A mood management intervention was developed and a pilot test performed to assess its feasibility and effect on mood, drug use, and high-risk behaviors related to human immunodeficiency virus (HIV) in Spanish-speaking injection drug users. Ss were 35 Latino patients at a San Francisco methadone maintenance clinic, 11 of whom agreed to participate. From pretest and posttest interview data, difference scores were computed and analyzed between the participating and nonparticipating comparison groups. The study demonstrated the feasibility of short-term cognitive-behavioral interventions with this Spanish-speaking sample. The results suggested that the intervention moderated the depressive symptoms of the participants, including the HIV-positive patients. No significant changes were found in drug use and HIV-related high-risk behaviors.The Latino population in the United States is rapidly growing. Nine percent of the U.S. population is Latino, most under the age of 25 years (U.S. Bureau of the Census, 1991). However, Latinos are at a relatively greater risk for human immunodeficiency virus (HIV) infection, constituting 16% of all reported acquired immunodeficiency syndrome (AIDS) cases, and Latinas compose 20% of the total cases of AIDS in women. HIV infection is increasingly dispersed in Latinos by injection drug users (IDUs). According to the Centers for Disease Control (1991), more than 25% of heterosexual IDUs with AIDS are Latino. HIV infection transmission routes for male Latinos include heterosexual intravenous (IV) drug use (39%), homosexual-bisexual contact alone (11%), and homosexual-bisexual contact and IV drug use (7%). Fifty percent of