A Novel Gene, CRR9, Which Was Up-Regulated in CDDP-Resistant Ovarian Tumor Cell Line, Was Associated with Apoptosis

No Association of XRCC1 and CLPTM1L Polymorphisms with Non-small Cell Lung Cancer in a Non-Smoking Han Chinese Population

“…Again, previous studies showed that CLPTM1L was mapped to chromosome 5p15.33 and was a lung cancer susceptibility gene (Yamamoto et al, 2001;James et al, 2012). CLPTM1L rs401681 polymorphism was associated with risk of various cancers (Wang et al, 2008;McKay et al, 2008;Rafnar et al, 2009;Zienolddiny et al, 2009), though there were some inconsistent data.…”

Genetic Variations in TERT-CLPTM1L Genes and Risk of Lung Cancer in a Chinese Population

“…As far as we know, this discovery is found for the first time in Chinese population. CLPTM1L gene encodes a predicted transmembrane protein, which has been reported to be involved in cellular response to genotoxic stress and cisplatin resistance (Yamamoto et al, 2001). This gene is widely expressed in different tissues; however, its function is largely unknown.…”

Polymorphisms of TERT and CLPTM1L and the Risk of Hepatocellular Carcinoma in Chinese Males

“…One explanation for this derives from a previous study that speculated that CLPTM1L might be in strong linkage disequilibrium with other potential functional SNPs (Yamamoto et al, 2001;Zhao et al, 2012). In addition, CLPTM1L was reported to be involved in cellular responses to genotoxic stress and cisplatin resistance (James et al, 2012).…”

“…Recent studies have shown that the reactivation of TERT is likely to promote tumor progression and regulate cancer-promoting pathways (Artandi et al, 2010). CLPTM1L encodes a predicted transmembrane protein that was shown to induce apoptosis in cisplatin-resistant cell lines, although the function of CLPTM1L and its role in tumor genesis remains unclear (Yamamoto et al, 2001). …”