A novel type of antioxidant isolated from leaf wax of Eucalyptus leaves.

Osawa, Toshihiko; Namiki, Mitsuo

doi:10.1271/bbb1961.45.735

Cited by 291 publications

(196 citation statements)

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“…The antioxidant activity of the water chestnut extract was determined spectrophotometrically according to the thiocyanate method of Osawa and Namiki (1981) with minor modifications. Different concentrations of the extract of water chestnut (Nelumbo nucifera) were mixed with 1 ml of linoleic acid (0.1 g in 100 ml of pure ethanol), 0.2 ml of H 2 O 2 (30 mM), 0.2 ml of ascorbic acid (100 mM), and 0.2 ml of ferric nitrate (20 mM).…”

Section: Lipid Peroxidationmentioning

confidence: 99%

DNA scission inhibition, antioxidant, and antiproliferative activities of water chestnut (Trapa natans) extracted in different solvents

Gani

Rasool

Shah

et al. 2015

CyTA - Journal of Food

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This investigation deals with the study of polyphenolic, antioxidant, and antiproliferative activities of water chestnut extracted in different solvents. The antioxidant activities of the extract in different solvents were the maximum in methanol, followed by ethanol and aqueous solution and were found to be 39.8%, 34.1% and 32.6% from DPPH assay, and 45.64%, 35.08% and 30.52% from lipid peroxidation assay, respectively, whereas the reducing power inhibition assay showed the maximum antioxidant potential in the aqueous extract of the sample, followed by methanolic and ethanolic extracts. The polyphenolic content of the water chestnut was found to be more in methanol than in aqueous and ethanolic extracts. The water chestnut extract also showed the antiproliferative potential when tested against the human colon cancer cell line (Colo-205), human ductal breast epithelial tumor cell line (T47D), and human breast adenocarcinoma cell line (MCF7). It also showed some protection from DNA damage induced by hydroxyl radicals in calf thymus DNA.Keywords: water chestnut; DNA scission inhibition; antioxidant activity; antiproliferative activity Esta investigación trata de un estudio sobre la actividad antioxidante, polifenólica y antiproliferativa de la castaña de agua extraída en diferentes solventes. La actividad antioxidante del extracto en diferentes solventes fue máxima en metanol, seguida por etanol y acuoso, además de encontrarse que era de 39,8%; 34,1% y 32,6%; en el ensayo DPPH y 45%; 64%; 35,08% y 30,52% en el ensayo de peroxidación lipídica respectivamente, mientras que el ensayo de reducción del poder de inhibición mostró el máximo potencial antioxidante en el extracto acuoso de la muestra, seguido por los extractos de metanol y etanol. Se encontró que el contenido polifenólico de la castaña de agua era más presente en metanol que en los extractos acuosos y de etanol. El extracto de castaña de agua también mostró el potencial antiproliferativo cuando se analizadó frente a la línea de la célula humana de cáncer de colon (Colo-205), la línea de la célula humana de tumor ductal epitelial de pecho (T47D) y la línea de la célula humana del adenocarcinoma de pecho (MCF7). También mostró cierta protección del daño del ADN inducido por radicales hidroxilos en ADN de timo de ternera.Palabras clave: castaña de agua; escisión inhibitoria del ADN; actividad antioxidante; actividad antiproliferativa

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Section: Lipid Peroxidationmentioning

confidence: 99%

DNA scission inhibition, antioxidant, and antiproliferative activities of water chestnut (Trapa natans) extracted in different solvents

Gani

Rasool

Shah

et al. 2015

CyTA - Journal of Food

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“…The incubations were carried out in the dark at 40°C for nine days. Then, the samples were analyzed using both the ferric thiocyanate (FTC) [37] and the thiobarbituric acid reactive species (TBARS) methods [38].…”

Section: Inhibition Of Lipid Peroxidationmentioning

confidence: 99%

Mechanistic investigations on the antioxidant action of a neuroprotective estrogen derivative

et al. 2008

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Antioxidant action is an important component of the complex neuroprotective action of estrogens. Combining theoretical prediction and subsequent experimental confirmation by chemical and in vitro paradigms, this study focused on the mechanistic aspects of hydroxyl-radical scavenging by 17β-butoxy-1,3,5(10)-estratrien-3-ol, a synthetic derivative of 17β-estradiol with increased potency to inhibit lipid peroxidation and reduced affinity to estrogen-receptors compared to the endogenous hormone. In the process that acts as a "chemical shield," the phenolic A-ring turns into 10β-hydroxy-17β-butoxy-1,3,5(10)-estratrien-3-one, a non-aromatic para-quinol, upon capturing hydroxyl-radicals, which results in the complete loss of estrogen-receptor affinity and antioxidant activity. However, the parent compound is apparently recovered in brain tissue from this para-quinol via enzyme-catalyzed NAD(P)H-dependent reductive aromatization without causing oxidative stress. Taken together, our report argues for a previously unrecognized antioxidant cycle for synthetic estrogen-derived compounds.

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“…The mixture was placed in boiling water bath for 10 min. After cooling it was centrifuged for 3000 rpm for 30 min and the absorbance of supernatant was measured at 532 nm [32].…”

Section: Thiobarbituric Acid Test (Tba)mentioning

confidence: 99%

HPLC Analysis and Standardization of Arjunarishta – An Ayurvedic Cardioprotective Formulation

Lal

2009

Sci. Pharm.

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Arjunarishta (Parthadyarishta) is an important Ayurvedic formulation used for cardiovascular disorders and is prepared by fermenting the decoction of specified plant materials using flowers of Woodfordia fruticosa. In present communication, an HPLC-PDA method was developed for the standardization of Arjunarishta by quantitative estimation of major antioxidant compounds, ellagic acid, gallic acid, ethyl gallate, quercetin and kaempferol as markers. The developed method was validated with respect to linearity, precision, accuracy, and robustness. The HPLC analysis showed an increase in amount of ellagic acid and gallic acid during preparation, i.e. decoction vs formulation. A similar increase in free radical scavenging activity of formulation vs decoction was also observed. Arjunolic acid and arjunic acid were not detected in the formulation.

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A novel type of antioxidant isolated from leaf wax of Eucalyptus leaves.

Cited by 291 publications

References 0 publications

DNA scission inhibition, antioxidant, and antiproliferative activities of water chestnut (Trapa natans) extracted in different solvents

DNA scission inhibition, antioxidant, and antiproliferative activities of water chestnut (Trapa natans) extracted in different solvents

Mechanistic investigations on the antioxidant action of a neuroprotective estrogen derivative

HPLC Analysis and Standardization of Arjunarishta – An Ayurvedic Cardioprotective Formulation

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