Genetic variations in the TERT and CLPTM1L gene region and gastrointestinal stromal tumors risk

Zhang, Rui; Zhao, Jian; Xu, Jian; Liu, Fang; Xu, Yongqing; Bu, Xianmin; Dai, Chaoliu; Song, Chun

doi:10.18632/oncotarget.5153

Cited by 10 publications

(7 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 2015, Zhang et al found that the C allele of rs2736098 was associated with an increased risk of gastrointestinal stromal tumor. 42 However, in the current study, rs2736098 exhibited no association with NSCLC in a Chinese Han population, and this finding is consistent with those of a study of hepatocellular carcinomas by Yuan et al 43 Moreover, the results related to rs2853676, 44 , 45 rs10069690, 46 , 47 rs2075786, 48 , 49 and rs2736122 21 , 50 have exhibited inconsistencies in different studies (including the current study). The reasons for these inconsistencies could be related to the different diseases studied and different genetic backgrounds of the studied populations.…”

Section: Discussionsupporting

confidence: 89%

Genetic polymorphisms in the <em>TERT</em> gene and susceptibility to non-small cell lung cancer in a Chinese Han population

Wang

et al. 2018

CMAR

View full text Add to dashboard Cite

BackgroundRecent studies have revealed that the TERT gene plays crucial roles in cancer initiation and development. Genome-wide analysis studies and case-control studies have demonstrated that polymorphisms in the TERT gene are associated with various cancers.Materials and methodsIn the current study, we analyzed the associations of eight single nucleotide polymorphisms (SNPs) in the TERT gene with non-small cell lung cancer (NSCLC) in a Chinese Han population. A total of 467 NSCLC patients and 526 healthy individuals were recruited for SNP genotyping using a TaqMan assay.ResultsOur results revealed that the allelic frequencies of rs2853677 and rs2853691 were significantly different between the NSCLC and control groups (P=0.004 and 0.001, respectively). Moreover, the T allele of rs2853677 and the A allele of rs2853691 might be the protective factors against NSCLC (OR=0.766; 95%CI: 0.639–0.918 and OR=0.714; 95%CI: 0.584–0.875, respectively). Additionally, stratified association analysis of the eight SNPs with the different pathological NSCLC stages (I+II and III+IV) and different pathological types (adenocarcinoma and squamous cell carcinoma) revealed that none of the SNPs were significantly different between patients with different pathological stages and pathological types.ConclusionOur results indicated that rs2853677 and rs2853691 in the TERT gene might be associated with NSCLC in this Chinese Han population.

show abstract

Section: Discussionsupporting

confidence: 89%

Genetic polymorphisms in the <em>TERT</em> gene and susceptibility to non-small cell lung cancer in a Chinese Han population

Wang

et al. 2018

CMAR

View full text Add to dashboard Cite

show abstract

“…The 45 studies included nine on breast cancer (Garcia‐Closas et al, ; Haiman et al, ; Huo et al, ; Michailidou et al, , ; Palmer et al, ; Purrington et al, ) and, six on ovarian cancer (Bojesen et al, ; Earp et al, ; Kuchenbaecker et al, ; Lee et al, ; Phelan et al, ; Terry et al, ); five on lung cancer (Gao et al, ; Landi et al, ; Wang et al, ; Ye et al, ; Zhao et al, ). two each on glioma (Melin et al, ; Zhao et al, ), thyroid cancer (Gong et al, ; Gudmundsson et al, ), pancreatic cancer (Campa, Rizzato, et al, ; Petersen et al, ), prostate cancer (Panagiotou et al, ; Schumacher et al, ), colorectal cancer (Li et al, ; Pellatt, Wolff, Herrick, Lundgreen, & Slattery, ), RCC (Martino et al, ; Wu, Yan, et al, ), and leukemia (Sheng et al, ; Speedy et al, ); and one each on endometrial cancer (Prescott, McGrath, Lee, Buring, & De Vivo, ), bladder cancer (Rothman et al, ), testicular germ cell tumor (TGCTs) (Schumacher et al, ), melanoma (Llorca‐Cardenosa et al, ), multiple myeloma (Campa, Martino, et al, ), gastrointestinal stromal tumors (GISTs) (Zhang et al, ), non‐Hodgkin's lymphoma (NHL), diffuse Large B‐cell lymphoma (DLBCL), small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) (Shadrina et al, ), nasopharyngeal carcinoma (NPC) (Zhang et al, ), gastric cancer (Duan et al, ), esophageal cancer (Wu, Yan, et al, ), gastric cardia adenocarcinoma (GCA) (Zhang et al, ), hepatocellular carcinoma (HCC) (Zhang et al, ). One study focused on Caucasians (Prescott et al, ); two studies focused on Africans (Huo et al, ; Long et al, ); three studies on African‐Americans (Bojesen et al, ; Haiman et al, ; Palmer et al, ), 16 studies on Asians (Bojesen et al, ; Duan et al, ; Gao et al,…”

Section: Resultsmentioning

confidence: 99%

TERT rs10069690 polymorphism and cancers risk: A meta‐analysis

Song

Zhang

et al. 2019

Molec Gen & Gen Med

View full text Add to dashboard Cite

BackgroundStudies have identified that the telomerase reverse transcriptase (TERT) gene polymorphism rs10069690 (C>T) is associated with cancer risk, but the results remain inconclusive.MethodsTo provide a more precise estimation of the relationship, we performed a meta‐analysis of 45 published studies including 329,035 cases and 730,940 controls. We conducted a search in PubMed, Google Scholar and Web of Science to select studies on the association between rs10069690 and cancer risk. Stratification by ethnicity, cancer type, cancers’ classification, source of control, sample size, and genotype method was used to explore the source of heterogeneity. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were evaluated using random effects models. Sensitivity, publication bias, false‐positive report probability (FPRP) and statistical power were also assessed.ResultsThe result demonstrated that rs10069690 was significantly associated with an increased risk of cancer overall (OR = 1.09, 95% CI: 1.06–1.12, p < .001) under the allele model. Stratification analysis revealed an increased cancer risk in subgroups of breast cancer, ovarian cancer, lung cancer, thyroid cancer, and renal cell carcinoma (RCC). However, a significantly decreased association was observed in pancreatic cancer in the European population (OR = 0.93,95% CI: 0.87–0.99, p = .031). In the subgroup analysis based on cancer type, no significant association was found in prostate cancer, leukemia, colorectal cancer and glioma.ConclusionsThis meta‐analysis suggested that the TERT rs10069690 polymorphism may be a risk factor for cancer, especially breast cancer, ovarian cancer, lung cancer, thyroid cancer, and RCC. Further functional studies are warranted to reveal the role of the polymorphism in carcinogenesis.

show abstract

“…Interestingly we found that SORE6+ cells have increased expression of two genes known to enhance resistance to drugs by different mechanisms. CLPTM1L, also known as cisplatin resistance-related protein 9, confers resistance to apoptosis caused by genotoxic agents and leads to up-regulation of the anti-apoptotic protein, Bcl-xL [66,67]. CYP3A5 encodes a member of the cytochrome P450 superfamily of enzymes, which have multiple functions in drug metabolism and in facilitating the elimination of drugs [68].…”

Section: Discussionmentioning

confidence: 99%

A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin

Pádua

Barros

Amaral

et al. 2020

Cancers

View full text Add to dashboard Cite

Gastric cancer remains a serious health burden with few therapeutic options. Therefore, the recognition of cancer stem cells (CSCs) as seeds of the tumorigenic process makes them a prime therapeutic target. Knowing that the transcription factors SOX2 and OCT4 promote stemness, our approach was to isolate stem-like cells in human gastric cancer cell lines using a traceable reporter system based on SOX2/OCT4 activity (SORE6-GFP). Cells transduced with the SORE6-GFP reporter system were sorted into SORE6+ and SORE6– cell populations, and their biological behavior characterized. SORE6+ cells were enriched for SOX2 and exhibited CSC features, including a greater ability to proliferate and form gastrospheres in non-adherent conditions, a larger in vivo tumor initiating capability, and increased resistance to 5-fluorouracil (5-FU) treatment. The overexpression and knockdown of SOX2 revealed a crucial role of SOX2 in cell proliferation and drug resistance. By combining the reporter system with a high-throughput screening of pharmacologically active small molecules we identified monensin, an ionophore antibiotic, displaying selective toxicity to SORE6+ cells. The ability of SORE6-GFP reporter system to recognize cancer stem-like cells facilitates our understanding of gastric CSC biology and serves as a platform for the identification of powerful therapeutics for targeting gastric CSCs.

show abstract

Genetic variations in the TERT and CLPTM1L gene region and gastrointestinal stromal tumors risk

Cited by 10 publications

References 38 publications

Genetic polymorphisms in the <em>TERT</em> gene and susceptibility to non-small cell lung cancer in a Chinese Han population

Genetic polymorphisms in the <em>TERT</em> gene and susceptibility to non-small cell lung cancer in a Chinese Han population

TERT rs10069690 polymorphism and cancers risk: A meta‐analysis

A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin

Contact Info

Product

Resources

About