A Concept for the Reduction of Mucosal SARS-CoV-2 Load using Hypochloric Acid Solutions

Mueller, Christian A.; Winter, Michael; Renner, Bertold

doi:10.1055/a-1467-5956

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…To date, there are only in vitro studies evaluating the virucidal effect of HClO on SARS-CoV-2. [30][31][32] SARS-CoV-2 has been detected in asymptomatic patients with the viral load reported to be similar to that in symptomatic patients. 33 Since patients with no or minimal symptoms often report for dental treatment, they are a danger to clinicians just as much as individuals with symptoms.…”

Section: Discussionmentioning

confidence: 83%

Effect of oral antiseptics on the viral load of SARS-CoV-2: A randomized controlled trial

Gül¹,

Dilsiz²,

Sağlık³

et al. 2022

Dent. Med. Probl.

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Background. In the oral cavity, which plays an important role in the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is possible to reduce the viral load of SARS-CoV-2 with antiseptics, thereby minimizing the transmission of the virus during dental procedures.Objectives. The aim of this study was to clinically evaluate the effect of the hypochlorous acid (HClO) and povidone-iodine (PVP-I) solutions on the oral viral load of SARS-CoV-2.Material and methods. This randomized controlled trial was conducted on 75 patients hospitalized in the COVID-19 ward of a local hospital. All the patients included in the study were within the first 24 h of hospitalization and the first 5 days of coronavirus disease 2019 (COVID-19) symptoms. The viral load of mouthwash samples was measured with the cycle threshold (Ct) value of SARS-CoV-2 through a realtime reverse transcription polymerase chain reaction (RT-PCR). The patients were divided into 3 groups. The effect on the patient's SARS-CoV-2 viral load was investigated after gargling the mouths and throats for 30 s with HClO, PVP-I and isotonic saline. First, a sample was taken after gargling with isotonic saline, then another sample was taken after gargling for 30 s with a particular antiseptic to determine the viral load of SARS-CoV-2. Results.Comparing the before and after mouthwash samples from all 3 groups, there were no statistically significant differences in the Ct values before and after gargling (p > 0.05). However, there were statistically significant differences in the number of negative samples after the use of HClO and PVP-I, which were positive before gargling (p < 0.05). Conclusions.In the light of the data obtained in this study, there is insufficient evidence that gargling with HClO or PVP-I reduces viral load. Taken together, these findings imply no role for antiseptics in the transmission of SARS-CoV-2 by the aerosol generated during dental procedures, or more generally, SARS-CoV-2 infection control.

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Section: Discussionmentioning

confidence: 83%

Effect of oral antiseptics on the viral load of SARS-CoV-2: A randomized controlled trial

Gül¹,

Dilsiz²,

Sağlık³

et al. 2022

Dent. Med. Probl.

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“…HOCl-soaked wound dressings are relied upon for continued delivery of the antimicrobial agent and healing enhancement over time [ 21 ], [ 144 ]. Cavity wounds that cannot be cleaned using standard irrigating solution are challenging.…”

Section: In Vivo Applications Of Hoclmentioning

confidence: 99%

Antimicrobial efficacy, mode of action and in vivo use of hypochlorous acid (HOCl) for prevention or therapeutic support of infections

Boecker¹,

Zhang

Breves

et al. 2023

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The objective is to provide a comprehensive overview of the rapidly developing field of the current state of research on in vivo use of hypochlorous acid (HOCl) to aid infection prevention and control, including naso-pharyngeal, alveolar, topical, and systemic HOCl applications. Also, examples are provided of dedicated applications in COVID-19. A brief background of HOCl’s biological and chemical specifics and its physiological role in the innate immune system is provided to understand the effect of in vivo applications in the context of the body’s own physiological defense mechanisms.

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A Concept for the Reduction of Mucosal SARS-CoV-2 Load using Hypochloric Acid Solutions

Cited by 2 publications

References 13 publications

Effect of oral antiseptics on the viral load of SARS-CoV-2: A randomized controlled trial

Effect of oral antiseptics on the viral load of SARS-CoV-2: A randomized controlled trial

Antimicrobial efficacy, mode of action and in vivo use of hypochlorous acid (HOCl) for prevention or therapeutic support of infections

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