A systematic review on phytochemicals for the treatment of dengue

Ali, Faraat; Chorsiya, Anushma; Anjum, Varisha; Khasimbi, Shaik; Ali, Akhter

doi:10.1002/ptr.6917

Cited by 16 publications

(11 citation statements)

References 163 publications

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“…9,10 According to several studies, recovery from DENV infection is associated with permanent immunity against that serotype, whereas infection with different serotypes results in only transitory and partial protection, increasing the risk of severe dengue. 11 Indicators of dengue fever are similar to those of the common cold and influenza; that is why people get confused with the treatment of dengue. It can damage the liver by increasing the liver enzymes.…”

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confidence: 99%

Recent outbreak of dengue in Bangladesh: A threat to public health

Bhowmik

Ferdous

Baral

et al. 2023

Health Science Reports

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Background and Aims The dengue virus is widespread throughout Bangladesh and significantly contributes to morbidity and mortality. One effective method for preventing further dengue epidemics is to reduce mosquito breeding at the most opportune period each year. This study aims to determine dengue prevalence in 2022 by comparing previous years' data and estimating the period of this disease's most significant incidence. Methods From the beginning of 2008–December 15, 2022, we looked at the monthly reports of cases made to the Bangladesh Institute of Epidemiology, Disease Control, and Research. Results According to our findings, there were 61089 confirmed dengue cases in 2022, with 269 fatalities ‐ the highest annual death toll for this disease since 2000. Almost one‐third (32.14%) of all dengue deaths in Bangladesh occurred in 2022 (1 January–15 December), highlighting the severity of the threat posed by this disease in the coming year. Furthermore, we observe that the months in the second half of any year in Bangladesh are the most at risk for dengue transmission. In 2022, Dhaka city and Chittagong are hit the hardest (incidence: 63.07% vs. 14.42%; morality: 63.34% vs. 24.16%), showing the relevance of population density in spreading this fatal disease. Conclusion Statistics show an increase in dengue cases every day, and the year 2022 will be marked as the peak of the disease's death prevalence. Both the individuals and the government of Bangladesh need to take action to reduce the dissemination of this epidemic. If not, the country will soon be in great peril.

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confidence: 99%

Recent outbreak of dengue in Bangladesh: A threat to public health

Bhowmik

Ferdous

Baral

et al. 2023

Health Science Reports

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“…With no commercial antivirals available for public use against the Dengue virus and severe Dengue infections leading to conditions such DHF and DSS, the discovery of potential anti-DENV agents is still a pressing issue. Drugs used to treat other conditions, such as the anti-pyretic drug Acetaminophen and the anti-hepatitic Sofosbuvir, were also shown to reduce the Dengue infection symptoms to some extent [ 121 , 122 ]. The vaccine Dengvaxia which was given the license for use in about 20 countries recently began to show some complications in seronegative patients [ 123 ].…”

Section: Antivirals Against Dengue Infectionmentioning

confidence: 99%

Dengue Virus Infection: A Tale of Viral Exploitations and Host Responses

Nanaware

Banerjee

Bagchi

et al. 2021

Viruses

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Dengue is a mosquito-borne viral disease (arboviral) caused by the Dengue virus. It is one of the prominent public health problems in tropical and subtropical regions with no effective vaccines. Every year around 400 million people get infected by the Dengue virus, with a mortality rate of about 20% among the patients with severe dengue. The Dengue virus belongs to the Flaviviridae family, and it is an enveloped virus with positive-sense single-stranded RNA as the genetic material. Studies of the infection cycle of this virus revealed potential host targets important for the virus replication cycle. Here in this review article, we will be discussing different stages of the Dengue virus infection cycle inside mammalian host cells and how host proteins are exploited by the virus in the course of infection as well as how the host counteracts the virus by eliciting different antiviral responses.

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“…Herein lays the promise of natural compounds. With their anticipated minimal side effects, widespread availability, and potential efficacy, natural compounds emerge as beacons of hope, particularly for economically challenged nations [ 4 ]. Numerous studies have unveiled the antiviral prowess of various phytonutrients against pathogens such as the dengue virus (DENV) and chikungunya virus (CHIKV).…”

Section: Introductionmentioning

confidence: 99%

“…Numerous studies have unveiled the antiviral prowess of various phytonutrients against pathogens such as the dengue virus (DENV) and chikungunya virus (CHIKV). Among these bioactive compounds are polysaccharides, alkaloids, terpenoids, terpenes, and flavonoids [ 4 ]. Interestingly, medicinal plants have showcased superior anti-DENV and CHIKV activity when compared to their synthetic counterparts [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Therapeutic Potential of Traditional Antimalarial and Antidengue Plants: A Mechanistic Perspective

Kamaraj,

Ragavendran,

Prem

et al. 2023

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Malaria, a highly perilous infectious disease, impacted approximately 230 million individuals globally in 2019. Mosquitoes, vectors of over 10% of worldwide diseases, pose a significant public health menace. The pressing need for novel antimalarial drugs arises due to the imminent threat faced by nearly 40% of the global population and the escalating resistance of parasites to current treatments. This study comprehensively addresses prevalent parasitic and viral illnesses transmitted by mosquitoes, leading to the annual symptomatic infections of 400 million individuals, placing 100 million at constant risk of contracting these diseases. Extensive investigations underscore the pivotal role of traditional plants as rich sources for pioneering pharmaceuticals. The latter half of this century witnessed the ascent of bioactive compounds within traditional medicine, laying the foundation for modern therapeutic breakthroughs. Herbal medicine, notably influential in underdeveloped or developing nations, remains an essential healthcare resource. Traditional Indian medical systems such as Ayurveda, Siddha, and Unani, with a history of successful outcomes, highlight the potential of these methodologies. Current scrutiny of Indian medicinal herbs reveals their promise as cutting-edge drug reservoirs. The propensity of plant-derived compounds to interact with biological receptors positions them as prime candidates for drug development. Yet, a comprehensive perspective is crucial. While this study underscores the promise of plant-based compounds as therapeutic agents against malaria and dengue fever, acknowledging the intricate complexities of drug development and the challenges therein are imperative. The journey from traditional remedies to contemporary medical applications is multifaceted and warrants prudent consideration. This research aspires to offer invaluable insights into the management of malaria and dengue fever. By unveiling plant-based compounds with potential antimalarial and antiviral properties, this study aims to contribute to disease control. In pursuit of this goal, a thorough understanding of the mechanistic foundations of traditional antimalarial and antidengue plants opens doors to novel therapeutic avenues.

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A systematic review on phytochemicals for the treatment of dengue

Cited by 16 publications

References 163 publications

Recent outbreak of dengue in Bangladesh: A threat to public health

Recent outbreak of dengue in Bangladesh: A threat to public health

Dengue Virus Infection: A Tale of Viral Exploitations and Host Responses

Exploring the Therapeutic Potential of Traditional Antimalarial and Antidengue Plants: A Mechanistic Perspective

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