A potential mediator for photodynamic therapy based on silver nanoparticles functionalized with porphyrin

Mahajan, Prasad G.; Dige, Nilam C.; Vanjare, Balasaheb D.; Eo, Seong‐Hui; Seo, Sung‐Yum; Kim, Song Ja; Hong, Seong-Karp; Choi, Chang‐Shik; Lee, Ki Hwan

doi:10.1016/j.jphotochem.2019.03.034

Cited by 26 publications

(16 citation statements)

References 42 publications

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“…Although we exceeded that concentration by a 10-fold, no cytotoxic effect was observed on normal keratinocytes. A similar result was obtained for A375, which is consistent with the results of other studies where AgNPs were used [62]. As the findings of others suggested that large nanoparticles have no cytotoxic effect on cells [63], this lack of toxicity in our study could be explained by the NPs' size rather than the surface coating or the plant extract used.…”

Section: Mtt Assaysupporting

confidence: 93%

“…Although we exceeded that concentration by a 10-fold, no cytotoxic effect was observed on normal keratinocytes. A similar result was obtained for A375, which is consistent with the results of other studies where AgNPs were used [62]. As the findings of others Berberine from C. majus extract presents a strong band of aromatic vibrations at 1609 cm-1 , the CH wag vibrations around 1385 cm −1 , the ring deformation band at 1080 cm −1 , and the OCO stretching of dioxolan ring at 1040 cm −1 as a shoulder ( Figure 5B) [59].…”

Section: Mtt Assaysupporting

confidence: 91%

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Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

et al. 2020

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Medicinal plants are often used as reducing agents to prepare metal nanoparticles through green-synthesis due to natural compounds and their potential as chemotherapeutic drugs. Thus, three types of eco-friendly Ag-MnO2 nanoparticles (Ag-MnO2NPs) were synthesized using C. majus (CmNPs), V. minor (VmNPs), and a 1:1 mixture of the two extracts (MNPs). These NPs were characterized using S/TEM, EDX, XRD, and FTIR methods, and their biological activity was assessed in vitro on normal keratinocytes (HaCaT) and skin melanoma cells (A375). All synthesized NPs had manganese oxide in the middle, and silver oxide and plant extract on the exterior. The NPs had different forms (polygonal, oval, and spherical), uniformly distributed, with crystalline structures and different sizes (9.3 nm for MNPs; 10 nm for VmNPs, and 32.4 nm for CmNPs). The best results were obtained with VmNPs, which reduced the viability of A375 cells up 38.8% and had a moderate cytotoxic effect on HaCaT (46.4%) at concentrations above 500 µg/mL. At the same concentrations, CmNPs had a rather proliferative effect, whereas MNPs negatively affected both cell lines. For the first time, this paper proved the synergistic action of the combined C. majus and V. minor extracts to form small and uniformly distributed Ag-MnO2NPs with high potential for selective treatments.

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Section: Mtt Assaysupporting

confidence: 93%

“…Although we exceeded that concentration by a 10-fold, no cytotoxic effect was observed on normal keratinocytes. A similar result was obtained for A375, which is consistent with the results of other studies where AgNPs were used [62]. As the findings of others Berberine from C. majus extract presents a strong band of aromatic vibrations at 1609 cm-1 , the CH wag vibrations around 1385 cm −1 , the ring deformation band at 1080 cm −1 , and the OCO stretching of dioxolan ring at 1040 cm −1 as a shoulder ( Figure 5B) [59].…”

Section: Mtt Assaysupporting

confidence: 91%

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

et al. 2020

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“…Synergistic effects were reported following the combined treatment, such as severe mitochondrial damage and ROS generation [295]. Enhanced cytotoxic effects were also reported in the case of melanoma cells, where AgNPs functionalized with porphyrin acted as mediators for enhanced PDT [296].…”

Section: Silver Nanoparticles For Cancer Therapymentioning

confidence: 99%

An Updated Review on Silver Nanoparticles in Biomedicine

et al. 2020

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Silver nanoparticles (AgNPs) represent one of the most explored categories of nanomaterials for new and improved biomaterials and biotechnologies, with impressive use in the pharmaceutical and cosmetic industry, anti-infective therapy and wound care, food and the textile industry. Their extensive and versatile applicability relies on the genuine and easy-tunable properties of nanosilver, including remarkable physicochemical behavior, exceptional antimicrobial efficiency, anti-inflammatory action and antitumor activity. Besides commercially available and clinically safe AgNPs-based products, a substantial number of recent studies assessed the applicability of nanosilver as therapeutic agents in augmented and alternative strategies for cancer therapy, sensing and diagnosis platforms, restorative and regenerative biomaterials. Given the beneficial interactions of AgNPs with living structures and their nontoxic effects on healthy human cells, they represent an accurate candidate for various biomedical products. In the present review, the most important and recent applications of AgNPs in biomedical products and biomedicine are considered.

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“…This indicates that different types of cancer cells respond differently to the same NPs, and thus, studies on various cancer cell types need to be examined. Mahajan et al (2019) synthesized porphyrin-loaded mercaptosuccinic acid capped silver nanoparticles for PDT and cell imaging applications. The average size distribution of synthesized nanoparticles shows 110 nm with excellent zeta potential (−31.1 mV), and the scanning electron microscopy study shows the uneven cube synthesized nanoparticles were studied against A375 malignant melanoma cancer cells.…”

Section: Silver Nanoparticlesmentioning

confidence: 99%

Biocompatible Nanocarriers for Enhanced Cancer Photodynamic Therapy Applications

Kumar

Abrahamse

2021

Pharmaceutics

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In recent years, the role of nanotechnology in drug delivery has become increasingly important, and this field of research holds many potential benefits for cancer treatment, particularly, in achieving cancer cell targeting and reducing the side effects of anticancer drugs. Biocompatible and biodegradable properties have been essential for using a novel material as a carrier molecule in drug delivery applications. Biocompatible nanocarriers are easy to synthesize, and their surface chemistry often enables them to load different types of photosensitizers (PS) to use targeted photodynamic therapy (PDT) for cancer treatment. This review article explores recent studies on the use of different biocompatible nanocarriers, their potential applications in PDT, including PS-loaded biocompatible nanocarriers, and the effective targeting therapy of PS-loaded biocompatible nanocarriers in PDT for cancer treatment. Furthermore, the review briefly recaps the global clinical trials of PDT and its applications in cancer treatment.

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A potential mediator for photodynamic therapy based on silver nanoparticles functionalized with porphyrin

Cited by 26 publications

References 42 publications

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

An Updated Review on Silver Nanoparticles in Biomedicine

Biocompatible Nanocarriers for Enhanced Cancer Photodynamic Therapy Applications

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