A novel method to quantify carotid artery stenosis by Doppler ultrasound: Using the continuity principle

Wong, Cynthia F.; Wong, Joseph M.

doi:10.1055/s-0031-1278371

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…The velocity and diameter of the vessels were recorded before the arteriotomy and at each time point. The percentage area stenosis was calculated using the following equation, which has been used in previous publications:

true(1 - true[D_{2} \times D_{2} \times V_{2} true] / true[D_{0} \times D_{0} \times V_{1} true] true) \times 100 %

where D 0 is the diameter of the vessel at the patch at the time of euthanasia and D 2 is the diameter of the vessel before patch placement (reference area). V 1 is the peak velocity at the time of euthanasia and V 2 is the peak velocity at the reference area.…”

Section: Methodsmentioning

confidence: 99%

Feasibility of a nanomaterial‐tissue patch for vascular and cardiac reconstruction

et al. 2015

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Vascular and cardiac reconstruction involves the use of biological patches to treat trauma and defects. An in vivo study was performed to determine the remodeling and biologic effects of novel nanostructured vascular patches with and without gold nanoparticles. Porcine vascular tissue was decellularized and conjugated with gold nanoparticles to evaluate if integration would occur while avoiding rupture and stenosis. Swine underwent a bilateral patch angioplasty of the carotid arteries with experimental patches on the right and control patches of bovine pericardium on the left. Animals were sacrificed after surgery and at 3 and 9 weeks. Ultrasound was performed during surgery, every 3 weeks, and before euthanasia. Endothelial regeneration was examined using Evans Blue dye and histology using Trichrome and H&E. There was a 100% success rate of implantation with 0% mortality. All patches were patent on ultrasound. At 3 weeks, experimental patches had regenerating endothelial cell growth and normal healing responses. At 9 weeks, the experimental patches demonstrated excellent integration. Histology demonstrated cellular in-growth into the experimental patches and no major immune reactions. This is one of the first studies to demonstrate the feasibility of nanomaterial-tissue patches for vascular and cardiac reconstruction.

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true(1 - true[D_{2} \times D_{2} \times V_{2} true] / true[D_{0} \times D_{0} \times V_{1} true] true) \times 100 %

Section: Methodsmentioning

confidence: 99%

Feasibility of a nanomaterial‐tissue patch for vascular and cardiac reconstruction

et al. 2015

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“…Digital subtraction angiography (DSA) is the primary imaging modality for evaluating the cerebral arteries in the diagnosis of atherosclerotic stenosis [ 13 , 14 ]. However, DSA is invasive, expensive, and not readily available.…”

Section: Introductionmentioning

confidence: 99%

The Diagnostic Accuracy of Transcranial Color-Coded Doppler Ultrasound Technique in Stratifying Intracranial Cerebral Artery Stenoses in Cerebrovascular Disease Patients: A Systematic Review and Meta-Analysis

Gunda,

Yip,

et al. 2024

JCM

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The early and accurate stratification of intracranial cerebral artery stenosis (ICAS) is critical to inform treatment management and enhance the prognostic outcomes in patients with cerebrovascular disease (CVD). Digital subtraction angiography (DSA) is an invasive and expensive procedure but is the gold standard for the diagnosis of ICAS. Over recent years, transcranial color-coded Doppler ultrasound (TCCD) has been suggested to be a useful imaging method for accurately diagnosing ICAS. However, the diagnostic accuracy of TCCD in stratifying ICASs among patients with CVD remains unclear. Therefore, this systematic review and meta-analysis aimed at evaluating the diagnostic accuracy of TCCD in the stratification of intracranial steno-occlusions among CVD patients. A total of six databases—Embase, CINAHL, Medline, PubMed, Google Scholar, and Web of Science (core collection)—were searched for studies that assessed the diagnostic accuracy of TCCD in stratifying ICASs. The meta-analysis was performed using Meta-DiSc 1.4. The Quality Assessment of Diagnostic Accuracy Studies tool version 2 (QUADAS-2) assessed the risk of bias. Eighteen studies met all of the eligibility criteria. TCCD exhibited a high pooled diagnostic accuracy in stratifying intracranial steno-occlusions in patients presenting with CVD when compared to DSA as a reference standard (sensitivity = 90%; specificity = 87%; AUC = 97%). Additionally, the ultrasound parameters peak systolic velocity (PSV) and mean flow velocity (MFV) yielded a comparable diagnostic accuracy of “AUC = 0.96”. In conclusion, TCCD could be a noble, safe, and accurate alternative imaging technique to DSA that can provide useful diagnostic information in stratifying intracranial steno-occlusions in patients presenting with CVD. TCCD should be considered in clinical cases where access to DSA is limited.

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“…IS patients always have symptoms including inability to move or inconvenience on one side of the body ( 3 ). Techniques, such as a neurological examination, CT scans, MRI scans and Doppler ultrasound, have been used for diagnosis and determining the type and causes of IS ( 4 , 5 ). Current studies found that blood tests and gene detection may help to find the potential causes of IS.…”

Section: Introductionmentioning

confidence: 99%

Smoking and drinking influence the advancing of ischemic stroke disease by targeting PTGS2 and TNFAIP3

Miao

Guo

Zhou³

et al. 2018

Exp Ther Med

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In the present study, we explored the influence of cigarette smoking and alcohol drinking on gene expression level and related functions and pathways on the development of ischemic stroke (IS) disease. The gene expression profile of E-GEOD-22255 was obtained from 20 IS samples (7 patients without smoking or drinking history and 13 patients with smoking or drinking history) and 20 controls (9 normal controls without smoking or drinking history and 11 controls with smoking or drinking history). The correlation degree between gene expression and grouping were measured by significance analysis of microarray (SAM). Smoking or drinking-related DEGs were screened. GO functional and KEGG pathway enrichment analyses were processed. Based on the KEGG database, a pathway relationship network was constructed. DEGs in significant functions and pathways were inserted and regarded as key DEGs. Gene co-expression network was constructed based on the expression value of key genes. In total, 319 IS-related DEGs, which were induced by smoking and drinking, were screened and enriched in various functions and pathways, including inflammatory response, nuclear factor-κB (NF-κB) signaling pathway and influenza A. Pathway relationship network was constructed with 44 nodes and the hub node was the MAPK signaling pathway. After merging, 87 key DEGs were obtained. The gene co-expression network with 43 node edges was constructed and the hub node was prostaglandin-endoperoxide synthase 2. In IS patients, smoking and drinking may induce different expression of many genes, including PTGS2, TNFAIP3, ZFP36 and NFKBIZ. In addition, these genes participated in various pathways, such as inflammatory response.

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A novel method to quantify carotid artery stenosis by Doppler ultrasound: Using the continuity principle

Cited by 5 publications

References 8 publications

Feasibility of a nanomaterial‐tissue patch for vascular and cardiac reconstruction

Feasibility of a nanomaterial‐tissue patch for vascular and cardiac reconstruction

The Diagnostic Accuracy of Transcranial Color-Coded Doppler Ultrasound Technique in Stratifying Intracranial Cerebral Artery Stenoses in Cerebrovascular Disease Patients: A Systematic Review and Meta-Analysis

Smoking and drinking influence the advancing of ischemic stroke disease by targeting PTGS2 and TNFAIP3

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