2018
DOI: 10.18632/aging.101536
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Abstract: Chronic obstructive pulmonary disease (COPD) is among the most important causes of death. Signaling systems that are relevant for tissue repair and detoxification of reactive oxygen species or xenobiotics are thought to be impaired in lungs of patients suffering from this disease. Here, we developed a simple cigarette smoke induced Drosophila model of COPD based on chronic cigarette smoke exposure that recapitulates major pathological hallmarks of the disease and thus can be used to investigate new therapeutic… Show more

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Cited by 20 publications
(31 citation statements)
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References 67 publications
(70 reference statements)
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“…Chronic obstructive pulmonary disease (COPD) and asthma are the two most common respiratory disorders, and they constitute chronic non-specific lung diseases (CNSLD) [1]. COPD and asthma share many phenotype similarities, such as airflow limitation, breathlessness, dyspnea, coughing, wheezing and chronic inflammation [2,3]. Evidence is mounting suggesting that COPD and asthma are complex multifactorial diseases, involving many environmental and genetic components [4,5].…”
Section: Introductionmentioning
confidence: 99%
“…For completeness, it should be mentioned here that the abbreviation "NAMs" is often used in toxicology to refer broadly to any non-animal technology, methodology, approach, or combination thereof that can be used to provide information on chemical hazard and risk assessment. Examples of NAMs include non-mammalian model systems, (e.g., Caenorhabditis elegans [88][89][90], Drosophila melanogaster [91][92][93], zebrafish [94][95][96] and Dictyostelium [97]) and computational (in silico) approaches [98], which indeed offer opportunities for mimicking human respiratory diseases in a predictive manner. However, the scope of the NAMs considered in our commentary includes only in vitro, non-animal cell models for the testing of OIDs.…”
Section: Limitations Of Current Preclinical Inhalation Testing Stratementioning
confidence: 99%
“…Stat92E-GFP was used to monitor the activation of the pathway [21]; the Gal4-UAS system [64] was used to target ectopic expression to the tracheal system. Gal4 drivers used were: btl-Gal4, UAS-GFP on the 3rd chromosome, and btl-Gal4, UAS-GFP on the 2nd chromosome (obtained from the Leptin group, Heidelberg, Germany); upd2-Gal4; upd3-Gal4 [60]; nach-Gal4 [30]. The UAS responders included: UAS-LacZ.nls (BDSC 3956), UAS-…”
Section: Drosophila Strains and Husbandrymentioning
confidence: 99%
“…Trachea from control and EGFR CA 3rd instar larvae were manually dissected and the qRT-PCR experiment was performed as described previously (19). rpl32 served as control.…”
Section: Qrt-pcrmentioning
confidence: 99%
“…Thus, there are various mutants as well as transgenic models available, which partly resemble chronic diseases prevalent in humans [17, 18]. In fact, D. melanogaster has been used to study pathologies related to brain function (A beta and tau pathology, Parkinson disease, Huntington disease) [19], respiratory function (asthma, chronic obstructive pulmonary disease (COPD)) [20, 21], motoric function (muscular dystrophy, amylotrophic lateral sclerosis) [22]), renal function (nephtrolithiasis) [23], gut disorders [24], diabetes [25], and heart function (cardiomyopathy) [26] as well as psychiatric disorders (ADHD, alcohol, and other addictions) [27, 28].…”
Section: Introductionmentioning
confidence: 99%