A Comparison of Physical, Chemical, Biological and Combined Treatments for Detoxification of Free Gossypol in Crushed Whole Cottonseed

Neto, Clemente Batista Soares; Conceição, Aparecido Almeida; Gomes, Taísa Godoy; Ribeiro, José Antônio de Aquino; Campanha, Raquel Bombarda; Barroso, Paulo Augusto Vianna; Machado, A. E. V.; Mendonça, Simone; Siqueira, Félix Gonçalves de; Miller, Robert G.

doi:10.1007/s12649-020-01290-0

Cited by 15 publications

(7 citation statements)

References 58 publications

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“…Despite that, the degradation process continues to occur due to the enzymatic activities involved in the process, as demonstrated in previous works in literature which longer fermentation processes result in complete degradation of gossypol in CSC. That corroborates to Soares-Neto [37], which indicates a series of genes and proteins from P. lecomtei BRM 044603 that could be associated with the CSC detoxification process.…”

Section: Degradation Kinetics Of Toxic Compoundssupporting

confidence: 83%

Bioactives and Extracellular Enzymes Obtained from Fermented Macrofungi Cultivated in Cotton and Jatropha Seed Cakes

et al. 2022

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This work focused on obtaining fermented oil cake (cotton or Jatropha) via macrofungi growth with potential characteristics for animal feed formulations, such as the presence of extracellular enzymes, bioactive (ergosterol and antioxidants), and detoxification of antinutritional compounds. The concentration of phorbol esters was reduced by four macrofungi in Jatropha seed cake (JSC) to non-toxic levels. At least two macrofungi efficiently degraded free gossypol in cottonseed cake (CSC). Fermentation with Coriolopsis sp. INPA1646 and Tyromyces sp. INPA1696 resulted in increased ergosterol concentrations, antioxidant activity reduction, and high activity of laccases and proteases. Bromatological analysis indicated high crude protein concentrations, with partial solubilization by fungal proteases. Fermented products from Coriolopsis sp. and Tyromyces sp. in JSC or CSC can be considered important biological inputs for monogastric and polygastric animal feed.

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Section: Degradation Kinetics Of Toxic Compoundssupporting

confidence: 83%

Bioactives and Extracellular Enzymes Obtained from Fermented Macrofungi Cultivated in Cotton and Jatropha Seed Cakes

et al. 2022

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“…Optimized fermentation of CSM by Bacillus coagulans strain S17 at 40°C for 52 h can detoxify gossypol by over 81% and cause an increase in protein content by approximately 53% (Zhang et al, 2022). Similarly, Panus lecomtei CC40 and Pleurotus ostreatus CC389 secreted laccase and manganese peroxidase enzymes that detoxify gossypol (Soares Neto et al, 2021). Furthermore, optimizing protease concentration, incubation temperature, pyrolysis time, and pH has been indicated to enhance gossypol removal.…”

Section: From Genetics To Biochemistry and Back To Genetics Brief Sto...mentioning

confidence: 99%

The nutritional and industrial significance of cottonseeds and genetic techniques in gossypol detoxification

Ninkuu,

Liu,

Zhou

et al. 2023

Plants People Planet

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Societal Impact StatementGossypol and its derivatives represent a class of toxic and immunosuppressive compounds that are naturally synthesized in cottonseed. These compounds pose several health hazards to humans and animals, such as heart and lung damage, breathing difficulties, and death in swine. In poultry, gossypol reduces egg production and slows growth. Studies have also shown that gossypol can indirectly harm humans and animals through the food chain. Although several physical and chemical approaches are adopted to reduce gossypol levels in cottonseed before food and feed processing, these techniques are expensive. Therefore, genetically regulating gossypol production in cotton could provide a cheaper alternative.SummaryCotton (Gossypium spp.), the most important fiber crop, is cultivated in over a hundred countries to provide raw materials for the growing textile industry. The seed obtained after delinting cotton is a rich source of protein with a vast potential for oil and feed production. Cottonseed oil production is estimated at 5.08 million metric tons and is expected to generate over 6.56 billion United States Dollars in revenue by 2029. The cake from defatted cottonseed is used as animal feed and food supplements. However, the contamination of gossypol in cottonseed limits its use. Gossypol ingestion impairs weight gain and causes anorexia, respiratory distress, and death under extreme exposure. This review highlights the significance of cottonseed oil and meal; the pharmacological uses and impact of gossypol; the chemistry, toxicity, and bioactivity of gossypol; and the physical and chemical methods used in gossypol removal during feed and food supplement processing. In addition, the biosynthetic pathway of gossypol and attempts to genetically transform some key regulators of this pathway to produce glandless cottonseed or reduce the gossypol levels in the seed are discussed.

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“…Still, fermentation conditions need to be further optimized to continuously ensure high detoxification efficiency of microorganisms ( Mageshwaran et al., 2018 ). In the future, it is necessary to develop strategies integrating physical, chemical, and biological methods, because their combinations can remove gossypol from CSM more safely and effectively ( Soares Neto et al., 2021 ). Of course, when cotton cultivars with glanded plants and glandless seeds are commercially grown in a large scale in the future, it will render the above-mentioned processing unnecessary.…”

Section: Detoxifying Through Postharvest Treatmentmentioning

confidence: 99%

Multiple strategies to detoxify cottonseed as human food source

Liu

Zhai

et al. 2022

Front. Plant Sci.

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A Comparison of Physical, Chemical, Biological and Combined Treatments for Detoxification of Free Gossypol in Crushed Whole Cottonseed

Cited by 15 publications

References 58 publications

Bioactives and Extracellular Enzymes Obtained from Fermented Macrofungi Cultivated in Cotton and Jatropha Seed Cakes

Bioactives and Extracellular Enzymes Obtained from Fermented Macrofungi Cultivated in Cotton and Jatropha Seed Cakes

The nutritional and industrial significance of cottonseeds and genetic techniques in gossypol detoxification

Multiple strategies to detoxify cottonseed as human food source

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