A nanostructured suitable platform based on multi wall carbon nanotubes and graphene nano sheets composite for determination of mefenamic acid

Abstract

A mefenamic acid sensor was prepared by the modification of a glassy carbon electrode (GCE) with graphene nano-sheets (Gr) and multi wall carbon nanotubes (MWCNT). The designed sensor (MWCNT/Gr/GCE) indicated an electrocatalytic behaviour when applied for mefenamic acid (MFA) oxidation due to good conductivity, low electron transfer resistance and catalytic effect. The suggested sensor revealed a lower overvoltage and enhanced current compared with bare GCE for the oxidation of MFA. The observations indicated that the oxidation potential of MFA is decreased more than 200 mV using the designed sensor. The percentages of MWCNTs and Gr nano materials, and pH solution were optimized. Under the optimum conditions, some kinetic parameters, such as surface coverage in a 0.5 mM [Fe(CN) 6 ] 3-/4solution was obtained by cyclic voltammetric method. The diffusion coefficient of MFA (D) was calculated to be 2.88×10-6 cm 2 s-1 by chronoamperometeric technique. The MWCNT/Gr/GCE sensor exhibited a linear dynamic range for MFA (2-100 µM) with a detection limit of 0.66 µM by differential pulse voltammetry (DPV) technique. This sensor revealed a suitable applicability for determination of MFA in real samples (drug samples and serum solutions).

Luminescent Two-Dimensional Metal–Organic Framework Nanosheets with Large π-Conjugated System: Design, Synthesis, and Detection of Anti-Inflammatory Drugs and Pesticides

“…The quenching constant ( K SV ) value was calculated to be 4.32 × 10 4 M –1 according to the experimental data, indicating a high level of quenching sensitivity and binding interaction toward DCF. The detection limit for DCF was calculated to be 0.62 μM (0.20 ppm), which is comparable to those of well-designed nanosensors. − As compared to bulk Zn-MOF with a detection limit of 7.72 ppm for DCF (Figure S13), the large surface area and ultrathin thickness can account for the highly sensitive determination of DCF by 2D Zn-MOF nanosheets. The anti-interference ability for other potential interfering analytes was also investigated.…”

Screen printed carbon electrode modified with magnetic core shell manganese ferrite nanoparticles for electrochemical detection of amlodipine

“…Nanoparticles can act as the conduction centres facilitating the transfer of electrons and provide the great catalytic surface areas. [29][30][31][32][33] SCREEN PRINTED ELECTRODE FOR AMLODIPINE DETERMINTION…”