Antimicrobial efficacy, mode of action and in vivo use of hypochlorous acid (HOCl) for prevention or therapeutic support of infections

Boecker, Dirk; Zhang, Zhentian; Breves, Roland; Herth, Felix J.F.; Krämer, Axel; Bulitta, Clemens

doi:10.3205/dgkh000433

Cited by 5 publications

(2 citation statements)

References 146 publications

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“…[1, 17,18] Our finding that the total aerobic count on HCW hands was significantly greater after the ABHR compared with respective baseline counts but was not significantly different to baseline after the novel product suggests that the novel product was more effective at dealing with transient flora acquired during patient care, which is consistent with the higher levels of efficacy achieved by hypochlorous acid than by alcohol in laboratory studies. [19] We sampled the hands of HCW immediately before they undertook hand hygiene and before direct patient care to evaluate contamination levels at baseline. We found that 4% of the 100 baseline samples grew MRSA, and none grew antibiotic-resistant Gram-negative bacteria or C. difficile.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Novel Hypochlorous Acid Based Hand Hygiene Product With Sporicidal Activity in an Inpatient Ward Setting

Otter,

Abadioru,

Sasson

et al. 2024

Preprint

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Introduction: We under took an in-use evaluation of a novel hypochlorous acid-based hand hygiene product with in vitro sporicidal efficacy in a NHS Older Persons inpatient ward setting. Methods: The novel hand hygiene product was implemented for a trial period of seven weeks commending in September 2023. Healthcare worker (HCW) hands were sampled before and after direct patient care, and after the application of either an alcohol-based handrub (ABHR) (n=50) or the novel product (n=50). Samples were cultured to quantify the total aerobic count (TAC) and presence or absence of MRSA, ESBLs, CREs, and C. difficile. Trends in weekly observational hand hygiene audit results were reviewed, and a survey of HCW views about the new product undertaken. Results: HCW hands had a significantly greater TAC after ABHR (p=0.01) but not after the novel product (p=0.11) compared with their respective baseline counts. 3% of 100 samples grew MRSA or ESBLs after application of the alcohol-based or novel hand hygiene products. No C. difficile was cultured from healthcare worker hands. There was no significant difference in observed hand hygiene compliance. The majority of HCW surveyed preferred the novel product to the alcohol-based hand hygiene product. Discussion: The novel hand hygiene product was more effective than ABHR at reducing the TAC on HCW hands. Poor hand hygiene technique may explain the identification of antibiotic-resistant bacteria on staff hands after ABHR or the novel product. We were not able to evaluate sporicidal efficacy since no C. difficile was cultured from hands.

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Section: Discussionmentioning

confidence: 99%

Evaluation of a Novel Hypochlorous Acid Based Hand Hygiene Product With Sporicidal Activity in an Inpatient Ward Setting

Otter,

Abadioru,

Sasson

et al. 2024

Preprint

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“…HOCl's potent oxidizing capability is acknowledged for its effectiveness in eliminating pathogens. However, it also leads to considerable cellular harm, evidenced by elevated levels of lipid peroxidation, protein oxidation, and DNA damage [11].…”

Section: Hypochlorous Acid (Hocl)mentioning

confidence: 99%

Role of Oxidative Stress in Periodontal Diseases

Patil,

Dhadse,

Salian

et al. 2024

Cureus

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Periodontal disease, a significant worldwide health burden, is characterized by chronic inflammation and destruction of periodontal tissues, including the cementum, periodontal ligament (PDL), alveolar bone, and gingival tissue. Recent research has linked the development and progression of periodontal disease to oxidative stress. This study provides comprehensive explanations of the mechanisms behind oxidative stress in periodontal disease, with a focus on the generation of reactive oxygen species (ROS) and their effects on periodontal tissues. Oxidative stress triggers a number of detrimental reactions, including lipid peroxidation, protein oxidation, and damage to deoxyribonucleic acid (DNA). Alveolar bone resorption, connective tissue degradation, and periodontal inflammation are further conditions exacerbated by these processes. In addition, the delicate balance between antioxidants and oxidants is upset by oxidative stress, which impairs antioxidant defense systems and exacerbates periodontal tissue damage. This review highlights the negative effects of oxidative stress and enhances periodontal health outcomes.

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