A novel flavanone derivative inhibits dengue virus fusion and infectivity

Srivarangkul, Pimsiri; Yuttithamnon, Wanchalerm; Suroengrit, Aphinya; Pankaew, Saran; Hengphasatporn, Kowit; Rungrotmongkol, Thanyada; Phuwapraisirisan, Preecha; Ruxrungtham, Kiat; Boonyasuppayakorn, Siwaporn

doi:10.1016/j.antiviral.2018.01.010

Cited by 27 publications

(63 citation statements)

References 50 publications

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“…Several classes of flavonoids have been reported to present dengue antiviral activity specially flavanones, flavones and flavonols . The flavanone ( 27 ), previously isolated by us from the leaves of these three Faramea spp., showed a dose‐dependent reduction in viral load (IC 50 = 13.1 μg/mL) and the ability to control DENV‐2 replication .…”

Section: Resultsmentioning

confidence: 99%

“…12,13 Several classes of flavonoids have been reported to present dengue antiviral activity specially flavanones, flavones and flavonols. 6,7,[45][46][47][48][49] The flavanone (27), previously isolated by us from the leaves of these three Faramea spp., showed a dose-dependent reduction in viral load (IC 50 = 13.1 μg/mL) and the ability to control DENV-2 replication. 13 However, by a bioassay guided fractionation, the flavanones (6 and 13), as well as the flavonols (9 and 26) were previously isolated from the leaves of F. hyacinthina and/or F. truncata from non-cytotoxic but non-cytoprotective fractions.…”

Section: Quantification Of the Polyphenolic Compoundsmentioning

confidence: 99%

“…The structural elucidation of the secondary metabolites, the quantitative analysis of these compounds and the study of their biological activities and functions have promoted the development of several areas of science. Nowadays, the advances of analytical techniques together with the knowledge of a large number of information on natural compounds have allowed metabolic profiles to be established and substances in complex natural matrices to be indentified …”

Section: Introductionmentioning

confidence: 99%

“…Nowadays, the advances of analytical techniques together with the knowledge of a large number of information on natural compounds have allowed metabolic profiles to be established and substances in complex natural matrices to be indentified. 7 The genus Faramea Aubl. (Rubiaceae) comprises c. 200 species of shrubs, sub-shrubs or trees distributed throughout the Neotropics from Mexico to northern Argentina with 123 species occurring in Brazil.…”

Section: Introductionmentioning

confidence: 99%

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Comprehensive characterisation of polyphenols in leaves and stems of three anti‐dengue virus type‐2 active Brazilian Faramea species (Rubiaceae) by HPLC‐DAD‐ESI‐MS/MS

Wolff

Berrueta

Valente

et al. 2018

Phytochemical Analysis

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Section: Resultsmentioning

confidence: 99%

Section: Quantification Of the Polyphenolic Compoundsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comprehensive characterisation of polyphenols in leaves and stems of three anti‐dengue virus type‐2 active Brazilian Faramea species (Rubiaceae) by HPLC‐DAD‐ESI‐MS/MS

Wolff

Berrueta

Valente

et al. 2018

Phytochemical Analysis

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“…5-Hydroxy-7-methoxy-6-methylflavanone (3) has been found in other members of the family Myrtaceae, including Heteropyxis natalensis from South Africa (Maroyi 2019), Syzygium samarangense from Thailand (Srivarangkul et al 2018), and L. scoparium from New Zealand (Mayer 1990;Häberlein and Tschiersch 1998). Antimicrobial properties of this compound are currently unknown, but it has been shown to inhibit dengue virus infectivity (Srivarangkul et al 2018).…”

Section: Kānuka Chemistrymentioning

confidence: 99%

Mātauranga-guided screening of New Zealand native plants reveals flavonoids from kānuka (Kunzea robusta) with anti-Phytophthora activity

Lawrence

Burgess

Pairama³

et al. 2019

Journal of the Royal Society of New Zealand

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Kauri is an ecologically important and culturally treasured tree species in Aotearoa New Zealand. It is under threat from the pathogenic oomycete Phytophthora agathidicida, which causes kauri dieback disease. We hypothesised that mātauranga Māori (Māori knowledge) of kauri forest health could be used to identify native plants that produce anti-Phytophthora compounds. We tested this hypothesis by using knowledge descended from Te Whare Wananga o Ngāpuhi to select and screen four native plants for activity against P. agathidicida and also P. cinnamomi (a broad host-range pathogen). Extracts of kānuka (Kunzea robusta) were active against various life cycle stages. Bioassay-directed isolation led to three flavanones, previously unreported from New Zealand Kunzea, as the main bioactives. These compounds have not previously been reported as having anti-Phytophthora activities. They inhibited P. agathidicida zoospore germination with IC 50 values of 1.4-6.5 µg/mL, making them the most potent inhibitors reported against this stage of the life cycle. The three flavanones also inhibited zoospore motility at 2.5-5.0 µg/mL, and showed some inhibition of mycelial growth at 100 µg/mL. They were generally less active against P. cinnamomi. Overall, the results from this study emphasise the value of using mātauranga Māori in the response to kauri dieback. ARTICLE HISTORY

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A systematic review on phytochemicals for the treatment of dengue

Ali¹,

Chorsiya

Anjum

et al. 2020

Phytotherapy Research

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Dengue fever is prevalent in subtopic regions, producing mortality and morbidity worldwide, which have been of major concern to different governments and World Health Organization. The search of new anti‐dengue agents from phytochemicals was assumed to be highly emergent in past. The phytochemicals have been used in wide distribution of vector ailments such as malaria. The demand of the phytochemicals is based on the medicines which are mostly considered to be safer, less harmful than synthetic drugs and nontoxic. This review mentions majorly about the phytochemicals potentially inhibiting dengue fever around the world. The phytochemicals have been isolated from different species, have potential for the treatment of dengue. Different crude extracts and essential oils obtained from different species showed a broad activity against different phytochemicals. The current studies showed that natural products represent a rich source of medicines toward the dengue fever. Furthermore, ethnobotanical surveys and laboratory investigation established identified natural plants species in the development of drug discovery to control the dengue fever.

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A novel flavanone derivative inhibits dengue virus fusion and infectivity

Cited by 27 publications

References 50 publications

Comprehensive characterisation of polyphenols in leaves and stems of three anti‐dengue virus type‐2 active Brazilian Faramea species (Rubiaceae) by HPLC‐DAD‐ESI‐MS/MS

Comprehensive characterisation of polyphenols in leaves and stems of three anti‐dengue virus type‐2 active Brazilian Faramea species (Rubiaceae) by HPLC‐DAD‐ESI‐MS/MS

Mātauranga-guided screening of New Zealand native plants reveals flavonoids from kānuka (Kunzea robusta) with anti-Phytophthora activity

A systematic review on phytochemicals for the treatment of dengue

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