A Novel Synthesis of Some New Imidazothiazole and Glycocyamidine Derivatives and Studies on Their Antimicrobial Activities

Anticancer Activity Screening of a Series of Imidazo[2,1‐c][1,2,4]triazolone and Imidazo[1,2 ‐b][1,2,4]triazolone Derivatives Synthesized Under Solvent Free Conditions

“…Ring opening, rearrangement and reclosure of 3‐Phenyl‐2‐thioxoimidazolidin‐4‐one derivative 1 to form the key compound 3‐amino‐2‐phenylaminoimidazol‐4‐one 7 was carried out via refluxing with hydrazine hydrate (scheme ). Compound 7 that has active sites for ring annulations was further employed as a building block for our novel imidazo[1,2‐b][1,2,4]triazolone derivatives by fusion with different electrophiles such as ethyl chloroformate to synthesize compound 8 .…”

“…Moreover, some fusion or microwave assisted reactions of triazole derivatives were applied as green synthetic pathways of different imidazo[1,2,4]triazoles. Therefore, in this research a novel series of bridgehead nitrogen heterocycles were based on 5‐(4‐methoxybenzylidene)‐3‐phenyl‐2‐thioxoimidazolidin‐4‐one or 3‐amino‐5‐(4‐methoxybenzylidene)‐2‐(phenylamino)‐3,5‐dihydro‐4H‐imidazol‐4‐one as easily prepared starting substrates from commercially available reagents. Solvent‐free organic synthetic approach was followed as it has been proved to be an eco‐friendly methodology to solve problems in chemical synthesis of various biologically active compounds.…”