Association Between TERT rs2736098 Polymorphisms and Cancer Risk-A Meta-Analysis

Abstract

Background: Cancer remains a leading cause of death and constitutes an enormous burden on society worldwide. The association between the human telomerase reverse transcriptase (TERT) gene variant rs2736098 polymorphisms and cancer predisposition remain inconclusive.Objective and methods: Databases including Pubmed and Embase were systematically searched from inception to September 15, 2017 to retrieve studies investigating the association between the TERT variant rs2736098 polymorphisms and cancer risk in accordance with previously determined exclusion and inclusion criteria. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were evaluated using random or fixed effects models.Results: Thirty-one case-control studies from 29 articles with 15,837 cases and 19,263 controls were screened out after a systematic search. Pooled analysis demonstrated that the TERT variant rs2736098 G > A polymorphism was significantly correlated with cancer risk in all populations (A vs. G: OR = 1.134, 95% CI = 1.051–1.224, P = 0.001; AA vs. GG: OR = 1.280, 95% CI = 1.087–1.508, P = 0.003; GA vs. GG: OR = 1.125, 95% CI = 1.020–1.240, P = 0.018; GA/AA vs. GG: OR = 1.159, 95% CI = 1.047–1.283, P = 0.004). In the subgroup analysis based on cancer type, the TERT rs2736098 with the A allele was 1.299 times more frequent than that with the G allele (OR = 1.299, 95% CI = 1.216–1.386) under the allelic genetic model in lung cancer, and 1.152 times (OR = 1.152, 95% CI = 1.032–1.286) that in bladder cancer.Conclusions: This meta-analysis demonstrated significant correlations between the TERT variant rs2736098 polymorphisms and cancer susceptibility. The A allele in the rs2736098 G > A polymorphism contributes to susceptibility in many types of cancer, especially lung cancer and bladder cancer.

hTERT rs2736098 Genetic Variants and Susceptibility of Hepatocellular Carcinoma with Chronic Hepatitis C in the Egyptian Patients

“…In a study conducted by Zhou et al, [19] , subgroup analysis based on cancer type indicated that the TERT rs2736098 (G>A) polymorphism was associated with HCC, the heterozygous and dominant genetic models supported an increased cancer susceptibility in the population carrying the rs2736098 A allele (GA vs. GG: OR=1.595, 95% CI=1.246-2.042, p=0.000; and GA/AA vs. GG: OR=1.494, 95% CI=1.123-1.987, p=0.006) [19] .…”

Relative Leukocyte Telomere Length and Genetic Variants in Telomere-Related Genes and Serum Levels Role in Age-Related Macular Degeneration

“…Furthermore, a meta-analysis has revealed an association between the allele A at TERT rs2736098 G > A (located on 5p15.33) and cancer development. Besides, the ethnicity-specific effect has also been found while analyzing different subgroups [ 67 ]. Another meta-analysis has shown that allele C at TERT - CLPTM1L rs401681 (located on 5p15.33) was a low-penetrance risk allele for the development of lung, bladder, prostate cancers, and basal cell carcinoma but also a potential protective allele for melanoma and pancreatic cancer [ 68 ].…”

Telomerase reverse transcriptase rs2736098 polymorphism is associated with lung cancer: A meta-analysis

“…Over the past decade, several meta-analyses have revealed the relationship between TERT rs2736098 polymorphism and cancer risk, and previous studies have shown that rs2736098 leads to the occurrence and development of cancer. [20][21][22] However, there is no specific study on lung cancer. Thus, this meta-analysis was performed by including case-control studies to examine the above possible relationship of TERT rs2736098 polymorphism with the lung cancer risk.…”