Association of cagA+ Helicobacter pylori with Adenotonsillar Hypertrophy

Bulut, Yasemin; Agacayak, Ahmet; Karlıdağ, Turgut; Toraman, Zülal Aşçı; Yılmaz, Mustafa

doi:10.1620/tjem.209.229

Cited by 38 publications

(39 citation statements)

References 19 publications

(28 reference statements)

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“…Unver et al [7] in adenoid tissue and Khademi et al [17] in tonsillar and adenoid tissue investigated HP by the Campylobacter-like organism (CLO) test and found positive results. Cirak et al [18] and Bulut et al [19] investigated HP in tonsillar and adenoid tissue by PCR and reported positive results. Bitar et al [20] found positivity by RUT and histology, but no positivity by nested PCR in adenoid tissue.…”

Section: Discussionmentioning

confidence: 99%

Does Helicobacter Pylori Have a Role in the Etiology of Adenoid Hypertrophy?

Aydın

Aydoğan

Taştan

et al. 2011

Indian J Otolaryngol Head Neck Surg

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To investigate whether there is any association between nasopharyngeal reflux and adenoid hypertrophy in children by using 24-h pH monitoring with dual probe and to determine whether Helicobacter pylori simply colonises in adenoid tissue or it is present there temporarily due to extraesophageal reflux. A prospective study at a tertiary referral center. Thirty-two patients who underwent adenoidectomy, aged ranged between 4 and 13 were included. All children with adenoid hypertrophy underwent 24-h pH monitoring with a dual probe. Proximal probe was placed in the nasopharynx. The presence of nasopharyngeal reflux and gastroesophageal reflux were investigated by 24-h pH monitoring. The presence of H. pylori was investigated in adenoidectomy samples by HP-fast test. Of the 32 patients who underwent adenoidectomy, 5 had nasopharyngeal reflux positivity while 27 patients did not show nasopharyngeal reflux positivity with pH monitorisation. Helicobacter pylori could not be detected in 5 nasopharyngeal reflux positive children while 3 of 27 nasopharyngeal reflux negative children showed H. pylori positivity, one of them in the mucosa and others in the core. This study demonstrated the high incidence of nasopharyngeal reflux and gastroesophageal reflux in adenoid hypertrophy and the possible colonisation of H. pylori in the adenoid tissue. This may change the assesment of children with adenotonsillar hypertrophy in near future. However, more placebo controlled and double blind studies and larger series are still needed to support this hypothesis.

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Section: Discussionmentioning

confidence: 99%

Does Helicobacter Pylori Have a Role in the Etiology of Adenoid Hypertrophy?

Aydın

Aydoğan

Taştan

et al. 2011

Indian J Otolaryngol Head Neck Surg

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“…Minocha found a decreased prevalence of H. pylori gastric colonization in subjects with a history of tonsillectomy [14] but Di Bonaventura et al did not support this argument [14]. Bulut et al studied association of cytotoxin-associated gene A (cag A) of H. pylori with adeno-tonsillar hypertrophy and suggested that presence of cag A + H. pylori may be associated with development of tonsillar hypertrophy [15]. Khademi et al compared helicobacter colonization on the tonsillar surface versus tonsillar core by RUT test, and (83%) positive findings core tissue RUT and suggested a tonsillar surface SWAB do not reliably reflect the presence or absence of H. pylori colonization [11].…”

Section: Discussionmentioning

confidence: 99%

Comparative assessment of Helicobacter pylori colonization in children tonsillar tissues

Moghaddam

Rafeey

Radfar

2009

International Journal of Pediatric Otorhinolaryngology

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“…These two reasons per se are sufficient to predispose, trigger and maintain the course of idiopathic skin conditions. In addition, different reports in literature have confirmed the association of cytotoxin-associated gene A (cagA) positive H. pylori strains, and emphasized that cagA of H. pylori encodes a highly immunogenic and virulence-associated protein; the presence of this virulent gene in the body could affect the clinical outcome in many patients [13]. Therefore, the literature correlates between existence of H. pylori and many pathologic skin disorders [7].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effect of Combined Colon Clear and Cupping Therapy on Idiopathic Skin Pathology

Nasrat¹,

Nasrat²,

Nasrat³

et al. 2015

Gen Med (Los Angel)

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The study aimed at demonstration of idiopathic skin pathology; influence of Helicobacter pylori and therapeutic effect of combined colon clear with cupping therapy.The complex spectrum of inflammatory skin diseases is ever expanding and evolving particularly in psoriasis, idiopathic eczema and atopic dermatitis. The etiology of these inflammatory atopic dermato-pathological disorders is still obscure but it is basically autoimmune triggered and maintained by an aberrant response of the skin immune system cells. Pro-inflammatory cytokines play a pivot role in the pathogenesis of immune skin pathologies. H. pylori could migrate or get forced to migrate to the colon leading to accumulation of profuse toxic amounts of ammonia unopposed or buffered by any acidity. The association of H. pylori with autoimmune disorders and chronic idiopathic dermatitis was sufficiently reported. The role played by the increased mucosal production of inflammatory mediators (cytokines) induced by H. pylori was also clearly illustrated. Antibiotics are seldom effective against extra-gastric H. pylori strains. A potent natural purgative is the only measure to eradicate H. pylori strains migrated to the colon. Elimination of toxic metabolites and inflammatory mediators from the body is a challenge which is only feasible via seroclearance blood-let out cupping therapy.Seven patients with atopic dermatitis, seven with idiopathic eczema and seven with psoriasis were randomly included in the study on the basis of being newly discovered, not starting any definitive treatment and having a frank history of H. pylori dyspepsia which was proved by sensitive specific tests. All patients underwent colon clear employing the potent natural senna purge which was followed in five days by a session of blood-let out seroclearance cupping therapy on the upper back.Marked improvement as regards the scales, itchiness and discoloration was seen in 5 patients with dermatitis, 6 patients with eczema and 4 patients with psoriasis after colon clear. Improvement was much more marked after cupping therapy.On conclusion, combined natural colon clear and blood-let out cupping therapy should be considered as a potent adjuvant therapeutic measure in idiopathic immune skin disorders associated with H. pylori.

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Association of cagA+ Helicobacter pylori with Adenotonsillar Hypertrophy

Cited by 38 publications

References 19 publications

Does Helicobacter Pylori Have a Role in the Etiology of Adenoid Hypertrophy?

Does Helicobacter Pylori Have a Role in the Etiology of Adenoid Hypertrophy?

Comparative assessment of Helicobacter pylori colonization in children tonsillar tissues

Therapeutic Effect of Combined Colon Clear and Cupping Therapy on Idiopathic Skin Pathology

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