A novel structurally simple calix[4]arene appended 8-amidoquinoline linked conjugate was synthesized and has been used as a turn-on fluorescence probe for Zn(2+) and turn off fluorescence probe for F(-). Moreover, this probe has been applied for Zn(2+) detection in blood serum upto 8.7 μM and fluoride detection upto 22 nM in waste water samples, using emission spectra.

A novel photoinduced electron transfer (PET) based substituted calix[4]arene fluoroionophore has been used for the selective recognition of tryptophan (L-Trp) and histidine (L-His) by emission spectroscopy. The detection limit of the synthesized receptor was found to be 0.00826 nM for L-Trp and 0.00158 nM for L-His. Moreover, this probe has been applied for the recognition of L-Trp and L-His from blood serum.

We developed a new, advanced, simple and non enzymatic approach for the colorimetric detection of glucose based on calix[4]arene/phenyl boronic acid (CX-PBA)functionalized gold nanoparticles (AuNPs). This molecular receptor proficiently and selectively recognizes glucose due to its ability to reversibly bind diol-containing compounds. The assembly was characterized by transmission electron micrograph (TEM), dynamic light scattering (DLS), UV-Vis, FT-IR, ESI-MS and (1)H NMR spectrometry, which demonstrates the binding affinity for glucose via a boronic acid-diol interaction. The linear range for glucose was found to be 5-100 nM with phosphate buffer pH 10, with a lower detection limit of 4.3 nM. Interference by other saccharides was negligible. The biosensor has been successfully applied to estimate the glucose in human blood serum samples and the results compared well to an automatic analyzer. With the advantages of high sensitivity, selectivity and low sample volume, this method is potentially suitable for the on-site monitoring of glucose.

Herein, we reported unique optical and electrochemical properties of citrate-stabilized gold nanoparticles (AuNPs) as a probe for smartphone-assisted, on-spot detection of codeine sulphate in toxicological screening with high sensitivity (0.9 μM).

A new fluorescence sensor has been synthesized for its selective recognition of As3+ (11.53 nM), Nd3+ (0.65 nM) and Br− (11.25 nM).

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A newly designed series of lower rim azocalix[4]arene basket type mesogens were synthesised and fully characterized. The proposed supramolecular organization displays needle shaped, rod like, focal conic and schlieren textures. These compounds were studied for their dielectric properties in the frequency range 100 Hz-2 MHz at variable temperatures (50-110 uC).