Personal History of Endometriosis and Risk of Cutaneous Melanoma in a Large Prospective Cohort of French Women

Kvaskoff, Marina; Mesrine, Sylvie; Fournier, Agnès; Boutron‐Ruault, Marie‐Christine; Clavel‐Chapelon, Françoise

doi:10.1001/archinte.167.19.2061

Cited by 36 publications

(19 citation statements)

References 25 publications

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“…Our findings confirm a positive association between endometriosis and melanoma that was reported in previous studies (4, 11, 12, 16, 32–34), including in E3N (4), in which we reported a 62% higher risk of melanoma among women with endometriosis with a 12-year follow-up. The present study expands upon this previous work with an additional nine years of follow-up.…”

Section: Discussionsupporting

confidence: 92%

“…To our knowledge, this is the largest and most complete analysis of endometriosis and skin cancer heterogeneity to date. This study extends our previous work on endometriosis in relation to melanoma (4) by i) additionally investigating NMSC risk and allowing comparisons between risks of NMSCs and melanoma, ii) investigating the association with melanoma with nine years of additional follow-up and accrual of melanoma cases, thereby allowing assessment of heterogeneity across melanoma subgroups, and iii) investigating potential mediators of these associations, which has never been addressed.…”

Section: Introductionmentioning

confidence: 66%

“…A common genetic basis for the two diseases has previously been suggested (4). Endometriosis risk has been associated with melanoma risk factors known to be of genetic origin: red hair (11, 13, 38, 39), freckling (27, 40), number of naevi (13, 14, 26, 27), skin sensitivity to sun exposure (26, 27, 40, 41), and eye colour (40, 42).…”

Section: Discussionmentioning

confidence: 96%

“…Women with endometriosis have been reported to be at higher risk for various chronic diseases, including several malignancies such as ovarian cancer, breast cancer, and melanoma skin cancer (4–6). …”

Section: Introductionmentioning

confidence: 99%

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Endometriosis and the risk of skin cancer: a prospective cohort study

Farland

Lorrain

Missmer

et al. 2017

Cancer Causes Control

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Purpose Endometriosis has been associated with an increased risk of skin melanoma. However, associations with other skin cancer types and how they compare with melanoma are unclear. Our objective was to prospectively investigate the relationships between endometriosis and risk of non-melanoma and melanoma skin cancers. Methods E3N is a prospective cohort of 98,995 French women aged 40–65 years in 1990. Data on surgically-confirmed endometriosis and skin cancer diagnoses were collected every 2–3 years through self-report, with skin cancer cases confirmed through pathology reports. Hazard Ratios (HR) and 95% confidence intervals (CIs) were calculated using Cox regression models. Results Between 1990 and 2008, 535 melanoma, 247 squamous-cell carcinoma (SCC), and 1,712 basal-cell carcinoma (BCC) cases were ascertained. Endometriosis was associated with an increased overall risk of skin cancer (HR=1.28, 95% CI=1.05–1.55). When considering skin cancer type, endometriosis was associated with melanoma risk (HR=1.64, 95% CI=1.15–2.35), but not with SCC (HR=1.21, 95% CI=0.62–2.36) or BCC (HR=1.16, 95% CI=0.91–1.48) (non-melanoma skin cancers combined: HR=1.17, 95% CI=0.93–1.46), although no heterogeneity was detected across skin cancer types (Phomogeneity=0.13). Conclusion These data support an association between a personal history of endometriosis and the risk of skin cancer and suggest that the association is strongest for melanoma.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Endometriosis and the risk of skin cancer: a prospective cohort study

Farland

Lorrain

Missmer

et al. 2017

Cancer Causes Control

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“…Further, dioxin and endocrine-disrupting environmental toxicants that modify the inflammatory process have been strongly associated with endometriosis (9). Other investigators have reported that women with endometriosis are at increased risk of melanoma (10, 11) and non-Hodgkin’s lymphoma (5, 12). The relationship between endometriosis and breast cancer is less certain (4, 10, 13, 14).…”

mentioning

confidence: 99%

Cancers, infections, and endocrine diseases in women with endometriosis

Gemmill

Stratton

Cleary

et al. 2010

Fertility and Sterility

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Objective To assess the prevalence of patient-reported, physician-diagnosed comorbid conditions in women with endometriosis. Design Cross-sectional study of self-reported survey data. Setting Academic research. Patient(s) Four thousand three hundred thirty-one Endometriosis Association (EA) members reporting surgically diagnosed endometriosis. Intervention(s) None. Main Outcome Measure(s) Self-reported, physician-diagnosed infectious diseases, cancers, and endocrine diseases. Result(s) Nearly two-thirds of women reported one or more of the assessed conditions. Recurrent upper respiratory infections and recurrent vaginal infections were common and more likely in women responding to the EA survey. Melanoma was reported by 0.7% (n = 29), breast cancer by 0.4% (n = 16), and ovarian cancer by 0.2% (n = 10). While ovarian cancer and melanoma were significantly more common than in the general population, breast cancer was surprisingly less common. Addison’s disease and Cushing’s syndrome were rare (0.2% and 0.1%, respectively). Conclusion(s) Respondents reported a higher prevalence of recurrent upper respiratory or vaginal infections, melanoma, and ovarian cancer than the general population. These findings document other potential associations related to the immune system, which may help focus future research into this disease.

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Molecular Genetics of Endometriosis

Painter

Zondervan

Missmer

et al. 2011

Encyclopedia of Life Sciences

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Endometriosis is a gynaecological disease that affects 6–10% of women of reproductive age. Symptoms vary but commonly include severe menstrual and pelvic pain and infertility, all of which can have major impacts on the lives of affected women. Linkage studies have identified several chromosomal regions but the genes contributing to these linkage signals have yet to be identified. Candidate gene studies on over 80 genes have not shown robust evidence of association, mostly due to the limited power to detect individual risk variants of small effects. Four groups have now conducted genome‐wide association studies for endometriosis, revealing a number of intriguing candidates that may contribute to disease risk. Further research aimed at increasing our understanding of the genes and biological pathways underlying endometriosis may provide better and more targeted diagnosis and treatment options in the future. Key Concepts: Endometriosis is a gynaecological disease that occurs when tissue resembling endometrium (the tissue that lines the inside of the uterus) attaches and grows on organs in the body cavity, including the ovaries, fallopian tubes, intestine and bowel. Endometriosis affects 6–10% of women during their reproductive years and the symptoms, including severe menstrual and pelvic pain and sub‐ or infertility, can greatly impact an affected woman's physical and psychological wellbeing as well as her family and working life. The financial cost of endometriosis is amongst the highest of all complex diseases, with direct (medical and surgical treatment) and indirect (loss of income, reduced productivity, infertility treatment and social withdrawal) health care costs estimated at >$15 billion annually in the US alone. Linkage studies on large numbers of families have indicated chromosomal regions that may harbour endometriosis susceptibility genes but these are yet to be definitively identified. Candidate gene association studies on over 80 genes have not produced convincing evidence of gene robustly associated with endometriosis susceptibility. Genome‐wide association studies have identified a small number of chromosomal areas that harbour extremely interesting candidate genes that should be followed up in the future. Understanding the genes and biological pathways underlying susceptibility to endometriosis may eventually lead to better diagnostic and treatment options for women affected by this common and often debilitating disease.

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Personal History of Endometriosis and Risk of Cutaneous Melanoma in a Large Prospective Cohort of French Women

Cited by 36 publications

References 25 publications

Endometriosis and the risk of skin cancer: a prospective cohort study

Endometriosis and the risk of skin cancer: a prospective cohort study

Cancers, infections, and endocrine diseases in women with endometriosis

Molecular Genetics of Endometriosis

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