A new Secondary metabolites of the crinoid (<i>Comanthina schlegeli</i>) associated fungus <i>Alternaria brassicae</i> 93

Zhang, Liuhong; Wang, Hongwei; Xu, Jun; Li, Jing; Liu, Lan

doi:10.1080/14786419.2016.1166498

Cited by 16 publications

(3 citation statements)

References 16 publications

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“…This was the same as the performance of other research. It has been isolated in the Brassica species Comanthina schlegeli , Peucedanum japonicum , and so on, also had the extensive research value .…”

Section: Resultsmentioning

confidence: 99%

Changes of volatile organic compounds and bioactivity of Alternaria brassicae GL07 in different ages

et al. 2019

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Plant endophytes are rich in secondary metabolites and are widely used in medicine, chemical, food, agriculture, and other fields. Here, an endophytic fungus is isolated from Ginkgo biloba L. leaves and identified as Alternaria brassicae GL07 through genotypic characterizations. It can produce fruity scented volatiles. The analysis of volatile organic compounds (VOCs) was done by gas chromatography–mass spectrometry. A total of 32 components were identified; and at different culture times, the composition of VOCs was different. It had more components in the first two weeks, but a fewer components on the 21st day. More olefins, ketone, aldehyde, and alcohol were found in the growth period and more amines and esters were found in the decline period. Also, 2,5‐dihydroxyacetophenone, β‐ionone, and nonanal were found. They were the same ingredients in Ginkgo essential oils and some of them were isolated for the first time in the volatile constituents of endophytes. The antioxidant activity and whitening activities of all extracts were also evaluated. When cultured for 10 days, it had the strongest 2,2‐diphenyl‐2‐picrylhydrazyl radical (IC50, 0.56 g/L), hydroxyl radical scavenging ability (IC50, 0.47 g/L), reducing ability, and tyrosinase inhibition ability (IC50, 5.18 g/L), which may be due to a large amount of ketones and alcohols produced during the log phase. This demonstrates the potential of A. brassicae GL07 to produce bioactive compounds and to be used for perfume and cosmetic industries.

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Section: Resultsmentioning

confidence: 99%

Changes of volatile organic compounds and bioactivity of Alternaria brassicae GL07 in different ages

et al. 2019

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“…Microbial transformation is increasingly adopted as an alternative way to modify the structure of natural and synthetic compounds because of its advantages in terms of milder reaction conditions and presence of abundant enzymes along with high stereo, regio and chemo‐ selectivity over chemical synthesis. [ 47,48 ] An appropriate amount of UA strain suspended in fresh sterile broth under sterile conditions and after cultivation of microorganisms in the presence of UA, the transformed products are eventually separated through suction filtration and extraction.…”

Section: Structure Modification To Improve the Efficacy Of Uamentioning

confidence: 99%

Advances in production and structural derivatization of the promising molecule ursolic acid

Liu

Ahmad

et al. 2021

Biotechnology Journal

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Ursolic acid (UA) is a ursane‐type pentacyclic triterpenoid compound, naturally produced in plants via specialized metabolism and exhibits vast range of remarkable physiological activities and pharmacological manifestations. Owing to significant safety and efficacy in different medical conditions, UA may serve as a backbone to produce its derivatives with novel therapeutic functions. This review aims to provide ideas for exploring more diverse structures to improve UA pharmacological activity and increasing its biological yield to meet the industrial requirements by systematically reviewing the current research progress of UA. We first provides an overview of the pharmacological activities, acquisition methods and structural modifications of UA. Among them, we focused on the synthetic modifications of UA to yield valuable derivatives with enhanced therapeutic potential. Furthermore, harnessing the essential advances for green synthesis of UA and its derivatives by advent of metabolic engineering and synthetic biology are of great concern. In this regard, all pivotal advances for enhancing the production of UA have been discussed. In combination with the advantages of UA biosynthesis and transformation strategy, large‐scale microbial production of UA is a promising platform for further exploration.

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“…Biosynthesis of valuable products have advantages over chemical synthsis in terms of milder reaction conditions and presence of abundant enzymes along with high stereo-, regio-and chemo-selectivities 53 . Therefore, microbial transformation is increasingly adopted as an alternative way to modify the structure of natural and synthetic compounds 54,55 . In particular, it is easy to achieve the glycosylation of pentacyclic triterpenes that is difficult during chemical synthesis 56 .…”

Section: 2directed Transformation Of Ua By Microorganismsmentioning

confidence: 99%

Harnessing Pivotal Advances for Production and Structural Derivation of the Promising Molecule Ursolic Acid

Liu¹,

Ahmad²,

Lv³

et al. 2021

Preprint

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Ursolic acid (UA) is a ursane-type pentacyclic triterpenoid compound, naturally produced in plants via specialized metabolism and exhibits vast range of remarkable physiological activities and pharmacological manifestations. Owing to significant safety and efficacy in different medical conditions, UA may serve as a backbone to produce its derivatives with novel therapeutic functions. This review systematically provides an overview of the pharmacological activities, acquisition methods and structural modification methods of UA. In addition, we focused on the synthetic modifications of UA to yield its valuable derivatives with enhanced therapeutic potential. Furthermore, harnessing the essential advances for green synthesis of UA and its derivatives by advent of metabolic engineering and synthetic biology are highlighted. In combination with the advantages of UA biosynthesis and transformation strategy, large-scale production and applications of UA is a promising platform for further exploration.

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A new Secondary metabolites of the crinoid (Comanthina schlegeli) associated fungus Alternaria brassicae 93

Cited by 16 publications

References 16 publications

Changes of volatile organic compounds and bioactivity of Alternaria brassicae GL07 in different ages

Changes of volatile organic compounds and bioactivity of Alternaria brassicae GL07 in different ages

Advances in production and structural derivatization of the promising molecule ursolic acid

Harnessing Pivotal Advances for Production and Structural Derivation of the Promising Molecule Ursolic Acid

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