A Rare Presentation of Inflammatory Myofibroblastic Tumor in the Nasolabial Fold

Abstract

Inflammatory myofibroblastic tumor (IMT) is a benign lesion that occurs most frequently in the soft tissues and viscera. In the head and neck region, the tumor has been reported to occur in the orbit, tongue, nasopharynx, larynx, and paranasal sinuses and the central nervous system. Despite being a benign lesion, it exhibits infiltrative and destructive behaviours, making histopathological examination necessary to confirm the diagnosis. We report the case of a 38-year-old female presented with a right nasolabial fold mass, which was confirmed histologically to be an IMT. Surgical excision of the mass was achieved through a sublabial approach with an uneventful postoperative period. To the best of our knowledge, this is the first reported case of an IMT in the nasolabial fold.

Inflammatory Myofibroblastic Tumor: A Rare Presentation and an Effective Treatment with Crizotinib

“…IMT located in the head and neck regions is tremendously rare. From the extrapulmonary cases, 11% have been found in the upper respiratory tract, involving larynx, trachea, oropharynx, and nasopharynx around 5% of the cases involve the orbits, paranasal sinuses, major salivary glands, thyroid, and soft tissue in descending order of frequency [ 2 ]. To the best of our knowledge, this is the first subcutaneous IMT reported in this location.…”

“…IMT was previously believed to be benign inflammatory lesions, but more recently, their neoplastic origin is invariably accepted due to their high rate of local recurrence, distant metastasis, and acquired chromosomal abnormalities. Due to these characteristics, the World Health Organization (WHO) states an IMT as an intermediate soft tissue tumor that is composed of myofibroblast-differentiated spindle cells accompanied by numerous inflammatory cells, plasma cells, and/or lymphocytes [ 2 ].…”

Inflammatory pseudo-tumour of the colon mimicking acute appendicitis: A case report

“…This case report complies with the SCARE guidelines and has been reported in line with the SCARE checklist [1] . Inflammatory pseudo-tumours (IPTs) are rare mesenchymal masses that occur in <0.0001% of the population [2] , [3] , [4] . First described as IPTs in 1954 by Uniker and Iversion [4] , these tumours are benign lesions associated with non-specific inflammatory cellular infiltration with spindle-cell proliferation and are often reactive, infective, or immunological in nature [5] .…”

“…Inflammatory pseudo-tumours (IPTs) are rare mesenchymal masses that occur in <0.0001% of the population [2] , [3] , [4] . First described as IPTs in 1954 by Uniker and Iversion [4] , these tumours are benign lesions associated with non-specific inflammatory cellular infiltration with spindle-cell proliferation and are often reactive, infective, or immunological in nature [5] . They have been described predominantly in the lungs to date; however, they may occur in any anatomical location, mostly in children and young adults [2] , [3] , [4] .…”

“…First described as IPTs in 1954 by Uniker and Iversion [4] , these tumours are benign lesions associated with non-specific inflammatory cellular infiltration with spindle-cell proliferation and are often reactive, infective, or immunological in nature [5] . They have been described predominantly in the lungs to date; however, they may occur in any anatomical location, mostly in children and young adults [2] , [3] , [4] . Alimentary tract IPTs were first described in the stomach; however, they remain exceedingly rare, particularly in the colon, where their aetiology remains unclear [2] , [3] , [6] .…”