No Association of XRCC1 and CLPTM1L Polymorphisms with Non-small Cell Lung Cancer in a Non-Smoking Han Chinese Population

Abstract

Background: This study aimed to explore potential associations between single nucleotide polymorphisms (SNPs) of the x-ray repair cross-complementing group 1 (XRCC1) and cleft lip and palate transmembrane protein 1-like (CLPTM1L) and non-small cell lung cancer (NSCLC) susceptibility in non-smoker Chinese patients. Methods: A total of 200 NSCLC patients and 200 healthy controls with matched age and gender were recruited for genotyping of XRCC1 SNPs (rs2256507 and rs1001581) and CLPTM1L SNPs (rs401681 and rs4975616). Association of these SNPs with NSCLC risk was evaluated by computing the odds ratio (OR) and 95% confidence interval (CI) from multivariate unconditional logistic regression analyses with adjustment for gender and age. Results: The frequencies of genotype and allele in these four loci (rs2256507, rs1001581, rs401681, and rs4975616) were not significantly different between the cases and controls, or between either of the histological subgroups (adenocarcinoma and squamous cell carcinoma) and controls. Conclusions: Although these SNPs are associated with NSCLC risk in patients with a tobacco-smoking habit, this study demonstrated that XRCC1 and CLPTM1L gene SPNs are not linked with NSCLC risk in non-smoking patients, indicating that molecular mechanisms of NSCLC betwee tobacco smokers and non-smokers may be different. Future studies are needed to uncover the underlying molecular mechanisms for NSCLC in non-smokers.

Genetic Variations in TERT-CLPTM1L Genes and Risk of Lung Cancer in a Chinese Population

“…However, it was recently reported that rs401681 CT genotype was showed protective effect on lung cancer risk in Asian populations (Bae et al, 2012;Chen et al, 2012). In contrast to above studies, Zienolddiny et al (2009) and Sun et al (2013) did not find any significant association between rs401681 and lung cancer. Base on our research, the rs401681 polymorphism may not affect individual susceptibility to lung cancer.…”

Interaction of XRCC1 and XPD Gene Polymorphisms with Lifestyle and Environmental Factors Regarding Susceptibility to Lung Cancer in a High Incidence Population in North East India

“…In present study, no significant independent association of XRCC1 and XPD polymorphisms for LC was observed. These findings are concordant with some of the previous reports over different ethnic population (David-Beabes et al, 2001;Huang et al, 2008;Sun et al, 2013). However present study reveals significant association when XRCC1 Gln/Gln genotype interact with exposure of wood combustion, exposure of COF and tobacco smoking, while XPD Gln/Gln genotype with betel quid chewing and tobacco smoking.…”

Tankyrase 2 (TNKS2) polymorphism associated with risk in developing non-small cell lung cancer in a Chinese population

“…Most NSCLC cases are diagnosed at advanced stages of the disease, leading to poor five-year survival rate (16% overall survival rate) [2]. In previous studies, we demonstrated that NSCLC risk is present in different ethnic groups [3][4][5][6][7][8]. These data indicate that genetic susceptibility is the most important factor in lung cancer development and contributes to individual lung cancer risk.…”