Polymorphisms of TERT and CLPTM1L and the Risk of Hepatocellular Carcinoma in Chinese Males

Su, Ling-Yan; Li, Xuelian; Shen, Li; Zhang, Yue; Zhao, Mengmeng; Yin, Zhihua; Su, Hongying; Zhou, Baosen

doi:10.7314/apjcp.2014.15.19.8197

Cited by 11 publications

(8 citation statements)

References 21 publications

(24 reference statements)

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“…The TL is controlled by the interaction of these various telomere-related genes 11. Among these, two novel telomere-associated genes, TERT and CLPTM1L, have been widely studied in cancer research 6,83.…”

Section: Discussionmentioning

confidence: 99%

“… 11 Among these, two novel telomere-associated genes, TERT and CLPTM1L, have been widely studied in cancer research. 6 , 8 TERT gene encodes the catalytic subunit of telomerase reverse transcriptase, and this promoter mutation and dysregulated expression were proved in diverse human malignancies. 3 Our previous study has demonstrated that TERT promoter mutation is frequent in HCC, and TL has some association with age, American Joint Committee on Cancer T stage, OS, and infection status.…”

Section: Discussionmentioning

confidence: 99%

“…There was a previous SNP study of TERT-CLPTM1 locus in HCC demonstrating that the T allele was associated with a significantly increased risk of HCC. 8 …”

Section: Introductionmentioning

confidence: 99%

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<em>TERT-CLPTM1</em> locus polymorphism (rs401681) is associated with the prognosis of hepatocellular carcinoma

Lee

Park

Heo

et al. 2017

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Telomere length is associated with the development of hepatocellular carcinoma (HCC), and recent studies have focused on the genetic alteration or polymorphism in telomere-maintaining genes. We examined the clinicopathologic and prognostic value of rs401681 polymorphism, located in the TERT-CLPTM1L locus, in HCC. The relationship between rs401681 variants and telomere length was also analyzed in 156 HCC patients. The rs401681 polymorphism had the following genotype frequencies: C/C in 51.3% of the samples, C/T in 39.7%, and T/T in 9.0%. Telomeres in the tumor samples were 4.04-fold longer, on average, than the telomeres in matched normal samples (SD =1.32), and there were no differences in telomere length according to rs401681 polymorphism (p=0.802). Our results indicate that the rs401681 C allele was significantly associated with increased T and International Union for Cancer Control stages (p<0.01). Univariate and multivariate survival analyses showed that HCC with C allele had poorer prognosis (p<0.01). In conclusion, our findings suggest that rs401681 is a possible prognostic biomarker for HCC patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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<em>TERT-CLPTM1</em> locus polymorphism (rs401681) is associated with the prognosis of hepatocellular carcinoma

Lee

Park

Heo

et al. 2017

OTT

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“…Among the remaining 51 articles, 13 were 13 were meta-analyses, four were conferences, three reported incomplete data, two had no controls, and one had duplicated data. Finally, 15,837 cases and 19,263 controls of 31 studies in 28 articles were included in this meta-analysis (Savage et al, 2007 ; Choi et al, 2009 ; Liu et al, 2010 ; Chen et al, 2011 ; Ding et al, 2011 ; Gago-Dominguez et al, 2011 ; Jaworowska et al, 2011 ; Hofer et al, 2012 ; Wang et al, 2012 , 2016 ; Li et al, 2013 ; Ma et al, 2013 ; Wu et al, 2013 ; Zhang et al, 2013 , 2014 ; Gao et al, 2014 ; Hashemi et al, 2014 ; Singh et al, 2014 ; Su et al, 2014 ; Yin et al, 2014 ; Zhao et al, 2014 ; Jannuzzi et al, 2015 ; Carkic et al, 2016 ; de Martino et al, 2016 ; Oztas et al, 2016 ; Xing et al, 2016 ; Xiao and He, 2017 ; Yuan et al, 2017 ). The genotyping methods included TaqMan PCR, PCR-RFLP, Sequenom, and LDR.…”

Section: Resultsmentioning

confidence: 99%

“…With regard to hepatocellular carcinoma, the rs2736098 AA genotype was identified as an independent hereditary factor associated with carcinoma susceptibility in the Chinese population by Zhang et al ( 2013 ) and Su et al ( 2014 ). However, another study failed to demonstrate such genetic susceptibility, reporting only a significant association between the rs2736098 GA genotype and TERT promoter mutation-positive tumors compared with the AA genotype (Yuan et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Association Between TERT rs2736098 Polymorphisms and Cancer Risk-A Meta-Analysis

et al. 2018

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Background: Cancer remains a leading cause of death and constitutes an enormous burden on society worldwide. The association between the human telomerase reverse transcriptase (TERT) gene variant rs2736098 polymorphisms and cancer predisposition remain inconclusive.Objective and methods: Databases including Pubmed and Embase were systematically searched from inception to September 15, 2017 to retrieve studies investigating the association between the TERT variant rs2736098 polymorphisms and cancer risk in accordance with previously determined exclusion and inclusion criteria. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were evaluated using random or fixed effects models.Results: Thirty-one case-control studies from 29 articles with 15,837 cases and 19,263 controls were screened out after a systematic search. Pooled analysis demonstrated that the TERT variant rs2736098 G > A polymorphism was significantly correlated with cancer risk in all populations (A vs. G: OR = 1.134, 95% CI = 1.051–1.224, P = 0.001; AA vs. GG: OR = 1.280, 95% CI = 1.087–1.508, P = 0.003; GA vs. GG: OR = 1.125, 95% CI = 1.020–1.240, P = 0.018; GA/AA vs. GG: OR = 1.159, 95% CI = 1.047–1.283, P = 0.004). In the subgroup analysis based on cancer type, the TERT rs2736098 with the A allele was 1.299 times more frequent than that with the G allele (OR = 1.299, 95% CI = 1.216–1.386) under the allelic genetic model in lung cancer, and 1.152 times (OR = 1.152, 95% CI = 1.032–1.286) that in bladder cancer.Conclusions: This meta-analysis demonstrated significant correlations between the TERT variant rs2736098 polymorphisms and cancer susceptibility. The A allele in the rs2736098 G > A polymorphism contributes to susceptibility in many types of cancer, especially lung cancer and bladder cancer.

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TERT Gene rs2736100 and rs2736098 Polymorphisms are Associated with Increased Cancer Risk: A Meta-Analysis

et al. 2021

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Polymorphisms of TERT and CLPTM1L and the Risk of Hepatocellular Carcinoma in Chinese Males

Cited by 11 publications

References 21 publications

<em>TERT-CLPTM1</em> locus polymorphism (rs401681) is associated with the prognosis of hepatocellular carcinoma

<em>TERT-CLPTM1</em> locus polymorphism (rs401681) is associated with the prognosis of hepatocellular carcinoma

Association Between TERT rs2736098 Polymorphisms and Cancer Risk-A Meta-Analysis

TERT Gene rs2736100 and rs2736098 Polymorphisms are Associated with Increased Cancer Risk: A Meta-Analysis

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