A Possible Role of Helicobacter pylori in Chronic Rhinosinusitis: A Preliminary Report

Abstract

It is possible to detect H pylori in the sinus mucosa of some patients with CRS. However, whether H pylori is a causative agent for CRS or a result of CRS is not known.

Detection of Helicobacter pylori in Nasal Polyps

“…Some but not all studies have shown the association between H. pylori and nasal polyps, but none has established causation yet. Ozdek et al [13] and Nikakhlagh et al [15] found H. pylori DNA in patients with chronic rhinosinusitis using PCR assay. Studies by Vceva et al [23] and Noorbakhsh et al [32] used both PCR and serology and concluded a possible role of H. pylori in emergence of nasal polyps.…”

“…It has also been identified in human dental plaques, saliva, in oral lesions and ulcers, and in adenotonsillar tissue [10,11]. Later studies have detected H. pylori in nasal mucosa of chronic rhinosinusitis [12][13][14][15] and nasal polyps [16][17][18][19][20][21][22][23][24] with variable results, which can be attributed to different sample size and detecting methods.…”

Association of cagA+ Helicobacter pylori with Adenotonsillar Hypertrophy

“…Despite some published reports on epidemiology of the bacterium (Li et al 1995;MravakStipetic et al 1998;di Banaventura et al 2001;Cirak et al 2003;Morinaka et al 2003), mode of transmission and role of H. pylori detected from tonsil and adenoid tissues on its epidemiology have not been completely understood. There are contradictory data on the presence of H. pylori in these tissues.…”

“…In addition to gastric specimens, detection of H. pylori from different regions such as oral region suggests that the bacterium may lead to a broad spectrum of clinical manifestations (Li et al 1995;Cammarota et al 1996;Mravak-Stipetic et al 1998;Jun et al 2005). The presence of H. pylori in oral samples may be a cause of the high incidence of H. pylori infection in the world (Unver et al 2001;Ozdek et al 2003;Morinaka et al 2003).…”

“…However, to the best of our knowledge, there is only one study about cagA + in tonsil and adenoid tissues. Cirak et al (2003) reported that presence rate of cagA in H. pylori-positive tonsil and adenoid tissues was 71%.…”