Synthesis of new imidazothiazole derivatives and investigation of their anti-inflammatory and analgesic activities

Design, synthesis, and anti-inflammatory activity of indole-2-formamide benzimidazole[2,1-b]thiazole derivatives

“…Synthesis of 6-(3-aminophenyl) imidazole[2,1-b]thiazole-3ethyl formate (9). At room temperature, the tin(II) chloride dihydrate (3.5 g, 15.5 mmol) was carefully added to 25 mL of hydrochloric acid, and the mixture was agitated until it became completely homogeneous.…”

“…The fusion of numerous heterocyclic compounds, including nitrogen and sulfur atoms, plays an essential role in the eld of medicinal chemistry. 8,9 These chemicals are extensively used to treat a broad range of conditions. Indole and imidazole [2,1-b] thiazole derivatives have garnered considerable interest, probably owing to their extensive pharmacological activities.…”

From Bench to Bedside: What Do We Know about Imidazothiazole Derivatives So Far?

“…The Soyer Can group synthesized a series of new formamide compounds with imidazothiazole as the skeleton [ 46 ]. In order to determine the anti-inflammatory activity of the compound on RAW 264.7 cells, a Griess test was conducted [ 79 ].…”

“…Inflammatory cells [46][47][48] Paw edema model [49] Nerves and cardiovascular system [50] Cyclooxygenase-2 (COX-2) [51] Antioxidant activity Excessive free radicals [52,53] Analgesic activity Opioid µ-receptors [54] Therapeutic effect of cardiovascular disease Voltage-gated Ca 2+ channels [55,56]…”