [43,44,45,46,47]. …”