Probiotics as a preventive strategy for surgical infection in colorectal cancer patients: a systematic review and meta-analysis of randomized trials

Calaça, Priscilla Régia de Andrade; Bezerra, Raquel Pedrosa; Albuquerque, Wendell; Porto, Ana Lúcia Figueiredo; Cavalcanti, Maria Taciana Holanda

doi:10.21037/tgh.2017.08.01

Cited by 21 publications

(11 citation statements)

References 34 publications

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“…In a systemic review and meta-analysis of randomized trials, it was claimed that probiotics could prevent inflammation in the post-operative care of colorectal cancer patients, and they would be beneficial for surgical recovery. 51 Another systemic review and meta-analysis confirmed that the administration of probiotics reduced by almost half the infection rate and the incidence of pneumonia. 52 To sum up, probiotics may be used as a therapeutic method to prevent infections in patients with colorectal cancer in the postoperative period.…”

Section: Modification Of Gut Microbiota In Crc – Therapeutic Methodsmentioning

confidence: 96%

Therapeutic methods of gut microbiota modification in colorectal cancer management – fecal microbiota transplantation, prebiotics, probiotics, and synbiotics

Kaźmierczak-Siedlecka

et al. 2020

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The link between gut microbiota and the development of colorectal cancer has been investigated. An imbalance in the gut microbiota promotes the progress of colorectal carcinogenesis via multiple mechanisms, including inflammation, activation of carcinogens, and tumorigenic pathways as well as damaging host DNA. Several therapeutic methods are available with which to alter the composition and the activity of gut microbiota, such as administration of prebiotics, probiotics, and synbiotics; these can confer various benefits for colorectal cancer patients. Nowadays, fecal microbiota transplantation is the most modern way of modulating the gut microbiota. Even though data regarding fecal microbiota transplantation in colorectal cancer patients are still rather limited, it has been approved as a clinical method of treatment-recurrent Clostridium difficile infection, which may also occur in these patients. The major benefits of fecal microbiota transplantation include modulation of immunotherapy efficacy, amelioration of bile acid metabolism, and restoration of intestinal microbial diversity. Nonetheless, more studies are needed to assess the long-term effects of fecal microbiota transplantation. In this review, the impact of gut microbiota on the efficiency of anti-cancer therapy and colorectal cancer patients' overall survival is also discussed.

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Section: Modification Of Gut Microbiota In Crc – Therapeutic Methodsmentioning

confidence: 96%

Therapeutic methods of gut microbiota modification in colorectal cancer management – fecal microbiota transplantation, prebiotics, probiotics, and synbiotics

Kaźmierczak-Siedlecka

et al. 2020

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“…Additionally, probiotic or synbiotic supplementation improved the microbiota by increasing the Lactobacillus and reducing the Enterobacteriaceae members, but no significant changes were observed in length of hospital stay, incision and perineal infection, septic morbidity, and anastomotic leak [66]. Some of the recent metaanalysis studies revealed that the supplementation of probiotic preparations consists of Lactobacillus strains effectively reducing the surgical inflammation and promoting the surgical recovery in CRC patients [67], and the probiotic supplementation also effectively reduced the postoperative infection and complications such as incision infection, pneumonia, and flatus time [68] and also improved the intestinal mucosal barrier function in CRC patients [69].…”

Section: Clinical Trialsmentioning

confidence: 99%

The Role of Probiotics in Colorectal Cancer Management

Sivamaruthi

Kesika

Chaiyasut

2020

Evidence-Based Complementary and Alternative Medicine

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Colorectal cancer (CRC) is one of the most common cancerous diseases worldwide and causes leading cancer-associated deaths. Several factors are related to the incidence of CRC such as unhealthy diet and lifestyle, heredity, metabolic disorders, and genetic factors. Even though several advanced medical procedures are available for CRC treatment, the survival rates are poor with many adverse treatments associated side effects, which affects the quality of life. Probiotics are a well-known bioactive candidate for the treatment of several diseases and ill-health conditions. e recent scientific evidence suggested that probiotic supplementation protects the CRC patients from treatment-associated adverse effects. e manuscript summarizes the influence of probiotic supplementation on the health status of CRC patients and discusses the possible mechanism behind the protective effect of probiotics against CRC. e literature survey revealed that beneficial impact of probiotic supplementation depends on several factors such as strain, dosage, duration of the intervention, host physiology, and other food supplements. e probiotic intervention improves the microbiota, releases antimicrobials and anticarcinogenic agents, helps to remove carcinogens, and improves the intestinal permeability, tight junction function, and enzyme activity in CRC patients. Besides, not all probiotic strains exhibit anti-CRC activities; it is necessary to screen the potent strain for the development of a probiotic-based therapeutic agent to control or prevent the incidence of CRC.

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“…According to past studies, probiotics can inhibit colorectal cancer initiation or progression through change of intestinal microbial compounds, protection against pathogens, production of biological components, such as short-chain fatty acid, inactivation of carcinogenic compounds, regulation of immune responses, apoptosis induction, anti-proliferative activity, and antioxidant properties (16)(17)(18)(19). The study of Lee et al demonstrated that LAB plays an important role in the host immune system to produce anti-tumor effects (20,21).…”

Section: Discussionmentioning

confidence: 99%

Anti-Proliferative Effects of Two New Lactobacillus Strains of Human Origin on Caco-2 Cell Line

Arian

Kaboosi

Heshmatipour

et al. 2019

Iran Red Crescent Med J

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Background: Anti-proliferative effects of probiotics are considerable in the treatment of various cancers, including colon cancer. In the present study, two new Lactobacillus strains as probiotics were isolated from stool samples at a clinical lab. Objectives: The aim of this study was to evaluate the effects of the cell-free lyophilized filtrate of two new strains of Lactobacillus, isolated on viability on Caco-2 cells. Methods: Two new strains of Lactobacillus were isolated from 1 gr of each infant stool specimens from a total of fifty volunteers, according to the principles of a scientific questionnaire. The anti-proliferative effects of the strains were investigated using the MTT assay with Caco-2 cell lines. Results: Out of 50 samples, seven isolates were lactic acid bacteria, two strains of which were probiotics related to L. fermentum (E) and L. rhamnosus (G). The results showed that the two Lactobacillus strains had good anti-proliferative effects against the cancer cell lines tested. These strains were resistant to low pH and 0.3% bile salt. Cytotoxicity assay revealed that the most effective concentration of strains E (~55% to~72%) and G (~60% to~80%) on Caco-2 cells was 10000 µg/mL after 24 to72 hours. Conclusions: Cytotoxicity effect of the cell-free lyophilized filtrate of bacteria on Caco-2 cells in a dose-and time-dependent manner suggested that these strains might be used in colon cancer therapy.

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Probiotics as a preventive strategy for surgical infection in colorectal cancer patients: a systematic review and meta-analysis of randomized trials

Cited by 21 publications

References 34 publications

Therapeutic methods of gut microbiota modification in colorectal cancer management – fecal microbiota transplantation, prebiotics, probiotics, and synbiotics

Therapeutic methods of gut microbiota modification in colorectal cancer management – fecal microbiota transplantation, prebiotics, probiotics, and synbiotics

The Role of Probiotics in Colorectal Cancer Management

Anti-Proliferative Effects of Two New Lactobacillus Strains of Human Origin on Caco-2 Cell Line

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