Teprotumumab (TPT) is a type I insulinlike growth factor receptor inhibitor, marketed as Tepezza; recently USFDA approved it for the treatment of thyroid eye disease (thyroid-associated ophthalmopathy (TAO), Graves ophthalmopathy/ orbitopathy) in the USA. It is a monoclonal antibody although it was initially developed in collaboration with Genmab and Roche for the treatment of the tumour, but later it was investigated by River Vision Development Corporation and Horizon Therapeutics for its ophthalmic use. The drug has been designated as an orphan drug, breakthrough designation and fasttrack designation. This review summarizes the milestones in the research and development including ongoing, clinical trial of TPT till now, foremost to this primary approval for thyroid-associated ophthalmopathy (TAO).
Dengue fever is prevalent in subtopic regions, producing mortality and morbidity worldwide, which have been of major concern to different governments and World Health Organization. The search of new anti‐dengue agents from phytochemicals was assumed to be highly emergent in past. The phytochemicals have been used in wide distribution of vector ailments such as malaria. The demand of the phytochemicals is based on the medicines which are mostly considered to be safer, less harmful than synthetic drugs and nontoxic. This review mentions majorly about the phytochemicals potentially inhibiting dengue fever around the world. The phytochemicals have been isolated from different species, have potential for the treatment of dengue. Different crude extracts and essential oils obtained from different species showed a broad activity against different phytochemicals. The current studies showed that natural products represent a rich source of medicines toward the dengue fever. Furthermore, ethnobotanical surveys and laboratory investigation established identified natural plants species in the development of drug discovery to control the dengue fever.
Fernandoa adenophylla (Heterophragma adenophyllum), commonly known as Dhopa-phali, Ziron, Mostanphul,
Lotum-poh and Karen wood of family Bignoniaceae, has been used traditionally for snakebite (Morigaon district of
Assam, India), hemorrhoids and constipation (Chakma tribe, Bangladesh) and skin disorder (Thai traditional medicine).
This review covers pharmacognostic, phytochemical, and pharmacological as well as the traditional aspect of the plant
and enlightens possible pharmacological activities Received: that can be assessed in the future. Fernandoa adenophylla has
been reported to constitute potent phytochemicals like novel napthaquinones, their derivatives (dilapachone, adenophyllone,
peshwaraquinone, lapachol, and indadone) and triterpenoids (β-sitosterol, β-amyrin, ursolic acid, and oleanolic
acid) which have potential pharmacological activities assessed and reported. The Crude extract of Fernandoa adenophylla
has already been tested for pharmacological properties like antimicrobial, antifungal, anti-TB, and antihypertensive and
leishmanicidal activities. Since not many researches have been carried out on Fernandoa adenophylla, it paves way for
researchers to explore its potential in the field of medicinal plants
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