Single-event effects (SEEs) have been the primary concern in study of radiation effects since late 1970s with the discovery of soft errors in terrestrial and space environments. The interaction of a single ionized particle with electronic devices leads to SEEs. In this paper, single-event upset (SEU) on CMOS devices in designing of a voltage-controlled oscillator (VCO) is analysed. Further, mitigation approaches of SEU are also discussed. To observe the impact of radiation, a VCO was designed in Cadence Virtuoso, and GDSII file of one ring oscillator stage was extracted to incorporate the same design in Silvaco MaskViews. With the help of layer map information file, masks were identified and used to design the CMOS inverter structure file for simulation of SEU condition. The input parameters for SEU simulation were evaluated from linear energy transfer (LET) graph of heavy ion under space conditions. The current profile of CMOS inverter was extracted under influence of a high-energy particle with the help of LET graph of that particle. This current profile was applied to different nodes of VCO and upset conditions were identified. Further, the impact of upset conditions on lock stage of phase-locked loop (PLL) is discussed. Results show that the SEU has significant impact on the logic state of inverters used in ring oscillator stage compared with current starving/biasing stage. The current profile of CMOS device has strong dependence on the energy of ion, its track, angle of incidence and the material. When angle of incidence is very less (7 À 14) the channel will be occupied by a funnel of charge and it leads to the maximum degradation of device. This work shows that a device operating at high frequency is more susceptible to SEU. Triple modular redundancy (TMR) and Radiation Hardened By Design (RHBD) can be used to mitigate SEU. TMR consumes more power and is less accurate compared with the RHBD approach.