A microfluidic device to study effects of physical stimulation and steroid treatment on lung epithelial cell surfactant protein expression

Yeh, Sih-Ling; Lin, Ting-Ru; Peng, Chien-Chung; Liao, Wei-Hao; Tung, Yi-Chung

doi:10.1109/transducers.2017.7994377

2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS) 2017

DOI: 10.1109/transducers.2017.7994377

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A microfluidic device to study effects of physical stimulation and steroid treatment on lung epithelial cell surfactant protein expression

Sih-Ling Yeh

Ting-Ru Lin

Chien-Chung Peng

et al.

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2019

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Novel microfluidic device integrated with a fluidic‐capacitor to mimic heart beating for generation of functional liver organoids

Hirai

Kamei

et al. 2019

Elect Comm in Japan

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Liver organoids hold a great potential to understand liver development and contribute for drug screening and toxicological testing. However, conventional methods to generate organoids provide insufficient liver functions and less reproducibility, due to lack of controllability of cellular microenvironmental cues. To tackle these issues, we focus on one of the environmental cues, pressure stimuli by heart beating, and develop a microfluidic‐based cell culture platform integrating a fluidic capacitor to produce pressure stimuli with hydrostatic pressure. Furthermore, we demonstrate a numerical simulation based on equivalent circuit model for designing the device parameters with sufficient accuracy. This device concept will provide insights into physical micro‐environmental regulation on organoid development.

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Novel microfluidic device integrated with a fluidic‐capacitor to mimic heart beating for generation of functional liver organoids

Hirai

Kamei

et al. 2019

Elect Comm in Japan

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show abstract

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A microfluidic device to study effects of physical stimulation and steroid treatment on lung epithelial cell surfactant protein expression

Cited by 1 publication

References 2 publications

Novel microfluidic device integrated with a fluidic‐capacitor to mimic heart beating for generation of functional liver organoids

Novel microfluidic device integrated with a fluidic‐capacitor to mimic heart beating for generation of functional liver organoids

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