2008
DOI: 10.1111/j.1601-5223.1984.tb00110.x
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A genome mutation in three related sublines of the Ehrlich-Lettré mouse ascites tumor1,2

Abstract: Granzow, C. and Nielsén, K, 1984. A genome mutation in three related sublines of the Ehrlich‐Lettré mouse ascites tumor. —Hereditas 100:93–110. Lund, Sweden. ISSN 0018–0661. Received May 30, 1983 Whilst the Gø subline of the Ehrlich‐Lettré mouse ascites tumor (ELAT) corresponds phenotypically and cytogenetically to H. Lettrés original tumor subline, the three colchicine resistant, glycogen‐storing ELAT sublines, CR, G+, and HD33, differ from it by: (1) A reduction in stemline numbers from 46 to 40 or 41, (2) t… Show more

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Cited by 9 publications
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“…The currently prevailing theory of Nowell (Science, 1976) holds that unexplained “genetic instability” generates “variant sublines (with) changes in chromosome number” and that “clonal” progressions arise by “stepwise selection of more aggressive sublines” [ 14 ]. The literature, however, contains numerous examples of selections of “immediate” progressions [ 14 ] with multiple new chromosomes [ 7 , 15 – 18 ] - notably experimentally initiated fusions between cancers and heterologous cells [ 18 – 26 ]. Furthermore, the prevailing stepwise theory predicts stable intermediate sublines of cancers with multiple non-clonal additions of new chromosomes.…”
Section: Introductionmentioning
confidence: 99%
“…The currently prevailing theory of Nowell (Science, 1976) holds that unexplained “genetic instability” generates “variant sublines (with) changes in chromosome number” and that “clonal” progressions arise by “stepwise selection of more aggressive sublines” [ 14 ]. The literature, however, contains numerous examples of selections of “immediate” progressions [ 14 ] with multiple new chromosomes [ 7 , 15 – 18 ] - notably experimentally initiated fusions between cancers and heterologous cells [ 18 – 26 ]. Furthermore, the prevailing stepwise theory predicts stable intermediate sublines of cancers with multiple non-clonal additions of new chromosomes.…”
Section: Introductionmentioning
confidence: 99%