A randomized double-blind trial on perioperative administration of probiotics in colorectal cancer patients

Abstract

La1, but not BB536, adheres to the colonic mucosa, and affects intestinal microbiota by reducing the concentration of pathogens and modulates local immunity.

Probiotics as a preventive strategy for surgical infection in colorectal cancer patients: a systematic review and meta-analysis of randomized trials

“…Administration of probiotics in these patients aims a competitive action against bacteria responsible for postoperative inflammation (9). Thus, it has been suggested that probiotics play an essential role in the stability of the microbiological environment (10,11).…”

275 The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention

“…Although the results of systematic and wellcontrolled clinical studies in CRC prevention are not yet available, published reports suggest cautious optimism. [58][59][60] Although our study design does not address causality, it is plausible that curcumin contributes to chemoprevention via expansion of the native Lactobacilli in the context of overall increase of colonic microbiome richness. Similar effects may be ascribed to increased Bifidobacteria, which have also been shown to reduce aberrant crypt foci in mice receiving dimethylhyrazine.…”

A clinical primer of the role of gut microbiome in health and disease

“…Lactobacillus johnsonii and Lactobacillus casei suppress CRC tumor growth in patients and modulate the intestinal immune response. 110,111 Antibiotics have long been used to eradicate H pylori in the upper GI tract, and treatment is associated with a significant reduction in gastric Another growing area of interest is in modulating the gut microbiota to prevent toxicity associated with the chemotherapy and radiation used to treat cancer. A recent study identified the role of bacterial beta-glucuronidase in mediating GI toxicity of a common drug used for colon cancer CPT-11.…”