A prospective study on the association between red hair color and endometriosis in infertile patients

Woodworth, Steven H.; Singh, Manvinder; Yussman, Marvin A.; Sanfilippo, Joseph S.; Cook, Christine L.; Lincoln, Stephen R.

doi:10.1016/s0015-0282(16)57809-1

Cited by 45 publications

(19 citation statements)

References 5 publications

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“…12 More recently, using updated data from their prospective study, the same group described a nonsignificant positive association between melanoma risk and endometriosis among red-haired women, but not among non-red-haired women, and a significant association between endometriosis and red hair, 5 as previously reported in the literature. 13 In our cohort, endometriosis was associated with red hair, but the test of an interaction between red hair and endometriosis on the risk of melanoma was not statistically significant. Several authors have hypothesized susceptibility to endometriosis in red-haired women via altered coagulation or a deficient immune system.…”

Section: Commentcontrasting

confidence: 56%

Personal History of Endometriosis and Risk of Cutaneous Melanoma in a Large Prospective Cohort of French Women

Kvaskoff

Mesrine²,

Fournier³

et al. 2007

Arch Intern Med

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Section: Commentcontrasting

confidence: 56%

Personal History of Endometriosis and Risk of Cutaneous Melanoma in a Large Prospective Cohort of French Women

Kvaskoff

Mesrine²,

Fournier³

et al. 2007

Arch Intern Med

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“…Endometriosis risk has been associated with melanoma risk factors known to be of genetic origin: red hair (11, 13, 38, 39), freckling (27, 40), number of naevi (13, 14, 26, 27), skin sensitivity to sun exposure (26, 27, 40, 41), and eye colour (40, 42). This may suggest that endometriosis and melanoma share common genetic factors, possibly involving a pigmentation pathway.…”

Section: Discussionmentioning

confidence: 99%

Endometriosis and the risk of skin cancer: a prospective cohort study

Farland

Lorrain

Missmer

et al. 2017

Cancer Causes Control

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Purpose Endometriosis has been associated with an increased risk of skin melanoma. However, associations with other skin cancer types and how they compare with melanoma are unclear. Our objective was to prospectively investigate the relationships between endometriosis and risk of non-melanoma and melanoma skin cancers. Methods E3N is a prospective cohort of 98,995 French women aged 40–65 years in 1990. Data on surgically-confirmed endometriosis and skin cancer diagnoses were collected every 2–3 years through self-report, with skin cancer cases confirmed through pathology reports. Hazard Ratios (HR) and 95% confidence intervals (CIs) were calculated using Cox regression models. Results Between 1990 and 2008, 535 melanoma, 247 squamous-cell carcinoma (SCC), and 1,712 basal-cell carcinoma (BCC) cases were ascertained. Endometriosis was associated with an increased overall risk of skin cancer (HR=1.28, 95% CI=1.05–1.55). When considering skin cancer type, endometriosis was associated with melanoma risk (HR=1.64, 95% CI=1.15–2.35), but not with SCC (HR=1.21, 95% CI=0.62–2.36) or BCC (HR=1.16, 95% CI=0.91–1.48) (non-melanoma skin cancers combined: HR=1.17, 95% CI=0.93–1.46), although no heterogeneity was detected across skin cancer types (Phomogeneity=0.13). Conclusion These data support an association between a personal history of endometriosis and the risk of skin cancer and suggest that the association is strongest for melanoma.

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“…Interestingly, cross-sectional studies have suggested that the proportion of naturally red haired women is greater among women with endometriosis compared to the general population (Frish et al, 1992;Woodworth et al, 1995;Wyshak and Frish, 2000). A recent large cohort study has confirmed this finding (Missmer et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D reserve is higher in women with endometriosis

et al. 2007

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BACKGROUND: An immune-mediated defect in recognition and elimination of endometrial fragments refluxed in the peritoneal cavity has been hypothesized to play a crucial role in endometriosis development. Since vitamin D is an effective modulator of the immune system, we have hypothesized that the vitamin D status may have a role in the pathogenesis of endometriosis. METHODS: Women of reproductive age selected for surgery for gynecological indications were enrolled in this prospective cohort study. Serum levels of 25-hydroxyvitamin-D 3 , 1,25-dihydroxyvitamin-D 3 and Ca 21 were assessed. RESULTS: Eighty-seven women with endometriosis and 53 controls were recruited. Mean (+ + + + + SD) levels of 25-hydroxyvitamin-D 3 in women with and without endometriosis were 24.9 + + + + + 14.8 ng/ml and 20.4 + + + + + 11.8, respectively (P 5 0.05). The Odds Ratio (95% Confidence Interval) for endometriosis in patients with levels exceeding the 75th percentile of the serum distribution of the molecule (28.2 ng/ml) was 4.8 (1.7-13.5). A positive gradient according to the severity of the disease was also documented. A trend towards higher levels of 1,25-dihydroxyvitamin-D 3 and Ca 21 was observed in women with endometriosis, but differences did not reach statistical significance. As expected, serum concentrations of 25-hydroxyvitamin-D 3 and 1,25-dihydroxyvitamin-D 3, but not Ca 21 , are influenced by the season (P < 0.001, P 5 0.004, P 5 0.57, respectively), while levels of the three molecules did not vary according to the phase of the menstrual cycle. CONCLUSIONS: Endometriosis is associated with higher serum levels of vitamin D.

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A prospective study on the association between red hair color and endometriosis in infertile patients

Cited by 45 publications

References 5 publications

Personal History of Endometriosis and Risk of Cutaneous Melanoma in a Large Prospective Cohort of French Women

Personal History of Endometriosis and Risk of Cutaneous Melanoma in a Large Prospective Cohort of French Women

Endometriosis and the risk of skin cancer: a prospective cohort study

Vitamin D reserve is higher in women with endometriosis

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