Feasibility of a nanomaterial‐tissue patch for vascular and cardiac reconstruction

Ostdiek, Allison M.; Ivey, Jan; Hansen, Sarah A.; Gopaldas, Raja R.; Grant, Sheila

doi:10.1002/jbm.b.33410

Cited by 16 publications

(12 citation statements)

References 28 publications

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“…Autogenous veins and xenogeneic and synthetic materials are used as vascular patch materials [50]. As a synthetic patch material, PTFE demonstrated acceptable suture strength and mechanical strength through its ability to resist blood pressure increase [51]. However, it carries the risk of inducing a foreign-body response that leads to chronic inflammation and thrombus formation [52].…”

Section: Discussionmentioning

confidence: 99%

Angioplasty Using 4-Hexylresorcinol-Incorporated Silk Vascular Patch in Rat Carotid Defect Model

Kim

et al. 2018

Applied Sciences

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The aim of this study was to evaluate and compare the efficacy of 4-hexylresorcinol (4-HR)-incorporated silk as a vascular patch scaffold to that of the commercial polytetrafluoroethylene (PTFE) vascular patch (GORE® ACUSEAL). The expression of the vascular endothelial cell growth factor-A (VEGF-A) after application of 4-HR was studied in RAW264.7 and HUVEC cells. In the animal study, a carotid artery defect was modeled in Sprague Dawley rats (n = 30). The defect was directly closed in the control group (n = 10), or repaired with the PTFE or 4-HR silk patch in the experimental groups (n = 10 per group). Following patch angioplasty, angiography was performed and the peak systolic velocity (PSV) was measured to evaluate the artery patency. The application of 4-HR was shown to increase the expression of VEGF-A in RAW264.7 and HUVEC cells. The successful artery patency rate was 80% for the 4-HR silk group, 30% for the PTFE group, and 60% for the control group. The PSV of the 4-HR silk group was significantly different from that of the control group at one week and three weeks post-angioplasty (p = 0.005 and 0.024). Histological examination revealed new regeneration of the arterial wall, and that the arterial diameter was well maintained in the 4-HR silk group in the absence of an immune reaction. In contrast, an overgrowth of endothelium was observed in the PTFE group. In this study, the 4-HR silk patch was successfully used as a vascular patch, and achieved a higher vessel patency rate and lower PSV than the PTFE patch.

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Section: Discussionmentioning

confidence: 99%

Angioplasty Using 4-Hexylresorcinol-Incorporated Silk Vascular Patch in Rat Carotid Defect Model

Kim

et al. 2018

Applied Sciences

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“…There are multiple practical approaches for incorporating different NPs into decellularized matrices; these include immersion, multiple injections, and electron beam-physical vapor deposition. 5,37,38…”

Section: Mechanisms Of Np Binding To Decellularized Matricesmentioning

confidence: 99%

Incorporation of nanoparticles into transplantable decellularized matrices: Applications and challenges

Saleh

Ahmed

et al. 2018

Int J Artif Organs

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Decellularization of tissues can significantly improve regenerative medicine and tissue engineering by producing natural, less immunogenic, three-dimensional, acellular matrices with high biological activity for transplantation. Decellularized matrices retain specific critical components of native tissues such as stem cell niche, various growth factors, and the ability to regenerate in vivo. However, recellularization and functionalization of these matrices remain limited, highlighting the need to improve the characteristics of decellularized matrices. Incorporating nanoparticles into decellularized tissues can overcome these limitations because nanoparticles possess unique properties such as multifunctionality and can modify the surface of decellularized matrices with additional growth factors, which can be loaded onto the nanoparticles. Therefore, in this minireview, we highlight the various approaches used to improve decellularized matrices with incorporation of nanoparticles and the challenges present in these applications.

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“…In another application, decellularized vascular tissue was conjugated with gold nanoparticles and used in patch angioplasty of the carotid artery in mice. The vascular patch with gold nanoparticles showed increased endothelial regeneration and a normal healing response with excellent tissue integration (Ostdiek et al, 2016 ). Both 3D printing and nanoparticle technology have shown promise in the regenerative field but like other biomaterial approaches, they require more research and optimization before they can be clinically employed.…”

Section: Future Directionsmentioning

confidence: 99%

How Biomaterials Can Influence Various Cell Types in the Repair and Regeneration of the Heart after Myocardial Infarction

Lister

Rayner

Suuronen

2016

Front. Bioeng. Biotechnol.

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The healthy heart comprises many different cell types that work together to preserve optimal function. However, in a diseased heart the function of one or more cell types is compromised which can lead to many adverse events, one of which is myocardial infarction (MI). Immediately after MI, the cardiac environment is characterized by excessive cardiomyocyte death and inflammatory signals leading to the recruitment of macrophages to clear the debris. Proliferating fibroblasts then invade, and a collagenous scar is formed to prevent rupture. Better functional restoration of the heart is not achieved due to the limited regenerative capacity of cardiac tissue. To address this, biomaterial therapy is being investigated as an approach to improve regeneration in the infarcted heart, as they can possess the potential to control cell function in the infarct environment and limit the adverse compensatory changes that occur post-MI. Over the past decade, there has been considerable research into the development of biomaterials for cardiac regeneration post-MI; and various effects have been observed on different cell types depending on the biomaterial that is applied. Biomaterial treatment has been shown to enhance survival, improve function, promote proliferation, and guide the mobilization and recruitment of different cells in the post-MI heart. This review will provide a summary on the biomaterials developed to enhance cardiac regeneration and remodeling post-MI with a focus on how they control macrophages, cardiomyocytes, fibroblasts, and endothelial cells. A better understanding of how a biomaterial interacts with the different cell types in the heart may lead to the development of a more optimized biomaterial therapy for cardiac regeneration.

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Feasibility of a nanomaterial‐tissue patch for vascular and cardiac reconstruction

Cited by 16 publications

References 28 publications

Angioplasty Using 4-Hexylresorcinol-Incorporated Silk Vascular Patch in Rat Carotid Defect Model

Angioplasty Using 4-Hexylresorcinol-Incorporated Silk Vascular Patch in Rat Carotid Defect Model

Incorporation of nanoparticles into transplantable decellularized matrices: Applications and challenges

How Biomaterials Can Influence Various Cell Types in the Repair and Regeneration of the Heart after Myocardial Infarction

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