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Higher intakes of Ca, P, vitamin B12, proteins, and unsaturated fats and moderate alcohol, provided by dietary patterns rich in cheese, milk, and charcuteries, were related to a lower risk of wrist and hip fractures in our cohort.

Background: Dietary and nutrient patterns have been linked to health outcomes related to aging. Food intake is influenced by environmental and genetic factors. The aim of the present study was to compare nutrient patterns across two elderly populations sharing a common ancestral cultural background, but living in different environments. Methods: The diet quality, lifestyle and socioeconomic characteristics of participants from the Three-City Study (3C, France, n = 1712) and the Québec Longitudinal Study on Nutrition and Successful Aging (NuAge, Quebec, Canada, n = 1596) were analyzed. Nutrient patterns and their food sources were identified in the two samples using principal component analysis. Diet quality was compared across sample-specific patterns by describing weekly food intake and associations with the Canadian Healthy Eating Index (C-HEI). Results: Three nutrient patterns were retained in each study: a healthy, a Western and a more traditional pattern. These patterns accounted for 50.1% and 53.5% of the total variance in 3C and NuAge, respectively. Higher education and non-physical occupations over lifetime were associated with healthy patterns in both studies. Other characteristics such as living alone, having a body mass index lower than 25 and being an ex-smoker were associated with the healthy pattern in NuAge. No association between these characteristics and the nutrient patterns was noted in 3C. The healthy and Western patterns from each sample also showed an inverse association with C-HEI. Conclusion: The two healthy patterns showed important similarities: adequate food variety, consumption of healthy foods and associations with common sociodemographic factors. This work highlights that nutrient patterns derived using a posteriori methods may be useful to compare the nutritional quality of the diet of distinct populations.

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( P < 0.0001), alcohol intake ( P = 0.0006), and female gender ( P = 0.02), and decreased with intensive consumption of n-6 oils ( P = 0.02). The positive association between fi sh consumption and plasma DHA was highly signifi cant whatever the APOE genotype ( P < 0.0001) but stronger in APOE4 noncarriers than in carriers ( P = 0.06 for interaction). Plasma DHA increased signifi cantly with age ( P = 0.009) in APOE4 noncarriers only. These fi ndings suggest that dietary habits, gender, and APOE4 genotype should be considered when designing interventions to increase n-3 PUFA blood levels in older people. -Samieri, C., S. Lorrain, B. Buaud, C. Vaysse, C. Berr, E. Peuchant, S. C. Cunnane, and P. Barberger-Gateau. Relationship between diet and plasma long-chain n-3 PUFAs in older people: impact of apolipoprotein E genotype. Long-chain n-3 PUFAs [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] could potentially exert a protective effect against brain aging due principally to their vascular, anti-infl ammatory, and neuroprotective properties ( 1 ). Accordingly, several epidemiological studies have observed an inverse association between habitual consumption of long-chain n-3 PUFAs or fi sh, their main dietary source, and risk of cognitive decline or dementia ( 1 ). However, this protective association may be limited to Abbreviations: 3C, Three-City; AD, Alzheimer's disease; ALA, ␣ -linolenic acid; APOE4 , 4 allele of the APOE gene; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; FFQ, food frequency questionnaire; HR, hazard ratio; RCT, randomized controlled trial.

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ObjectivesThe primary objective of this study is to determine the current level of patient medication exposure in Level 3 Neonatal Wards (L3NW). The secondary objective is to evaluate in the first month of life the rate of medication prescription not cited in the Summary of Product Characteristics (SmPC). A database containing all the medication prescriptions is collected as part of a prescription benchmarking program in the L3NW.Material and methodsThe research is a two-year observational cohort study (2017–2018) with retrospective analysis of medications prescribed in 29 French L3NW. Seventeen L3NW are present since the beginning of the study and 12 have been progressively included. All neonatal units used the same computerized system of prescription, and all prescription data were completely de-identified within each hospital before being stored in a common data warehouse.ResultsThe study population includes 27,382 newborns. Two hundred and sixty-one different medications (International Nonproprietary Names, INN) were prescribed. Twelve INN (including paracetamol) were prescribed for at least 10% of patients, 55 for less than 10% but at least 1% and 194 to less than 1%. The lowest gestational ages (GA) were exposed to the greatest number of medications (18.0 below 28 weeks of gestation (WG) to 4.1 above 36 WG) (p<0.0001). In addition, 69.2% of the 351 different combinations of an medication INN and a route of administration have no indication for the first month of life according to the French SmPC. Ninety-five percent of premature infants with GA less than 32 weeks received at least one medication not cited in SmPC.ConclusionNeonates remain therapeutic orphans. The consequences of polypharmacy in L3NW should be quickly assessed, especially in the most immature infants.

Purpose Endometriosis has been associated with an increased risk of skin melanoma. However, associations with other skin cancer types and how they compare with melanoma are unclear. Our objective was to prospectively investigate the relationships between endometriosis and risk of non-melanoma and melanoma skin cancers. Methods E3N is a prospective cohort of 98,995 French women aged 40–65 years in 1990. Data on surgically-confirmed endometriosis and skin cancer diagnoses were collected every 2–3 years through self-report, with skin cancer cases confirmed through pathology reports. Hazard Ratios (HR) and 95% confidence intervals (CIs) were calculated using Cox regression models. Results Between 1990 and 2008, 535 melanoma, 247 squamous-cell carcinoma (SCC), and 1,712 basal-cell carcinoma (BCC) cases were ascertained. Endometriosis was associated with an increased overall risk of skin cancer (HR=1.28, 95% CI=1.05–1.55). When considering skin cancer type, endometriosis was associated with melanoma risk (HR=1.64, 95% CI=1.15–2.35), but not with SCC (HR=1.21, 95% CI=0.62–2.36) or BCC (HR=1.16, 95% CI=0.91–1.48) (non-melanoma skin cancers combined: HR=1.17, 95% CI=0.93–1.46), although no heterogeneity was detected across skin cancer types (Phomogeneity=0.13). Conclusion These data support an association between a personal history of endometriosis and the risk of skin cancer and suggest that the association is strongest for melanoma.