Effect of oral antiseptics on the viral load of SARS-CoV-2: A randomized controlled trial

Gül, SemaNur Sevinc; Dilsiz, Alparslan; Sağlık, İmran; Aydın, Nurten Nur

doi:10.17219/dmp/150831

Cited by 12 publications

(14 citation statements)

References 36 publications

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“…Out of these, three clinical studies were eligible for quantitative analysis [27] , [28] , [29] . The reasons for exclusion after full-text screening are reported in Table 3 [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] , [81] , [82] , [83] , [84] , [85] , [86] , [87] .…”

Section: Resultsmentioning

confidence: 99%

“… Off-topic 4 [32] , [35] , [45] , [49] 4. No longitudinal data on SARS-CoV-2 viral load in human oropharyngeal fluids and surrogates 11 [54] , [56] , [57] , [58] , [66] , [67] , [68] , [70] , [80] , [83] , [87] 5. Investigation/use of viruses or pseudoviruses different from SARS-CoV-2 5 [50] , [51] , [52] , [77] , [81] 6.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of different mouthwashes against COVID-19: A systematic review and network meta-analysis

Sbricoli,

Schiavon,

Brunello

et al. 2023

Japanese Dental Science Review

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Efficacy of different mouthwashes against COVID-19: A systematic review and network meta-analysis

Sbricoli,

Schiavon,

Brunello

et al. 2023

Japanese Dental Science Review

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“…Seven studies [ 11 , 16 – 18 , 21 , 23 , 24 ] reported the intervention effect of mouthwash on the CT value of novel coronavirus, with 260 cases in the treatment group and 145 cases in the control group. The fixed effects model (I 2 = 10.3%, P = 0.316) was used to pool the effect size, and the analysis results showed a positive effect in terms of CT value of novel coronavirus [SMD = 0.35, 95% CI (0.21, 0.50)] in the mouthwash group compared with the control group as shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of mouthwash on reducing salivary SARS-CoV-2 viral load and clinical symptoms: a systematic review and meta-analysis

Zhang,

Meng,

Duo

et al. 2023

BMC Infect Dis

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Background COVID-19 has been a public health emergency of international concern (PHEIC) for a lengthy period of time. The novel coronavirus is primarily spread via aerosols at a short distance, with infected individuals releasing large amounts of aerosols when speaking and coughing. However, there is an open question regarding whether mouthwash could effectively reduce virus transmission during the COVID-19 pandemic and support the prevention of infection among medical workers. Methods Cochrane Library, PubMed, Web of Science, and Embase databases were systematically searched from the inception of each database to January 12, 2023 for currently available randomized clinical trials (RCTs) on the effect of mouthwash on novel coronavirus load in the oral cavity in COVID-19 patients. The treatment group received mouthwash for rinsing the mouth, while the control group received a placebo or distilled water for COVID-19 patients. The primary outcomes were CT value and viral load. Odds ratios (ORs) were estimated using a random-effects model. Subgroup and sensitivity analyses were performed to minimize the bias and the impact of heterogeneity. Results Thirteen RCTs were included. Seven studies reported the intervention effect of mouthwash on the CT value of novel coronavirus. The analysis results showed that the mouthwash group had a positive impact on the CT value of novel coronavirus [ SMD = 0.35, 95% CI (0.21, 0.50)] compared with the control group. In addition, subgroup analysis showed a significant positive effect of mouthwash on CT values in the treatment group compared with the control group, with chlorhexidine (CHX) [SMD = 0.33, 95% CI (0.10, 0.56)], povidone-iodine (PVP-I) [SMD = 0.61, 95% CI (0.23, 0.99)], or hydrogen peroxide (HP) [SMD = 1.04, 95% CI (0.30, 1.78)] as an ingredient of the mouthwash. Six studies reported the intervention effect of mouthwash on the viral load, 263 cases in the treatment group and 164 cases in the control group. The analysis results showed that there was no statistical difference between the mouthwash group and the control group in the viral load of novel coronavirus [SMD = -0.06, 95% CI (-0.18, 0.05)]. In the subgroup analysis by measurement time, there were statistically significant differences between the mouthwash and control groups for CT values [SMD = 0.52, 95% CI (0.31, 0.72)] and viral load [SMD = − 0.32, 95% CI (− 0.56, − 0.07)] within 30 min of gargling. Conclusions In summary, mouthwash has some efficacy in reducing the viral load of novel coronavirus, especially within 30 min after rinsing the mouth. Mouthwash containing CHX, PVP-I and HP all had significant positive effects on CT values, and PVP-I-containing mouthwash may be a promising option to control novel coronavirus infections and relieve virus-related symptoms. However, studies on the dose and frequency of use of mouthwash for infection control are still lacking, which may limit the clinical application of mouthwash. Trial registration Protocol registration: The protocol was registered at PROSPERO (CRD42023401961).

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“…Figure 8 shows all the povidone-iodine RCTs in COVID-19, studying several other outcomes in addition to mortality (hospitalization, recovery, viral positivity, viral load, symptomatic cases, both in early and in late treatments): Figure 8. Random effects meta-analysis for all RCTs about povidone-iodine in COVID-19 [100][101][102][103][104][105][106][107][108][109][110][111][112][113][114][115][116][117]. This plot shows pooled effects, see the specific outcome analyses for individual outcomes, and the heterogeneity section [21] for discussion.…”

Section: Povidone-iodine (And Other Antiseptics For Local Use)mentioning

confidence: 99%

Neglected Effective Early Therapies against COVID-19: Focus on Functional Foods and Related Active Substances. A Review

Donzelli

2023

Preprint

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The official recommendations to manage COVID-19 in the outpatient setting focus on high-cost drugs (remdesivir, nirmatrelvir-ritonavir, molnupiravir), suffering from many problems. Therefore, one may consider also other treatments meeting these criteria: • promising effectiveness, based on favorable randomized controlled trials (RCTs) of sufficient validity. Even without definitive evidence, physicians and informed patients can consider them if they are also: • safe, to the state of knowledge • with a very favorable opportunity cost • biologically plausible/not implausible • accessible • without major commercial sponsors in the trials promoting them, and with researchers without major conflicts of interests. The main focus is on a limited group of functional foods and some their active ingredients, with further mention of other substances of different origin, yet fully meeting all the aforementioned criteria. The functional foods and substances described and discussed certainly do not cover all the known effective therapies for COVID-19 (in one case also for Long-COVID), but the only therapies proposed in this paper currently satisfy all the above criteria. The supporting scientific evidence will favor meta-analyses of RCTs that include the most definitive outcome: all-cause mortality, i.e. the outcome that most fully informed people tend to prioritize. Furthermore, the reported evidence favors clinical studies of the most valid design, i.e. RCTs.

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Effect of oral antiseptics on the viral load of SARS-CoV-2: A randomized controlled trial

Cited by 12 publications

References 36 publications

Efficacy of different mouthwashes against COVID-19: A systematic review and network meta-analysis

Efficacy of different mouthwashes against COVID-19: A systematic review and network meta-analysis

Efficacy of mouthwash on reducing salivary SARS-CoV-2 viral load and clinical symptoms: a systematic review and meta-analysis

Neglected Effective Early Therapies against COVID-19: Focus on Functional Foods and Related Active Substances. A Review

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