A Multimodal Eye Assessment in Psoriatic Arthritis Patients sine-Psoriasis: Evidence for a Potential Association with Systemic Inflammation

Chimenti, Maria Sole; Triggianese, Paola; Salandri, Giorgia; Conigliaro, Paola; Canofari, Claudia; Caso, Francesco; Costa, Luisa; Nucci, Carlo Alberto; Aiello, Francesco; Cesareo, Massimo; Perricone, Roberto

doi:10.3390/jcm9030719

Cited by 12 publications

(15 citation statements)

References 46 publications

(70 reference statements)

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“…Of the 15 studies, four studies reported data on the prevalence of dry eye disease [14, 30, 33, 35]. According to the data from 555 people (303 psoriasis patients and 252 non-psoriasis controls), psoriasis patients showed a significantly higher prevalence of dry eye disease than the non-psoriasis controls (OR, 8.49, 95% CI, 3.34–21.58, p < 0.0001).…”

Section: Resultsmentioning

confidence: 99%

Psoriasis and Dry Eye Disease: A Systematic Review and Meta-Analysis

Wu¹,

Ma²,

Huang³

et al. 2022

Dermatology

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Background: Psoriasis is a chronic inflammatory skin disease with potential systemic involvement. Some evidence suggests an increased risk of dry eye in patients with psoriasis. However, the relationship between these two conditions remains unclear. The aim of our study is to investigate the association between psoriasis and dry eye disease. Methods: This meta-analysis was registered in PROSPERO (CRD42020199445) and adhered to MOOSE checklist and PRISMA guidance for all processes. PubMed, Embase, Web of Science, and Cochrane databases were searched for studies examining the association between psoriasis and dry eye disease from inception to December 13, 2020. The primary outcome was the prevalence of dry eye disease in patients with psoriasis relative to controls. The secondary outcomes were the Schirmer I test score, tear film breakup time (TBUT), and ocular surface disease index (OSDI). The risk of bias of the selected studies was assessed using the Newcastle-Ottawa Scale. Results: The meta-analysis showed a significant association between dry eye disease and psoriasis (OR, 8.49; 95% CI, 3.34–21.58). Moreover, patients with psoriasis had a significantly lower Schirmer I test score (MD, −2.80; 95% CI, −4.07 to −1.52), shorter TBUT (MD, −4.12; 95% CI, −5.22 to −3.02), and higher OSDI (MD, 20.15; 95% CI, 6.24–34.05; p < 0.01), compared to controls. Conclusions: The current evidence supports an association between dry eye disease and psoriasis. These results suggest ophthalmologic assessment for the early recognition and management of dry eye in patients with psoriasis.

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Section: Resultsmentioning

confidence: 99%

Psoriasis and Dry Eye Disease: A Systematic Review and Meta-Analysis

Wu¹,

Ma²,

Huang³

et al. 2022

Dermatology

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“…111 As with AS, anterior uveitis is the most frequent manifestation in PsA, occurring in 2–25% of cases. 112 The presence of DED in patients with PsA is mainly associated with the occurrence of concomitant PsO. However, a recent study by Chimenti et al described a significantly higher prevalence of DED, defined as a Schirmer test < 5 mm and/or a TBUT <10 s, in PsA patients without PsO compared with healthy controls.…”

Section: Dry Eye Disease and Associated Ocular Complications With Sys...mentioning

confidence: 96%

Dry eye disease, a prominent manifestation of systemic autoimmune disorders

Bustamante-Arias

Ruiz-Lozano

Rodríguez-García

2022

European Journal of Ophthalmology

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Objectives Dry eye disease (DED) is arguably the most frequent ocular disease encountered in ophthalmic clinical practice. DED is frequently an underestimated condition causing a significant impact on visual function and quality of life. Many systemic autoimmune diseases (SAIDs) are related to moderate to severe DED. The main objective of this review is to enhance the awareness among ophthalmologists of the potential association of an underlying SAID in a high-risk patient with DED. Methods An exhaustive literature search was performed in the National Library of Medicine's Pubmed, Scopus, Web of Science, and Google Scholar databases for all English language articles published until November 2021. The main keywords included “dry eye disease” associated with autoimmune, connective tissue, endocrine, gastrointestinal, hematopoietic, vascular, and pulmonary diseases. Case reports, series, letters to the editor, reviews, and original articles were included. Results Although DED is frequently associated with SAIDs, its diagnosis is commonly delayed or missed, producing significant complications, including corneal ulceration, melting, scleritis, uveitis, and optic neuritis resulting in severe complications detrimental to visual function and quality of life. SAID should be suspected in a woman, 30 to 60 years old with a family history of autoimmunity, presenting with DED symptoms and extraocular manifestations including arthralgias, dry mouth, unexplained weight and hair loss, chronic fatigue, heat or cold intolerance, insomnia, and mood disorders. Conclusions Establishing the correct diagnosis and treatment of DED associated with SAIDs is crucial to avoid its significant burden and severe ocular complications.

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“…Eye changes in patients with psoriasis are considered to be a consequence of systemic inflammation (7) and increased cytokine production; however, they are often overlooked, although their progression may result in visual impairment. Changes in the tear film, the conjunctival surface, or disruption of the meibomian glands are common among patients with psoriasis.…”

Section: Etiopathogenesismentioning

confidence: 99%

Psoriasis beyond the skin: Ophthalmological changes (Review)

et al. 2021

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Psoriasis is a chronic, immune-mediated inflammatory disease of unknown etiology that may be associated with abnormal T-lymphocyte function. Ocular manifestations associated with psoriasis, particularly artropathic or pustular psoriasis, usually affect men, often during exacerbations of the disease. It has been reported that eye damage tends to occur later compared with cutaneous or joint manifestations, blindness being the most disabling complication. Previous studies have focused on ophthalmic manifestations and identified several etiopathogenic mechanisms. Psoriasis may be associated with eye complications such as lesions of the eyelids, conjunctiva and others, with systemic inflammation being the main contributor. In addition, the treatment used for psoriasis may cause ocular changes. The main ophthalmic manifestations associated with psoriasis are keratoconjunctivitis sicca, blepharitis, conjunctivitis and uveitis. The treatment of uveitis, perceived as one of the most serious eye conditions, is controversial and has yet to be clearly determined. Thus, the aim of the present review was to emphasize the importance of regular eye examination for patients with psoriasis, either those receiving biological treatment or those not receiving treatment, in order to diagnose and manage the disease appropriately.

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A Multimodal Eye Assessment in Psoriatic Arthritis Patients sine-Psoriasis: Evidence for a Potential Association with Systemic Inflammation

Cited by 12 publications

References 46 publications

Psoriasis and Dry Eye Disease: A Systematic Review and Meta-Analysis

Psoriasis and Dry Eye Disease: A Systematic Review and Meta-Analysis

Dry eye disease, a prominent manifestation of systemic autoimmune disorders

Psoriasis beyond the skin: Ophthalmological changes (Review)

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