Cardiovascular Adverse Events Reported from COVID-19 Vaccines: A Study Based on WHO Database

Abstract

Background: Thirteen COVID-19 vaccines are granted emergency approval. It is crucial to monitor their adverse events post vaccination. The present study focuses on cardiovascular adverse events post-COVID-19 vaccination and aims to determine adverse events with the administered vaccine. Methodology: The cardiovascular (CVS) adverse events were extracted for three broad headings (SOCs) -cardiac disorders, vascular disorders, and investigations. Descriptive statistics were reported in the form of percentage and frequency, and the disproportionality analysis was conducted. Results: For the cardiovascular system, 4863 adverse events (AEs) were reported from BNT162b2 Pfizer, 1222 AstraZeneca, Moderna, and other COVID-19 vaccines. Common adverse events observed with vaccines under study were tachycardia (16.41%), flushing (12.17%), hypertension (5.82%), hypotension (3.60%) and peripheral coldness (2.41%). Based on disproportionality analysis (IC 025 values), acute myocardial infarction, cardiac arrest, and circulatory collapse were linked to the vaccines in the age group >75 years. Hypertension, severe hypertension, supraventricular tachycardia, sinus tachycardia, and palpitations were associated across all age groups and either gender. Amongst the investigations, abnormal ECG findings raised C-reactive protein, elevated D dimer, and troponin were reported in specific age groups or gender or all subjects. Conclusion: Although cardiovascular events have been reported with the COVID-19 vaccines, the causality is yet to be established because such CVS AEs are also usually associated with the general public even without intervention. Hence, people should be administered these vaccines, and sustained monitoring of these AEs should be done.

Perceptions and Experiences of COVID-19 Vaccine Side-Effects Among Healthcare Workers in Southern Ethiopia: A Cross-Sectional Study

“…According to Moss, 32 the most common side effect is soreness at the site of injection, fatigue, headache, muscle aches, chills, joint pain, and possibly some fever. Moreover, Kaur et al 23 argued that the most common adverse events observed with the COVID-19 vaccines were tachycardia, flushing, hypertension, hypotension and peripheral coldness. Reports from DW 33 indicated that only typical vaccination reactions, such as pain at the injection site, muscle pain, headache and fatigue occurred with the vaccine from AstraZeneca and it is normal to have certain reactions after a vaccination within three (3) days of vaccination.…”

“…Currently, the only major risk identified is anaphylaxis. 21 According to Kaur et al, 23 common adverse events observed with the vaccine were tachycardia, flushing, hypertension, hypotension, and peripheral coldness.…”

Clinical characteristics and prognostic factors of myocarditis associated with the mRNA COVID‐19 vaccine

“…In contrast to these findings, several reports have described fatal clinical courses in vaccine-related myocarditis patients in databases. 8,[48][49][50] Thus, patients with worse outcomes might not have been reported, and this study's bias in data collection should also be considered. Additionally, this review does not represent the long-term prognosis of these patients.…”

Side effects following COVID-19 vaccination: A cross-sectional survey with age-related outcomes in Saudi Arabia

“…Rare events following the Oxford-AstraZeneca vaccine also included thrombotic adverse reactions [17][18][19]. Reports also proposed a possible association between COVID-19 vaccines and cardiovascular adverse events [20][21][22]. Prior research suggests that age might be an important determinant for the occurrence of the side effects after vaccination.…”