A Global View on Prevalence of Hypertension and Human Develop Index

Zeng, Ziqian; Chen, Jiali; Xiao, Changhong; Chen, Weizhong

doi:10.5334/aogh.2591

Cited by 48 publications

(41 citation statements)

References 13 publications

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“…42 A study conducted by Zeng et al to study the global prevalence of hypertension reported that it ranged from 13% to 41% worldwide. 43 It has been observed that hypertension is one of the prime factors in patients with atrial fibrillation (≈22%). 40,44 Study by Khurshid et al reported a prevalence of 2.35% baseline rhythm abnormality among the general population and a higher (4.84%) prevalence among population aged 65 to 73 years.…”

Section: Discussionmentioning

confidence: 99%

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Cardiovascular Adverse Events Reported from COVID-19 Vaccines: A Study Based on WHO Database

Kaur¹,

Dutta²,

Charan³

et al. 2021

IJGM

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Background: Thirteen COVID-19 vaccines are granted emergency approval. It is crucial to monitor their adverse events post vaccination. The present study focuses on cardiovascular adverse events post-COVID-19 vaccination and aims to determine adverse events with the administered vaccine. Methodology: The cardiovascular (CVS) adverse events were extracted for three broad headings (SOCs) -cardiac disorders, vascular disorders, and investigations. Descriptive statistics were reported in the form of percentage and frequency, and the disproportionality analysis was conducted. Results: For the cardiovascular system, 4863 adverse events (AEs) were reported from BNT162b2 Pfizer, 1222 AstraZeneca, Moderna, and other COVID-19 vaccines. Common adverse events observed with vaccines under study were tachycardia (16.41%), flushing (12.17%), hypertension (5.82%), hypotension (3.60%) and peripheral coldness (2.41%). Based on disproportionality analysis (IC 025 values), acute myocardial infarction, cardiac arrest, and circulatory collapse were linked to the vaccines in the age group >75 years. Hypertension, severe hypertension, supraventricular tachycardia, sinus tachycardia, and palpitations were associated across all age groups and either gender. Amongst the investigations, abnormal ECG findings raised C-reactive protein, elevated D dimer, and troponin were reported in specific age groups or gender or all subjects. Conclusion: Although cardiovascular events have been reported with the COVID-19 vaccines, the causality is yet to be established because such CVS AEs are also usually associated with the general public even without intervention. Hence, people should be administered these vaccines, and sustained monitoring of these AEs should be done.

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Section: Discussionmentioning

confidence: 99%

“… 42 A study conducted by Zeng et al to study the global prevalence of hypertension reported that it ranged from 13% to 41% worldwide. 43 …”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Adverse Events Reported from COVID-19 Vaccines: A Study Based on WHO Database

Kaur¹,

Dutta²,

Charan³

et al. 2021

IJGM

View full text Add to dashboard Cite

show abstract

“…It is well-known that hypertension is a severe public health challenge. Data have shown that the prevalence of hypertension ranged from 13 to 41% among 182 countries in the world, accounting for approximately 45% of the global cardiovascular morbidity and mortality ( Zeng et al, 2020 ). Exercise is one of the major non-pharmacological treatments for hypertension, and is broadly recommended by European and American hypertension guidelines ( Dimeo et al, 2012 ).…”

Section: Irisin and Cardiovascular Healthmentioning

confidence: 99%

Irisin: A New Code Uncover the Relationship of Skeletal Muscle and Cardiovascular Health During Exercise

Ding

Deng

et al. 2021

Front. Physiol.

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Exercise not only produces beneficial effects on muscle itself via various molecular pathways, but also mediates the interaction between muscles and other organs in an autocrine/paracrine manner through myokines, which plays a positive role in maintaining overall health. Irisin, an exercise-derived myokine, has been found involved in the regulation of some cardiovascular diseases. However, the relationship between irisin and cardiovascular health is not fully elucidated and there are some divergences on the regulation of irisin by exercise. In this review, we present the current knowledge on the origin and physiology of irisin, describe the regulation of irisin by acute and chronic exercises, and discuss the divergences of the related research results. Importantly, we discuss the role of irisin as a biomarker in the diagnosis of cardiovascular diseases and describe its treatment and molecular mechanism in some cardiovascular diseases. It is expected that irisin will be used as a therapeutic agent to combat cardiovascular diseases or other disorders caused by inactivity in the near future.

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“…Hypertension is one of the major causes of cardiovascularrelated morbidity and mortality in humans [1][2][3][4]. Epidemiological studies reported that excess dietary fructose (≥74 g/day) in the form of added sugar is associated with higher blood pressure (BP) values in adults who did not have a history of hypertension [5].…”

Section: Introductionmentioning

confidence: 99%

Methanol (80%) leaf extract of Otostegia integrifolia Benth (Lamiaceae) lowers blood pressure in rats through interference with calcium conductance

Degu

Abebe

Engidawork

2021

BMC Complement Med Ther

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Background Otostegia integrifolia Benth. (Lamiaceae) leaves are used to treat hypertension in Ethiopian folk medicine. However, the claim has so far not been investigated scientifically. Thus, the objective of this study was to evaluate the antihypertensive activity of 80% methanol leaf extract of O. integrifolia in animal model of hypertension and possible underlying mechanisms in isolated rat aorta. Methods Antihypertensive effect of various oral doses of the extract (250, 500 and 1000 mg/kg) was determined in fructose-induced hypertensive rats using the non-invasive tail-cuff method. Thoracic aortic strips of rats were isolated and suspended in organ bath, and the vasodepressor effect as well as the possible mechanism (s) of action were studied by means of isometric tension recording experiments ex vivo. Phytochemical analysis was also performed to suggest possible constituents related to the activity. Results Blood pressure was significantly lowered in a dose-dependent manner following extract administration, suggesting that the extract possesses antihypertensive activity. The extract also caused a dose-dependent relaxation of aortic strip precontracted with KCl at a concentration of 6.25–125 μg/L, with a maximum relaxation (100%) achieved at a cumulative concentration of 318.75 μg/ml. The relaxation mechanism was found to be independent of muscarinic receptors, prostanoids, histamine receptors, ATP dependent K+ channels, sarcoplasmic reticulum stored Ca2+ and the endothelium system. The extract shifted the Ca2+ concentration-response curve to the right similar to that caused by nifedipine, suggesting that vasorelaxation could possibly be mediated via calcium channel blockade. The extract was found to contain phenolic compounds (164.3 mg/g, expressed as gallic acid equivalents) and flavonoids (125.7 mg/g, expressed as quercetin equivalents). Conclusion The findings revealed that the plant is endowed with antihypertensive activity, providing evidence for its traditional use. The effect maybe, at least in part, due to dilation of blood vessels through blockade of Ca+ 2 channels mediated by phenolic and flavonoid constituents.

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A Global View on Prevalence of Hypertension and Human Develop Index

Cited by 48 publications

References 13 publications

Cardiovascular Adverse Events Reported from COVID-19 Vaccines: A Study Based on WHO Database

Cardiovascular Adverse Events Reported from COVID-19 Vaccines: A Study Based on WHO Database

Irisin: A New Code Uncover the Relationship of Skeletal Muscle and Cardiovascular Health During Exercise

Methanol (80%) leaf extract of Otostegia integrifolia Benth (Lamiaceae) lowers blood pressure in rats through interference with calcium conductance

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