volume 10, issue 8, P2122-2135 2018
DOI: 10.18632/aging.101536
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Ruben Prange, Marcus Thiedmann, Anita Bhandari, Neha Mishra, Anupam Sinha, Robert Häsler, Philipp Rosenstiel, Karin Uliczka, Christina Wagner, Ali Önder Yildirim, Christine Fink, Thomas Roeder

Abstract: Chronic obstructive pulmonary disease (COPD) is among the most important causes of death. Signaling systems that are relevant for tissue repair and detoxification of reactive oxygen species or xenobiotics are thought to be impaired in lungs of patients suffering from this disease. Here, we developed a simple cigarette smoke induced Drosophila model of COPD based on chronic cigarette smoke exposure that recapitulates major pathological hallmarks of the disease and thus can be used to investigate new therapeutic…

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