A rare head–head binding pattern in bisbenzylisoquinoline alkaloids

Quevedo, Rodolfo; Nuñez, Lorena; Moreno, Bárbara

doi:10.1080/14786419.2010.512000

Cited by 7 publications

(2 citation statements)

References 8 publications

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“…For Berberis genus protoberberins, isoquinoline, and bisbenzylisoquinoline alkaloids were present in greater quantities in root and bark [87][88][89][90][91]. In contrast, terpenes, anthocyanins, tannins and phenolic compounds have been found in leaves and fruits of Berberis vulgaris [92,93].…”

Section: Preliminary Phytochemical Analysismentioning

confidence: 99%

Preliminary Phytochemical Analysis of Berberis goudotii Triana & Planch. ex Wedd. (Berberidaceae) with Anticariogenic and Antiperiodontal Activities

et al. 2019

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Berberis goudotii is an endemic Colombian plant found in the paramo ecosystem. It has been used in food preparation and as a medicinal plant for diverse treatments. Additionally, it is used as a mouthwash to strengthen the gums and combat throat irritations and periodontitis. The present research evaluated Berberis goudotii aerial parts extract and fractions antimicrobial activities. Ultrasonic-assisted extraction was used to attain total ethanol-water extract. Solid-liquid fractionation was used to obtain hexane fraction. The residue was dispersed in water and liquid-liquid fractionation was carried-out to acquire dichloromethane, butanol and water fractions. Preliminary phytochemical analysis was performed on total extract and phenol, polyphenol, flavonoid, and proanthocyanidin, while tannin content was quantified. Antimicrobial activity assessment was performed by agar diffusion method using disks and wells employing Ceftazidime as a positive control against Streptococcus mutans, Streptococcus sobrinus, Lactobacillus acidophilus, Lactobacillus casei, Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum. Antimicrobial activity was determined as relative percentage inhibition (RPI), minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Phenols (92.5 ± 7.7 mg GA/10 g), polyphenols (87.7 ± 8.1 mg PG/10 g) and tannins (44.1 ± 4.3 mg PG/10 g) were among the highest secondary metabolites observed. Total extract presented an MBC of 1.0 µg/µL against cariogenic bacteria (Streptococcus mutans and Streptococcus sobrinus) and 0.12 µg/µL against bacteria associated with periodontal disease (Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum). Butanol and hexane fractions showed antiperiodontal activity with MBC of 0.12 and 1.0 µg/µL, respectively. In conclusion, Berberis goudotii total extract demonstrated antimicrobial activity against cariogenic and periodontal microorganisms, on the other hand, hexane and butanol fractions displayed antiperiodontal activity.

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Section: Preliminary Phytochemical Analysismentioning

confidence: 99%

Preliminary Phytochemical Analysis of Berberis goudotii Triana & Planch. ex Wedd. (Berberidaceae) with Anticariogenic and Antiperiodontal Activities

et al. 2019

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“…Tetrahydroisoquinolines are present in many natural or synthetic organic compounds; they have varied biological activity [1][2][3][4][5]. Such compounds are usually obtained by adding a -phenylethylamine to a carbonyl compound to form an imine.…”

Section: Introductionmentioning

confidence: 99%

Heterogeneous Catalysts in Pictet‐Spengler‐Type Reactions

Quevedo

Perdomo²,

Moreno³

2012

Journal of Chemistry

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Several solid catalysts were evaluated as an alternative for 1,2,3,4-tetrahydroisoquinoline synthesis by means of the Pictet-Spengler reaction. The reaction catalysed by a mixed oxide (Mg and Al) led to the best yield and good regioselectivity; using an Al-pillared bentonite led to good yields and total regioselectivity. The results revealed no direct relationship between catalyst acidity and yield.

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Influence of Steric, Electronic, and Molecular Preorganization Effects in the Reactivity of β‐phenylethylamines with Nonenolizable Aldehydes

Quevedo

2016

Non‐covalent Interactions in the Synthesis and Design of New Compounds

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A rare head–head binding pattern in bisbenzylisoquinoline alkaloids

Cited by 7 publications

References 8 publications

Preliminary Phytochemical Analysis of Berberis goudotii Triana & Planch. ex Wedd. (Berberidaceae) with Anticariogenic and Antiperiodontal Activities

Preliminary Phytochemical Analysis of Berberis goudotii Triana & Planch. ex Wedd. (Berberidaceae) with Anticariogenic and Antiperiodontal Activities

Heterogeneous Catalysts in Pictet‐Spengler‐Type Reactions

Influence of Steric, Electronic, and Molecular Preorganization Effects in the Reactivity of β‐phenylethylamines with Nonenolizable Aldehydes

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