A numbering-up metal microreactor for the high-throughput production of a commercial drug by copper catalysis

Ahn, Gwang‐Noh; Yu, Taejong; Lee, Hyune-Jea; Gyak, Ki Won; Kang, Jiho; You, Donghyun; Kim, Dong‐Pyo

doi:10.1039/c9lc00764d

Cited by 52 publications

(35 citation statements)

References 42 publications

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“…The main body of the reactor was fabricated by CNC machining and the complex baffle disk as shown in Scheme 41 was fabricated by 3D printing. 150 The use of 3D-printed stainless-steel metal microreactors (3D-PMR's), have also been gaining interest with the same research group Kim and co-workers fabricating a circular metal reactor with different cross-sectional geometries with the aim to control ultrafast intramolecular rearrangement reactions in a comparative manner. The 3D-PMR with circular channel flow paths demonstrates the improved controllability in rapid Fries-type rearrangement reactions.…”

Section: Reaction Chemistry and Engineering Reviewmentioning

confidence: 99%

Application of reactor engineering concepts in continuous flow chemistry: a review

Neyt

Riley

2021

React. Chem. Eng.

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Section: Reaction Chemistry and Engineering Reviewmentioning

confidence: 99%

Application of reactor engineering concepts in continuous flow chemistry: a review

Neyt

Riley

2021

React. Chem. Eng.

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“…A nonuniform flow distribution can cause a plethora of problems, such under- and overirradiation and a lower conversion. The maldistribution index (MI) is a common method to assess the flow distribution in internally scaled-up reactors [ 9 , 77 – 80 ]. It is defined as the relative standard deviation of the mass flow rate inside the microreactors or channels.…”

Section: Reviewmentioning

confidence: 99%

Dawn of a new era in industrial photochemistry: the scale-up of micro- and mesostructured photoreactors

Kayahan

Jacobs

Braeken³

et al. 2020

Beilstein J. Org. Chem.

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Photochemical activation routes are gaining the attention of the scientific community since they can offer an alternative to the traditional chemical industry that mainly utilizes thermochemical activation of molecules. Photoreactions are fast and selective, which would potentially reduce the downstream costs significantly if the process is optimized properly. With the transition towards green chemistry, the traditional batch photoreactor operation is becoming abundant in this field. Process intensification efforts led to micro- and mesostructured flow photoreactors. In this work, we are reviewing structured photoreactors by elaborating on the bottleneck of this field: the development of an efficient scale-up strategy. In line with this, micro- and mesostructured bench-scale photoreactors were evaluated based on a new benchmark called photochemical space time yield (mol·day−1·kW−1), which takes into account the energy efficiency of the photoreactors. It was manifested that along with the selection of the photoreactor dimensions and an appropriate light source, optimization of the process conditions, such as the residence time and the concentration of the photoactive molecule is also crucial for an efficient photoreactor operation. In this paper, we are aiming to give a comprehensive understanding for scale-up strategies by benchmarking selected photoreactors and by discussing transport phenomena in several other photoreactors.

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“…These advantages stem from the small dimensions (i.e., volumes) of microreactors and lead to more efficient (e.g., higher selectivity and yield [10,[14][15][16]), safer [17] and point-of-use [6] chemical operations. Also, the production therein could be easily regulated by numbering-up [18,19], while preserving the optimized product qualities. Hence, microreactor technology as an innovative technology platform opens a new window to achieve flexible and robust chemical processes that are difficult to perform in traditional reactors.…”

Section: Introductionmentioning

confidence: 99%

Effect of mixing on mass transfer characterization in continuous slugs and dispersed droplets in biphasic slug flow microreactors

Liu

Zhao

Yue

et al. 2021

Chemical Engineering Journal

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Distribution patterns of transferred solute in slugs and droplets were visualized.• Mass transfer in convection-dominated continuous slugs showed nearlyconstant k L a.• k L a in dispersed droplets decreased with τ under significant diffusion.• Distinct correlations were used for mass transfer predictions in slugs and droplets.• Dispersing the resistance phase into continuous slugs benefits system stability.

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A numbering-up metal microreactor for the high-throughput production of a commercial drug by copper catalysis

Abstract: In this study, we present a new numbering-up metal microreactor by integrating a flow distributor and a copper catalytic module for high productivity of a commercial synthetic drug.

Cited by 52 publications

References 42 publications

Application of reactor engineering concepts in continuous flow chemistry: a review

Application of reactor engineering concepts in continuous flow chemistry: a review

Dawn of a new era in industrial photochemistry: the scale-up of micro- and mesostructured photoreactors

Effect of mixing on mass transfer characterization in continuous slugs and dispersed droplets in biphasic slug flow microreactors

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