The adoption of flow technology for the manufacture of chemical entities, and in particular pharmaceuticals, has seen rapid growth over the past two decades with the technology now blurring the...

Highlights  Aluminium was extracted from an ultrafine coal fly ash  Extraction was achieved via thermochemical treatment followed by aqueous leaching  The process used ammonium sulphate, a low-cost, recyclable extracting agent  Extraction efficiencies amounted to 95.

The development of batch–flow hybrid processes is becoming an attractive prospect through which chemists can make use of the best aspects of both technologies.

A concise overview of approaches to perform reductions of various functionalities including aldehydes, ketones, esters, imines, ­nitriles, nitro groups, alkenes and alkynes under continuous-flow conditions are highlighted and discussed in this short review.1 Introduction2 Reduction of Aldehydes, Ketones and Esters3 Reduction of Imines and Nitriles4 Reduction of Nitro Groups5 Reduction of Alkenes6 Partial Reduction of Alkynes7 Conclusion

We report the development of an open-source software approach to monitor and control flow chemistry reactors from any smart device. The dashboard server can be run on a low-cost Raspberry...

Ozonolysis is an attractive, efficient, and green means of introducing oxygen containing functionalities using only oxygen and electricity. Unfortunately, safety issues associated with the accumulation of dissolved ozone and potentially...

We recently reported a novel hybrid batch–flow synthesis of the antipsychotic drug clozapine in which the reduction of a nitroaryl group is described under flow conditions using sodium dithionite. We now report the expansion of this method to include the reduction of aldehydes. The method developed affords yields which are comparable to those under batch conditions, has a reduced reaction time and improved space-time productivity. Furthermore, the approach allows the selective reduction of aldehydes in the presence of ketones and has been demonstrated as a continuous process.

No abstract available.