A new bisbenzyltetrahydroisoquinoline alkaloid from Berberis tabiensis (Berberidaceae)

Quevedo, Rodolfo; Valderrama, Katherine; Moreno-Murillo, Bárbara; Laverde, Marilú; Fajardo, Víctor

doi:10.1016/j.bse.2008.07.007

Cited by 15 publications

(7 citation statements)

References 9 publications

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“…Similar results have been reported in terms of the TAC for Berberis species, i.e. 506–803 mg/L as cy‐3‐glycoside, 16.32 to 91.66 mg/100 g FW, and 0.93 mg/g FW . Yildiz et al reported that TAC in fruits of B. vulgaris was between 271 and 1004 mg/L as cy‐3‐glycoside.…”

Section: Resultsmentioning

confidence: 99%

“…Also, Ozgen et al reported that total phenolic content (TPC), total anthocyanin content (TAC), and antioxidant activity by the FRAP (ferric reducing antioxidant power) assay were various among 30 barberry fruit accessions. Although many studies have been conducted on the antioxidant capacity and phytochemical compounds of stems, roots, flowers, barks, leaves of the barberry species, few studies exist on the fruits.…”

Section: Introductionmentioning

confidence: 99%

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Classification of barberry genotypes by multivariate analysis of biochemical constituents and HPLC profiles

Gholizadeh-Moghadam

Hosseini

Alirezalu

2019

Phytochemical Analysis

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Introduction Recently, there has been a growing interest in the use of edible barberry and their extracts as a source of natural antioxidants in food and pharmaceutical industries. Objective The aim of this study was to evaluate the biochemical constituents of 18 samples of barberry fruits and classification of barberry genotypes by multivariate analysis. Methods Total phenolic, total flavonoid, total anthocyanin, total tannin, total carbohydrate contents and antioxidant activity were determined using Folin–Ciocalteu, aluminum chloride, colorimetric, vanillin, anthron and DPPH (2,2′‐diphenyl‐1‐picrylhydrazyl) assays, respectively. High‐performance liquid chromatography (HPLC) system is used for quantitative determination of phytochemical constituents. The multivariate data analysis (principal component analysis and hierarchical cluster analysis) and heat map data visualisation techniques were performed to classify barberry genotypes using Minitab and GraphPad Prism software, respectively. Results The highest amounts of total phenolics and flavonoids were obtained in fruit extracts of G3 (Berberis vulgaris). The highest total anthocyanin content and antioxidant activity were observed in G8 (B. vulgaris) and G16 (B. vulgaris), respectively. HPLC analysis of phytochemicals (gallic acid, caffeic acid, chlorogenic acid, p‐coumaric acid, cinnamic acid, rutin, apigenin, and quercetin) revealed that gallic acid and p‐coumaric acid were found as the most abundant phytochemical compounds. Based on multivariate analysis and heat map visualisation techniques, Berberis genotypes were classified into three main clusters. Conclusions These results showed that barberry species (especially B. vulgaris and B. carataegina) are promising sources of natural antioxidants and biochemical compounds beneficial to be used in the food industry and that the multivariate analysis was a suitable approach to classify the barberry samples.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Classification of barberry genotypes by multivariate analysis of biochemical constituents and HPLC profiles

Gholizadeh-Moghadam

Hosseini

Alirezalu

2019

Phytochemical Analysis

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“…This head-head binding pattern has been previously observed in bisbenzylisoquinoline alkaloids having two head-head bridges between carbons C-7, C-8 0 and C-6, C-7 0 isolated from species belonging to the Menispermaceae (Chang & Wu, 2005) and Monimiaceae families (Schiff, 1997). Tabienine B is the second alkaloid presenting head-head binding between carbons C-6 and C-7 0 and is the second new alkaloid to be isolated from a species belonging to the Berberis Aequinoctiales subgroup (Chang & Wu, 2005;Quevedo et al, 2008).…”

Section: Resultsmentioning

confidence: 81%

“…Our previous studies of Berberis tabiensis LAC (Berberidaceae) alkaloid extract have afforded a bisbenzylisoquinoline alkaloid called tabienine (Quevedo, Valderrama, Moreno-Murillo, Laverde, & Fajardo, 2008). This study was part of a continuing investigation into the chemical composition and larvicidal activity of B. tabiensis stems.…”

Section: Introductionmentioning

confidence: 98%

A rare head–head binding pattern in bisbenzylisoquinoline alkaloids

Quevedo

Nuñez

Moreno

2011

Natural Product Research

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“…Berberis (Berberidaceae) posses more than 500 species and is the only genus of the family in the southern hemisphere (Bai et al 2011). The genus Berberis is full of isoquinoline alkaloids having high potential in the treatments of many ailments and insects control (Baird et al 1997;Wright et al 2000;Quevedo et al 2008). The hydro ethanolic extract of Berberis species (B. aristata, B. asiatica, B. chitria and B. lyceum) have shown very good antimicrobial efficacy against bacterial (eleven) and fungal (eight) strains (Küpeli et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Activity Guided Isolation of Nematicidal Constituents from the Roots of Berberis brevissima Jafri and Berberis parkeriana Schneid

Ali¹,

Naz²,

Alamzeb³

et al. 2019

Tarım Bilimleri Dergisi

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Biological screening of different parts of the selected Berberis species (B. brevissima Jafri and B. parkeriana Schneid) showed that methanolic root extract possessed significant efficacy against Meloidogyne javanica (a root knot nematode). From root methanolic extracts of selected Berberis species four isoquinoline alkaloids; jatrorrhizine, dehydrocheilnthifoline, berberine and berberrubine were isolated. Structures of the isolated compounds were determined by using EIMS, 1 H and 13 C NMR, and other 2D spectroscopic techniques. Percentage juveniles mortality of M. javanica was determined at various concentrations (100, 200 and 300 µg mL-1) using carbofuran as control. Berberine possessed the highest nematicidal activity (71.33%) followed by jatrorrhizine (59.50%). The in vitro results suggested that these compounds from Berberis species could be potential novel nematicides against M. javanica.

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A new bisbenzyltetrahydroisoquinoline alkaloid from Berberis tabiensis (Berberidaceae)

Cited by 15 publications

References 9 publications

Classification of barberry genotypes by multivariate analysis of biochemical constituents and HPLC profiles

Classification of barberry genotypes by multivariate analysis of biochemical constituents and HPLC profiles

A rare head–head binding pattern in bisbenzylisoquinoline alkaloids

Activity Guided Isolation of Nematicidal Constituents from the Roots of Berberis brevissima Jafri and Berberis parkeriana Schneid

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