A comparison of glycated albumin and glycosylated hemoglobin for the screening of diabetes mellitus in Taiwan

Hsu, Po-Wen; Ai, Masumi; Kanda, Eiichiro; Yu, Neng-Chun; Chen, Hsiao-Lien; Chen, Huanwen; Cheng, Ming-Hui; Kohzuma, Takuji; Schaefer, Ernst J.; Yoshida, Masayuki

doi:10.1016/j.atherosclerosis.2015.07.037

Cited by 27 publications

(24 citation statements)

References 29 publications

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“…In the condition of anemia, pregnancy, postprandial hyperglycemia, and diabetes mellitus using insulin, GA is a better glycemic marker than HbA1c and this is especially indicated for diabetic patients on hemodialysis . GA is more suitable to monitor the beginning of drug therapy in DM, and also to control the dose and change of medication . GA was a better marker to evaluate the responses to treatment with insulin in type 2 diabetes mellitus patients, and it presented a greater correlation with fasting glucose than HbA 1c.…”

Section: Discussionmentioning

confidence: 99%

The association between glycated albumin, glycohemoglobin, and glycated albumin to glycohemoglobin ratio in diabetic retinopathy of prediabetes

Lee

Hsu

Lai

et al. 2019

The Kaohsiung J of Med Scie

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Prediabetes increased risk of diabetes and diabetes-related macrovascular and microvascular complication. Glycohemoglobin (HbA 1c ) is clinically used as the gold standard for glycemic control of diabetes. Glycated albumin (GA) is an early Amadori-type glycation protein between glucose and serum albumin, which changes in a shorter period of time than HbA 1c and is superior to HbA 1c in reflecting fluctuations in blood glucose. In this study, we aim to assess the predictive value of GA and glycohemoglobin (HbA1c) on a progression of diabetic retinopathy (DR) in prediabetic patients in Taiwan. This study was conducted at the outpatient department of a regional hospital in Southern Taiwan, and recruited 291 patients with prediabetes from January 2016 to February 2017. Blood and urine samples were obtained from all patients after fasting for 12 hours within 1 month of enrollment. The mean age is 62.5 ± 13.0 years and there are 161 males and 130 females. A total of 24.1% of patients have DR. The average value of GA and HbA1c are 14.6% ± 2.8% and 6.0% ± 0.4%, respectively. Old age, male, high systolic blood pressure, high HbA 1C , and low total cholesterol are significantly associated with DR in patients with pre-DM. Therefore, in the prediabetic populations, high HbA 1C, but not GA nor GA/HbA 1C ratio, is significantly associated with DR. K E Y W O R D Sglycated albumin, HbA1c, prediabetes, retinopathy

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Section: Discussionmentioning

confidence: 99%

The association between glycated albumin, glycohemoglobin, and glycated albumin to glycohemoglobin ratio in diabetic retinopathy of prediabetes

Lee

Hsu

Lai

et al. 2019

The Kaohsiung J of Med Scie

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show abstract

“…We recruited normal, prediabetic, and diabetic subjects from participants after testing and participation in a standard health examination as previously described 34) . Subjects were classified as normal if their fasting serum glucose value was < 100 mg/dL, as prediabetic if their value was in the 100–125 mg/dL range, and as diabetic if their value was > 125 mg/dL using the standard criteria.…”

Section: Methodsmentioning

confidence: 99%

Lipoprotein Subfractions and Glucose Homeostasis in Prediabetes and Diabetes in Taiwan

Hsu

Cheng

et al. 2019

JAT

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Aims: Prediabetes and diabetes are associated with increased insulin resistance and decreased insulin production, dyslipidemia, and increased cardiovascular disease (CVD) risk. Our goals were to assess lipoprotein subfractions using novel assays in such subjects.Methods: Fasting normal, prediabetic, and diabetic Taiwanese men and women (n = 2,049) had their serum glucose, glycosylated hemoglobin, insulin, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), HDL3-C, apolipoprotein E-HDL-C, direct low-density lipoprotein cholesterol (LDL-C), small dense LDL-C (sdLDL-C), LDL-TG, and remnant lipoprotein cholesterol (RLP-C) levels measured using novel assays. HDL2-C, LDL-C, and large-buoyant LDL-C (lbLDL-C) were calculated.Results: Prediabetic male and female subjects had significantly higher levels of TG, RLP-C, sdLDL-C, the sdLDL-C/LDL-C ratio, and LDL-TG than normal subjects, and statin treatment abolished this effect in men, but not in women. Diabetic male and female subjects had significantly higher TG and sdLDL-C/LDL-C ratios, and significantly lower levels of HDL-C, HDL2-C, HDL3-C, and apoE HDL-C than normal subjects, as did prediabetic women. Median direct LDL-C levels were > 100 mg/dL in all groups, even in those receiving statin therapy. Calculated LDL-C significantly underestimated direct LDL-C by > 10% in diabetic subjects.Conclusions: Our data indicate that prediabetic subjects were more likely to have significantly elevated RLP-C, sdLDL-C, and LDL-TG, while diabetic subjects were more likely to have significantly decreased HDL-C, HDL2-C, HDL3-C, and apoE HDL-C than normal subjects, and calculated LDL-C significantly underestimated their direct LDL-C. In our view, direct LDL-C and sdLDL-C should be measured and optimized in both diabetic and prediabetic subjects to reduce CVD risk.

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“…Wang et al (2016) studied 206 types 2 DM patients in China and found a similar serum GA level with the Taiwan study, which is 17,9 (5,9) %. Characteristic of the patient in both studies are identical [18], [22].…”

Section: Serum Glycated Albumin Level In Type 2 Dm Patientsmentioning

confidence: 90%

“…This marker has a double role in type 2 DM complications. Besides acting as a glycation marker, GA also acts directly as an agent that cause various complications of diabetes, for instance, nephropathy, atherosclerosis, and diabetic retinopathy [22].…”

Section: Serum Glycated Albumin Level In Type 2 Dm Patientsmentioning

confidence: 99%

Correlation between Uncontrolled Blood Glucose and Oxidative Stress with Urinary Nephrin Level in Type 2 Diabetes Mellitus

Aprilia¹,

Angraeni²,

Decroli³

et al. 2019

Proceedings of the Proceedings of the 1st EAI International Conference on Medical and Health Research, ICoMHER November 13-14th

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Diabetes mellitus (DM) is one of the world's health problem with increasing prevalence and important medical and social impacts. Diabetes mellitus causes micro and macrovascular complications depending on the presence of blood glucose level disorder. Impaired glucose levels have two components, chronic hyperglycemia and acute fluctuations of blood glucose levels from peak to nadir. These two components cause DM with two main mechanisms, protein glycation, and oxidative stress. Glycated albumin describes uncontrolled medium range glucose level while malondialdehyde reflects oxidative stress. Nephrin is one of the damage markers of podocyte that represents diabetic kidney disease. To find out the correlation between uncontrolled blood glucose with urinary nephrin level in a patient with type 2 diabetes mellitus. This is an observational study with the cross-sectional method. Subjects are 30 types 2 DM patients. Patients serum glycated albumin (GA) are measured, along with serum malondialdehyde (MDA) and urinary nephrin. Among 30 types 2 DM patients, there is a significant increase in GA and MDA level. Mean serum GA level is 20,87% (5,91) %, serum MDA level is 9,24 (5,59-13,59) and urinary nephrin is 369,25 (6-3952) ng/ml. There is a moderate correlation between serum GA with urinary nephrin (p=0,027) and moderate correlation between serum MDA and urinary nephrin (p=0,003). There is a correlation between uncontrolled blood glucose with urinary nephrin level in type 2 diabetes mellitus.

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A comparison of glycated albumin and glycosylated hemoglobin for the screening of diabetes mellitus in Taiwan

Cited by 27 publications

References 29 publications

The association between glycated albumin, glycohemoglobin, and glycated albumin to glycohemoglobin ratio in diabetic retinopathy of prediabetes

The association between glycated albumin, glycohemoglobin, and glycated albumin to glycohemoglobin ratio in diabetic retinopathy of prediabetes

Lipoprotein Subfractions and Glucose Homeostasis in Prediabetes and Diabetes in Taiwan

Correlation between Uncontrolled Blood Glucose and Oxidative Stress with Urinary Nephrin Level in Type 2 Diabetes Mellitus

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