A novel calix[4]arene thiol functionalized silver nanoprobe for selective recognition of ferric ion with nanomolar sensitivity via DLS selectivity in human biological fluid

Abstract

A high concern for human health and safety has motivated dynamic research on the potential impact of transition metal ions and their toxic effects, thus it is very challenging to design transition-metal ion detection devices that are cost-effective, rapid and applicable to the biological milieus. Driven by the need to detect trace amounts of Fe(3+) from blood samples, we report a highly selective and ultrasensitive calix[4]arene modified silver nanoprobe for Fe(3+) recognition at the 9.4 nM level from aqueous solution with excellent discrimination against other heavy metals and biomolecules. The assembly was characterized by TEM (transmission electron microscopy), DLS (dynamic light scattering), UV-Vis, FT-IR, ESI-MS and (1)H NMR spectrometry, which demonstrate the higher binding affinity for Fe(3+). The biosensor has been successfully applied to estimate the ferric ion in human blood serum as well as in human hemoglobin.

Organic frameworks confined Cu single atoms and nanoclusters for tandem electrocatalytic CO2 reduction to methane

“…The in situ ATR-FTIR spectra (Figure 3B) scanned from 0.6 V RHE to −1.4 V RHE displayed a gradual increase at the peak of 1160 cm −1 , which can be assigned to the formation of C-O-K bonds. 38,40,41 This was also supported by the C1s and O1s spectra of the COF before and after the reduction reaction. As shown in Figure 3C,E, the split C1s spectrum of the COF at −1.4 V RHE showed the decreased peak density of C═O (286.9 eV) and the occurrence of another peak belonging to C-O bonds (286.1 eV).…”

“…The cyclic voltammetry curves of COF exhibited broad redox peaks between −0.3 and 0.6 V RHE as shown in Figure 3A, which may be attributed to the reversible coordination between the carbonyl groups of COF and K + ions. The in situ ATR‐FTIR spectra (Figure 3B) scanned from 0.6 V RHE to −1.4 V RHE displayed a gradual increase at the peak of 1160 cm −1 , which can be assigned to the formation of C–O–K bonds 38,40,41 . This was also supported by the C1s and O1s spectra of the COF before and after the reduction reaction.…”

Sensitive and selective colorimetric sensing of Fe3+ion by using p-amino salicylic acid dithiocarbamate functionalized gold nanoparticles

“…In addition, we also compared the sensitivity of the present method with the reported NP-based UV-visible and fluorescence methods for detection of Fe 3+ ions (Table 1). It indicates that the present method showed higher sensitivity than the NPs-based UV-visible 41,42,44,45 and fluorescence 43,46,47 methods. Therefore, this analytical system exploits the advantages of DTC-PAS-Au NPs as colorimetric sensors for the detection of Fe 3+ by using UV-visible spectrometry.…”

The Role of Calix[n]arenes and Pillar[n]arenes in the Design of Silver Nanoparticles: Self-Assembly and Application

“…AgNPs modified by sulfonatocalixarene CA-30 with thiol groups on the lower rim were prepared [57]. Obtained AgNPs were used for detecting trace concentrations of Fe 3+ ions in aqueous medium.…”