Genetic Variations in TERT-CLPTM1L Genes and Risk of Lung Cancer in a Chinese Population

Zhao, Mengmeng; Zhang, Yue; Shen, Li; Ren, Yong; Li, Xuelian; Yin, Zhihua; Zhou, Baosen

doi:10.7314/apjcp.2014.15.6.2809

Cited by 18 publications

(16 citation statements)

References 28 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CLPTM1L has been documented to be associated with apoptosis and be upregulated in cisplatin resistant cell lines (Yamamoto et al, 2001). Recently, a few SNPs located in the TERT-CLPTM1L have shown consistent associations with lung cancer (Qi et al, 2012;Zhang et al, 2012;Zhao et al, 2014). In the current case-control study and the meta-analysis, we confirmed the significant inverse association between rs31489 and lung cancer risk both in Caucasians and Asians.…”

Section: Discussionsupporting

confidence: 82%

Genetic Variant in CLPTM1L Confers Reduced Risk of Lung Cancer: a Replication Study in Chinese and a Meta-analysis

Luo¹,

Lamsal²,

Xu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: Rs31489 in the cleft lip and palate transmembrane1-like gene (CLPTM1L) has been identified to be associated with lung cancer through genome-wide association studies (GWAS). However, some recent replication studies yielded inconclusive results. Thus, we undertook this study to investigate the precise effect of rs31489 on lung cancer susceptibility. Materials and Methods: A hospital-based case-control study in 1,673 Chinese subjects (611 individuals with lung cancer and 1,062 controls) and a meta-analysis among 32,199 subjects (16,364 cases and 15,835 controls) were performed in this study. Results: In our case-control study, rs31489 was inversely associated with lung cancer (AC versus CC: OR=0.68, 95%CI=0.52-0.88; additive model: OR=0.68, 95%CI=0.54-0.85; dominant model: OR=0.65, 95%CI =0.51-0.84). Stratification analysis by smoking status showed a significant association and strong genetic effect in non-smokers but not in smokers. Our metaanalysis further confirmed the association, although with significant heterogeneity contributed by study design and source of controls, as shown by stratified analysis. Sensitive and cumulative analyses both indicated robust stability of our results. In addition, there was no observable publication bias in our meta-analysis. Conclusions: Overall, the findings from our replication study and meta-analysis demonstrated that CLPTM1L gene rs31489 is significantly associated with lung cancer.

show abstract

Section: Discussionsupporting

confidence: 82%

Genetic Variant in CLPTM1L Confers Reduced Risk of Lung Cancer: a Replication Study in Chinese and a Meta-analysis

Luo¹,

Lamsal²,

Xu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Recently published studies (4,5) indicate that one such genetic region associated with lung cancer risk is the short arm of chromosome 5 near CLPTM1L and including TERT gene, which was consistently associated with NSCLC in multiple GWAS and replication studies (6)(7)(8)(9). Some population-based studies have focused on the association between TERT gene polymorphism and NSCLC risk in different populations (15)(16)(17)22,23). In a study by Zhao et al (15), they investigated the association between genetic variants of TERT rs2736098 and CLPTM1L rs401681 and lung cancer, with a total of 980 Chinese cases included.…”

Section: Discussionmentioning

confidence: 99%

Case–Control Study on Impact of the Telomerase Reverse Transcriptase Gene Polymorphism and Additional Single Nucleotide Polymorphism (SNP)– SNP Interaction on Non‐Small Cell Lung Cancers Risk in Chinese Han Population

Xing

Liu

et al. 2016

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

“…However, they have distinct genetic background and gene expression patterns according to localization, genotype and aggressiveness [ 22 , 23 ]. Chr5p15.33 harbors a unique cancer susceptibility region that contains at least two plausible candidate genes: TERT and CLTPM1L [ 24 – 27 ]. The TERT gene has been mapped to chromosome 5p15.33 and consisted of 16 exons and 15 introns spanning 35kb of genomic DNA [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic variations in the TERT and CLPTM1L gene region and gastrointestinal stromal tumors risk

Zhang

Zhao

et al. 2015

Oncotarget

View full text Add to dashboard Cite

Recent studies have suggested polymorphisms in the TERT and CLPTM1L region are associated with carcinogenesis of many distinct cancer types, including gastrointestinal cancers. However, the contribution of polymorphisms in the TERT and CLPTM1L gene region to gastrointestinal stromal tumors (GISTs) risk is still unknown. We tested the six tagSNPs on TERT and CLPTM1L region with GIST risk, using a population-based, two-stage, case-control study in 2,000 subjects. Functional validation was conducted to validate our findings of TERT rs2736098 and explore its influence on relative telomere length (RTL) in GIST cells. It showed that variant rs2736098 was significantly associated with increased risk of GIST (per allele OR = 1.29, 95% CI: 1.14–1.47, P = 7.03 × 10−5). The difference remain significant after Bonferroni correction (P = 7.03 × 10−5 * 6 = 4.2 × 10−4). Real-time PCR showed carriers of genotype CC have the longest RTL, following by carriers of genotype CT, while carriers of genotype TT have the shortest RTL in GIST tissues (P < 0.001). Our data provide evidence to implicate TERT rs2736098 polymorphism as a novel susceptibility factor for GIST risk.

show abstract

Genetic Variations in TERT-CLPTM1L Genes and Risk of Lung Cancer in a Chinese Population

Cited by 18 publications

References 28 publications

Genetic Variant in CLPTM1L Confers Reduced Risk of Lung Cancer: a Replication Study in Chinese and a Meta-analysis

Genetic Variant in CLPTM1L Confers Reduced Risk of Lung Cancer: a Replication Study in Chinese and a Meta-analysis

Case–Control Study on Impact of the Telomerase Reverse Transcriptase Gene Polymorphism and Additional Single Nucleotide Polymorphism (SNP)– SNP Interaction on Non‐Small Cell Lung Cancers Risk in Chinese Han Population

Genetic variations in the TERT and CLPTM1L gene region and gastrointestinal stromal tumors risk

Contact Info

Product

Resources

About