Case–Control Study on Impact of the Telomerase Reverse Transcriptase Gene Polymorphism and Additional Single Nucleotide Polymorphism (<scp>SNP</scp>)– <scp>SNP</scp> Interaction on Non‐Small Cell Lung Cancers Risk in Chinese Han Population

Xing, Yanli; Liu, Feng; Li, Jianfeng; Lin, Jianwen; Zhu, Guodong; Li, Ming; Zhang, Changran; Niu, Yuanyuan

doi:10.1002/jcla.21982

Cited by 19 publications

(20 citation statements)

References 22 publications

(35 reference statements)

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“…Previous epidemiologic studies indicated that cigarette smoking was an independent risk factor for gastric cancer development [14, 15]. It has been increasingly accepted that the etiology of most common tumors involves not only genetic, but environmental causes, or interactions between the two.…”

Section: Discussionmentioning

confidence: 99%

“…Cigarette smoking compromises the immune system by suppressing the activation of immune cells and increasing susceptibility to infections. Several studies have confirmed the association between smoking and GC risk [14, 15]. Several studies also reported association of gene- smoking interactions with GC risk, however no study focused on impact of TERT gene - smoking interactions on GC risk.…”

Section: Introductionmentioning

confidence: 99%

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Polymorphisms in human telomerase reverse transcriptase (hTERT) gene, gene- gene and gene-smoking interaction with susceptibility to gastric cancer in Chinese Han population

Zhang

Gao

et al. 2017

Oncotarget

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AimsTo investigate the association of telomerase reverse transcriptase (TERT) gene polymorphisms and additional gene-gene and gene- environment interaction with gastric cancer (GC) risk.ResultsGC risk was significantly higher in carriers of G allele of rs2736100 than those with TT genotype (TG+ GG versus TT), adjusted OR (95%CI) =1.68 (1.26-2.17), and higher in carriers of G allele of rs2853669 than those with AA genotype (AG+ GG versus AA), adjusted OR (95%CI) = 1.72 (1.19-2.33). We also found that interaction between rs2736100 and smoking was associated with higher GC risk. Smokers with TG or GG of rs2736100 genotype have elevated GC risk, compared to never- smokers with TT of rs2736100 genotype, OR (95%CI) = 3.12 (1.82 -4.61). Pairwise linkage equilibrium (LD) analysis between SNPs was measured and the D’ value between rs2736100 and rs2736109 was more than 0.8. A haplotype containing the rs2736100- G and rs2736109- A alleles was associated with a statistically increased GC risk (OR= 2.66, 95%CI= 1.28 – 4.12, p<0.0001).Materials and MethodsA total of 1088 participants (686 males, 402 females) were selected, including 360 GC patients and 728 normal participants. Logistic regression was performed to investigate association between single nucleotide polymorphisms (SNPs) within TERT gene and GC susceptibility. Generalized multifactor dimensionality reduction (GMDR) model was used to screen gene- gene and gene- environment interaction combinations.ConclusionsWe found that G allele of rs2736100 and G allele of rs2853669 in TERT gene, interaction between rs2736100 and smoking, and haplotype containing the rs2736100- G and rs2736109- A alleles were all associated with increased GC risk.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polymorphisms in human telomerase reverse transcriptase (hTERT) gene, gene- gene and gene-smoking interaction with susceptibility to gastric cancer in Chinese Han population

Zhang

Gao

et al. 2017

Oncotarget

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“…Meta-analysis results. Based on the inclusion criteria, a total of 17 studies from 14 previously published articles (15,(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) along with the present study results were analyzed for the association between the TERT rs2583669 polymorphism and cancer susceptibility; this included 9,537 cancer cases and 12,370 controls (Table V). By pooling all the previous studies, a statistically significant association between the TERT rs2583669 polymorphism and cancer risk was identified (dominant model: Pooled OR=1.09; 95% CI, 1.03-1.16; P=0.004; Fig.…”

Section: Frequency Of Rs2853669 In South Indian Cervical Cancermentioning

confidence: 99%

Association between functional TERT promoter polymorphism rs2853669 and cervical cancer risk in South Indian women

et al. 2020

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A single nucleotide polymorphism (SNP) rs2853669 (A>G) in the telomerase reverse transcriptase (TERT) promoter has recently been reported in chr5:1,295,349 T>C (T349C), and was shown to be associated with increased cancer risk and poor survival in a specific population. However, at present, the role of this particular SNP with TERT promoter driver mutations and its genetic association with human papilloma virus (HPV) in patients with cervical cancer has not been determined. In the present study, the genetic association of the functional SNP rs2853669 in the presence/absence of TERT promoter hotspot mutations and HPV in patients with cervical cancer of South Indian origin was evaluated. To understand and compare the frequency of the variant allele and its risk association in different cancer types of various populations, the SNP was genotyped in 257 cervical cancer samples and 295 controls, and its associations with TERT promoter hotspot mutations and HPV were analyzed. Furthermore, an extensive search of previously published articles in PubMed, Embase and Web of Science was conducted; a meta-analysis was carried out to elucidate the association of the SNP with different cancer types in global populations. The SNP analysis showed significantly high frequency (41%) of homozygous variant allele rs2853669 (GG) in patients with cervical cancer compared with control samples [Recessive allele model odds ratio (OR)=1.71; 95% CI=1.20-2.43; P=0.003]. No significant interaction was observed between the TERT SNP rs2853669 and HPV status as well as other hotspot TERT promoter (C228T and C250T) mutations determined in our previous study. In addition, the overall meta-analysis revealed a significant association of the SNP rs2853669 with other cancer types in different ethnic populations (OR=1.09; 95% CI=1.03-1.16; P= 0.004). The present results suggested that the TERT SNP rs2853669 could play an important role in the risk of cervical cancer in a South Indian population.

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“…Increasing cancer susceptibility was observed in Asians, but not for Caucasians, when stratified by ethnicity. Consistently, three lung cancer studies [ 26 – 28 ] were conducted in Asians, thus an increased risk was observed in the allelic comparison (C vs. T), homozygote comparison (CC vs. TT) and recessive model (CC vs. CT+TT). This finding suggests that different populations might have different tumorigenesis mechanisms.…”

Section: Discussionmentioning

confidence: 56%

“…Blood samples were used for genotyping in all studies. Among all fifteen studies, 5 studies focused on breast cancer [ 21 – 25 ], three studies focused on lung cancer [ 26 – 28 ], and one study each focused on gastric cancer [ 16 ], prostate cancer [ 23 ], AML [ 20 ], glioblastoma [ 19 ], colorectal cancer [ 17 ] and SCCHN [ 18 ]. The cancer types were also definitively confirmed through histological or pathological analyses among all studies.…”

Section: Resultsmentioning

confidence: 99%

Association between TERT rs2853669 polymorphism and cancer risk: A meta-analysis of 9,157 cases and 11,073 controls

Liu

Wang

et al. 2018

PLoS ONE

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BackgroundIt has been reported that the functional telomerase reverse transcriptase (TERT) rs2853669 polymorphism might contribute to different types of human cancer. However, the association of this mutation with cancer remains controversial. Here, we conducted a meta-analysis to characterize this relationship.Materials and methods/Main resultsA systematic search of studies on the association of TERT rs2853669 polymorphism with all types of cancer was conducted in PubMed, Embase and Cochrane Library. The summary odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were used to pool the effect size in a fixed-effects model or a random-effects model where appropriate. A total of 13 articles and 15 case-control studies, including 9,157 cases and 11,073 controls, were included in this meta-analysis. Overall, the pooled results indicated that the rs2853669 polymorphism was significantly associated with increased cancer risk in a homozygote comparison model (CT vs. TT: OR = 1.085, 95% CI: 1.015–1.159, P = 0.016). In the stratified analyses, a significant increased cancer risk was observed in Asian, but not Caucasian patients. A subgroup analysis by cancer type also revealed a significant increase in the risk of lung cancer, but not breast cancer.ConclusionsThe results of this meta-analysis suggest that the TERT rs2853669 polymorphism is associated with a significantly increased risk of cancer, particularly lung cancer, in Asian populations.

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Case–Control Study on Impact of the Telomerase Reverse Transcriptase Gene Polymorphism and Additional Single Nucleotide Polymorphism (SNP)– SNP Interaction on Non‐Small Cell Lung Cancers Risk in Chinese Han Population

Abstract: Minor allele of rs2736098 and rs2736100 in TERT gene and interaction between the two SNP were associated with increased risk of NSCLC risk.

Cited by 19 publications

References 22 publications

Polymorphisms in human telomerase reverse transcriptase (hTERT) gene, gene- gene and gene-smoking interaction with susceptibility to gastric cancer in Chinese Han population

Polymorphisms in human telomerase reverse transcriptase (hTERT) gene, gene- gene and gene-smoking interaction with susceptibility to gastric cancer in Chinese Han population

Association between functional TERT promoter polymorphism rs2853669 and cervical cancer risk in South Indian women

Association between TERT rs2853669 polymorphism and cancer risk: A meta-analysis of 9,157 cases and 11,073 controls

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