Does Helicobacter Pylori Have a Role in the Etiology of Adenoid Hypertrophy?

Aydın, Esra; Aydoğan, Filiz; Taştan, Eren; Arslan, Necmi; Karaca, Gökhan

doi:10.1007/s12070-011-0310-y

Cited by 8 publications

(17 citation statements)

References 21 publications

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“…There was no significant difference in terms of H. pylori colonization between those with GERD history and the ones without it. Similar to our study, the study by Aydin et al (22) proved that the prevalence of H. pylori colonization in adenotonsillar tissue was higher than in cases without GERD than in GERDpositive patients.…”

Section: Discussionsupporting

confidence: 92%

Helicobacter pylori Colonization in Patients with Adenotonsillar Hypertrophy: Study on Prevalence and Clinical Characteristics of Colonized Patients and Possible Association with Complications

Pourmousa

Varshoi

Nikkhah

et al. 2020

Arch Pediatr Infect Dis

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Background: Adenotonsillar hypertrophy (ATH) is a common problem in children that causes the obstruction of airways and other relevant complications. Helicobacter pylori (H. pylori) is considered one of the microbial causes of ATH development. Objectives: The study aimed to determine the H. pylori colonization in patients with adenotonsillar hypertrophy and assess the prevalence and clinical characteristics of colonized patients and possible association with complications. Methods: This study was carried out on 114 children with ATH referring to the Bouali Hospital of Sari from December 2017 to December 2018. Adenotonsillar samples were prepared from the right and left tonsils and adenoid of each patient. The Rapid Urease test (RUT) and nested-PCR were performed on the samples. Data analysis was performed with SPSS version 20 software. Results:The participants included 52 females and 62 males with a mean age of 7.19 ± 3.08 years. The RUT was positive for 59 participants: 26 in right tonsil, 31 in left tonsil, and two in adenoid samples. Helicobacter pylori was detected in the adenotonsillar tissue of 95 patients using nested-PCR. No significant association was found between the PCR results and gender (P = 0.123). Conclusions: This study approved the presence of H. pylori in the adenotonsillar tissue of children with ATH and highlighted the concept that the pharynx could be an extra gastric reservoir of H. pylori. However, we failed to prove an association between H. pylori adenotonsillar colonization with ATH and acute otitis media.

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Section: Discussionsupporting

confidence: 92%

Helicobacter pylori Colonization in Patients with Adenotonsillar Hypertrophy: Study on Prevalence and Clinical Characteristics of Colonized Patients and Possible Association with Complications

Pourmousa

Varshoi

Nikkhah

et al. 2020

Arch Pediatr Infect Dis

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“…After discussion between reviewers, 26 papers were included for full-text review. 23-48 Twelve papers were subsequently excluded, yielding 14 that were identified for data collection and qualitative analysis. 23-34 Further details of the excluded papers may be found in Appendix A (available in the online version of the article).…”

Section: Resultsmentioning

confidence: 99%

“…A total of 1082 studies were identified through our literature search and reviewed ( Figure 1). After discussion between reviewers, 26 papers were included for full‐text review 23‐48 . Twelve papers were subsequently excluded, yielding 14 that were identified for data collection and qualitative analysis 23‐34 .…”

Section: Resultsmentioning

confidence: 99%

“…Twelve papers were subsequently excluded, yielding 14 that were identified for data collection and qualitative analysis. [23][24][25][26][27][28][29][30][31][32][33][34] Further details of the excluded papers may be found in Appendix A (available in the online version of the article). The details of the papers included in the analysis are located in Table 1.…”

Section: General Study Informationmentioning

confidence: 99%

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The Role of Helicobacter pylori in Laryngopharyngeal Reflux: A Systematic Review and Meta‐analysis

Campbell

Kilty

Hutton

et al. 2016

Otolaryngol.--head neck surg.

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Objective The primary objective was to determine the prevalence of Helicobacter pylori among patients with laryngopharyngeal reflux. The secondary objective was determining if H pylori eradication leads to greater symptom improvement in patients with laryngopharyngeal reflux as compared with standard proton pump inhibitor therapy alone. Data Sources EMBASE, Cumulative Index to Nursing and Allied Health Literature, MEDLINE, World Health Organization International Clinical Trials Registry Platform, European Union Clinical Trials Register, Cochrane Library databases of clinical trials, and ClinicalTrials.gov. Review Methods A systematic review was performed of studies assessing the diagnosis or treatment of H pylori among patients with laryngopharyngeal reflux. Randomized controlled trials, cohort studies, case-control studies, and case series were included. A meta-analysis of prevalence data and assessment of heterogeneity was performed on relevant studies. Results Fourteen studies were analyzed in the review, with 13 eligible for the meta-analysis. We determined that the prevalence of H pylori among patients with laryngopharyngeal reflux was 43.9% (95% confidence interval, 32.1-56.5). The heterogeneity of studies was high, with an overall I value of 92.3%. We were unable to quantitatively assess findings for our secondary outcome, since H pylori identification and treatment were not the primary focus of the majority of studies. Conclusion There is a high rate of H pylori infection among patients with laryngopharyngeal reflux. The infection rate in North America and Western Europe has not been adequately studied. There is insufficient evidence to make a recommendation regarding the testing and treatment of H pylori infection among patients with laryngopharyngeal reflux.

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“…1 The disorder affects the upper respiratory tract. 2 The tonsils are lymphoepithelial tissues located at the entrance of the upper aerodigestive tract. 4 They consist of the nasopharyngeal (adenoid), palatine, lingual, posterior and lateral pharyngeal wall parts.…”

Section: Introductionmentioning

confidence: 99%

Current trends of adenotonsillar hypertrophy presentation in a developing country, Nigeria

Adegbiji

Aremu

Nwawolo

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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Background: Adenotonsillar hypertrophy is a common paediatric disorder in Otorhinolaryngological practice worldwide. The prevalence, clinical manifestations and predisposing factors are well documented in developed countries. However, available data shows differences between the various studies. There is paucity of data from developing countries. Thus, this study is aimed at assessing the age group distribution, predisposing factors, clinical manifestation and complications of adenotonsillar hypertrophy in a developing country. Methods: It is a prospective study of children under 10 years over a period of 24 months. Interviewer assisted questionnaire was administered. Data obtained were statistically analysed using SPSS version 18. Results: Two hundred and fifty three, 253 subjects were enrolled into the study. Adenotonsillar hypertrophy affected all age groups studied. A high incidence was noted among the under 2 year olds. The Male: Female ratio was 2:1. Chronic cases constituted 55.7% of our study population. Common predisposing factors were atopy (73.9%), familial history (67.3%) and recurrent upper respiratory tract infection (58.2%). The Commonest clinical features were snoring, noisy breathing, tonsillar enlargement and narrowing of postnasal space air column. Failure to thrive, otitis media and rhinosinusitis were the commonly associated complications observed. No death was recorded. Conclusions: Adenotonsillar hypertrophy is common in our environment. It is important for all primary health care physicians, paediatricians and otorhinolaryngologists to have a clear knowledge on this ailment. Prevention or reduction in incidence is possible.

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Does Helicobacter Pylori Have a Role in the Etiology of Adenoid Hypertrophy?

Cited by 8 publications

References 21 publications

Helicobacter pylori Colonization in Patients with Adenotonsillar Hypertrophy: Study on Prevalence and Clinical Characteristics of Colonized Patients and Possible Association with Complications

Helicobacter pylori Colonization in Patients with Adenotonsillar Hypertrophy: Study on Prevalence and Clinical Characteristics of Colonized Patients and Possible Association with Complications

The Role of Helicobacter pylori in Laryngopharyngeal Reflux: A Systematic Review and Meta‐analysis

Current trends of adenotonsillar hypertrophy presentation in a developing country, Nigeria

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