A meta-analysis on the role of brain-derived neurotrophic factor in Parkinson’s disease patients

Chen, Zhe; Zhang, Hui

doi:10.17219/acem/154955

Cited by 7 publications

(4 citation statements)

References 107 publications

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“…The studies presented provide valuable insights into the complex relationship between drug abuse, BP, dysmenorrhea, WML, FD, and SCZ. These findings contribute to our understanding of the structural and functional organization of the brain in neuropsychiatric disorders and offer potential biomarkers for early detection and personalized treatment approaches (42)(43)(44)(45). Additionally, the use of machine learning to identify brain structure patterns associated with symptoms and impairments could lead to more targeted interventions for individuals with psychiatric disorders (46-48).…”

mentioning

confidence: 93%

Editorial: Insights into structural and functional organization of the brain: evidence from neuroimaging and non-invasive brain stimulation techniques

2023

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confidence: 93%

Editorial: Insights into structural and functional organization of the brain: evidence from neuroimaging and non-invasive brain stimulation techniques

2023

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“…BDNF regulates the amount of dopamine and dopaminergic cell activity in the striatum [ 35 ], and, in turn, dopaminergic input regulates the sensitivity of striatal spiny neurons to BDNF [ 36 ]. People with PD exhibit decreased levels of BDNF in the nigrostriatal pathway, compared to neurotypical age-matched controls [ 37 , 38 ], which may leave the brain more vulnerable to degeneration [ 19 , 39 ]. It has been hypothesized that exercise-induced increase in circulating BDNF levels may serve as a therapeutic agent in PD [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Effects and Mechanisms of Exercise on Brain-Derived Neurotrophic Factor (BDNF) Levels and Clinical Outcomes in People with Parkinson’s Disease: A Systematic Review and Meta-Analysis

Kaagman,

van Wegen,

Cignetti

et al. 2024

Brain Sciences

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Introduction: Exercise therapy may increase brain-derived neurotrophic factor (BDNF) levels and improve clinical outcomes in people living with Parkinson’s disease (PD). This systematic review was performed to investigate the effect of exercise therapy on BDNF levels and clinical outcomes in human PD and to discuss mechanisms proposed by authors. Method: A search on the literature was performed on PubMed up to December 2023 using the following key words: Parkinson’s disease AND exercise, exercise therapy, neurological rehabilitation AND brain-derived neurotrophic factor, brain-derived neurotrophic factor/blood, brain-derived neurotrophic factor/cerebrospinal fluid AND randomized clinical trial, intervention study. Only randomized clinical trials comparing an exercise intervention to treatment as usual, usual care (UC), sham intervention, or no intervention were included. Results: A meta-analysis of BDNF outcomes with pooled data from five trials (N = 216 participants) resulted in a significant standardized mean difference (SMD) of 1.20 [95% CI 0.53 to 1.87; Z = 3.52, p = 0.0004, I2 = 77%], favoring exercise using motorized treadmill, Speedflex machine, rowing machine, and non-specified exercise. Significant improvements were found in Unified Parkinson’s Disease Rating Scale (UPDRS), UPDRS-III, 6 Minute Walk Test (6MWT), and Berg Balance Scale (BBS). Methodological quality of trials was categorized as “good” in three trials, “fair” in one trial, and “poor” in one trial. Conclusion: Key results of this systematic review are that exercise therapy is effective in raising serum BDNF levels and seems effective in alleviating PD motor symptoms. Exercise therapy confers neuroplastic effects on Parkinson brain, mediated, in part, by BDNF.

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“…As multiple studies have proved, BDNF could be considered a versatile biomarker in various diseases. Decreased peripheral concentrations of BDNF were observed in neuropsychiatric conditions [3][4][5][6][7][8][9][10][11], but there is a growing number of BDNF studies also in internal medicine. Low concentrations of circulating BDNF have been noted in patients with type 2 diabetes and metabolic syndrome, including obesity and dyslipidaemia [12].…”

Section: Introductionmentioning

confidence: 99%

Brain-derived neurotrophic factor serum concentration and BDNF Val66Met polymorphism in patients with peripheral artery disease: the importance of heart failure

Chyrek-Tomaszewska

Popiołek

Linkowska

et al. 2023

Medical Research Journal

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Introduction: Brain-derived neurotrophic factor (BDNF) and BDNF Val66Met polymorphism have been associated with cardiovascular diseases such as atherosclerosis, congestive heart failure (CHF), hypertension and ischaemic heart disease (IHD). To the authors' knowledge, such connections have not been described in peripheral artery disease (PAD) yet.Material and methods: 159 PAD subjects and 57 controls were included. All enrolled subjects underwent evaluation of clinical status. Information on comorbidities such as diabetes type 2, hypertension, IHD and CHF, was gathered. Serum concentrations of BDNF were measured by ELISA. Genotypes of the BDNF-AS SNP rs6265 were determined using TaqMan SNP Genotyping Assay.Results: PAD patients had significantly lower BDNF serum concentrations compared to controls (median values of 7.2 vs. 35.1 ng/mL, P < 0.001). Concentrations were significantly lower in patients with concomitant CHF (P < 0.05). The CHF subgroup was characterised by a greater prevalence of diabetes and ischaemic heart disease (P < 0.01). There was no significant difference between BDNF serum concentrations and other comorbidities, ABI, and medical history including disease duration and past interventions. No important correlations were found for BDNF Val66Met polymorphism. Conclusions:The present study adds to the body of evidence associating BDNF and atherosclerosis. The serum BDNF concentrations were lower in PAD, especially in a subgroup with comorbid CHF. These results suggest that a larger cardiovascular burden is connected with decreased BDNF serum concentrations.No evidence was found to support the hypothesis that BDNF gene polymorphism may be a contributing factor in the pathogenesis of cardiovascular diseases such as PAD.

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A meta-analysis on the role of brain-derived neurotrophic factor in Parkinson’s disease patients

Abstract: Chen Z, Zhang H. A meta-analysis on the role of brain-derived neurotrophic factor in Parkinson's disease patients [published online as ahead of print on November 18, 2022].

Cited by 7 publications

References 107 publications

Editorial: Insights into structural and functional organization of the brain: evidence from neuroimaging and non-invasive brain stimulation techniques

Editorial: Insights into structural and functional organization of the brain: evidence from neuroimaging and non-invasive brain stimulation techniques

Effects and Mechanisms of Exercise on Brain-Derived Neurotrophic Factor (BDNF) Levels and Clinical Outcomes in People with Parkinson’s Disease: A Systematic Review and Meta-Analysis

Brain-derived neurotrophic factor serum concentration and BDNF Val66Met polymorphism in patients with peripheral artery disease: the importance of heart failure

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