A Comparative Study of Anti-Phosphatidyl Inositole Antibodies in Patients With Myocardial Infarction and Healthy Subjects

Jahromi,

doi:10.3844/ajisp.2014.10.13

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…The Cardiovascular Disease (CVD) is one of the most important causes of mortality in the world and the burden of this disease is increasing in all developing countries (Ebrahsim and Davey-Smith, 2001; Boutayeb and Boutayeb, 2005). Smoking, high blood pressure, lipid disorder, diabetes mellitus (Almdal et al, 2004;Tang et al, 2004;Murphy et al, 2009;Amarenco et al, 2010;Willey et al, 2009), infectious disease such as mycoplasma pneumonia (Pourahmad et al, 2009), low serum adiponectin level (Shojaie et al, 2009a) and inflammation (Jahromi et al, 2010a), low serum level of Annexin-V (Shojaie et al, 2009b) and antiphospholipid antibodies (Jahromi et al, 2013a;2013b;2013c;Shojaei et al, 2011;Jahromi et al, 2010b;2014), are fundamental risk factors of heart disease. In a cohort study, the increased one standard deviation in systolic blood pressure was associated with 35% increment of risk of CVD (Hadaegh et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Gender Differences in the Prevalence of Cardiovascular Risk Factors in an Iranian Urban Population

Shojaei¹,

Jahromi²,

Rahmanian³

et al. 2015

OnLine Journal of Biological Sciences

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In Iran, more than 40% of mortality is a result of cardiovascular disorders. The aim of this study was compare of cardiovascular risk factors in urban men and women. This cross-sectional analytic study was performed in urban population of Jahrom in 2008-2009. Subjects aged 30 years or older were selected by multi stage random sampling. Serum lipids including total cholesterol, triglyceride, HDL and LDL cholesterol and also fasting blood sugar were measured. Their blood pressure was measured under standard method. Weight and height were measured with light clothes and without shoes. The most prevalent cardiovascular risk factors in men were overweight (41.3%) and hypertension (35.1%) and in women were low HDL cholesterol (51.3%) and overweight (44.4%). The prevalence of obesity and low HDL cholesterol was higher and the prevalence of smoking was lower in women than in men (p<0.001). According to our results, the prevalence of risk factors was high in both genders. So the importance of performing interventional programs such as changes of lifestyle and dietary habits are needed to reduce the risk of cardiovascular diseases.

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Section: Introductionmentioning

confidence: 99%

Gender Differences in the Prevalence of Cardiovascular Risk Factors in an Iranian Urban Population

Shojaei¹,

Jahromi²,

Rahmanian³

et al. 2015

OnLine Journal of Biological Sciences

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“…Furthermore, there is a correlation between exercise and the expression of other cytokines, e.g. endurance training may affect the serum levels of TNFα and IFNγ in men [47].…”

Section: Discussionmentioning

confidence: 99%

The effect of endurance training and testosterone supplementation on the expression of blood spinal cord barrier proteins in rats

et al. 2019

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The present study aimed to estimate the effect of endurance training, two doses of testosterone, and the combination of these stimuli on the level of the endothelial proteins claudin, occludin, JAM-1, VE-cadherin, ZO-1, ZO-2, and P-glycoprotein in rat spinal cords. Adult male Wistar rats were trained using a motor-driven treadmill for 6 weeks (40–60 min, 5 times per week) and/or were treated for 6 weeks with two doses of testosterone (i.m.; 8 mg/kg or 80 mg/kg body weight). Spinal cords were collected 48 hours after the last training cycle and stored at -80°C. The levels of selected proteins in whole tissue lysates of the spinal cord were measured by western blot. Testosterone-treated trained rats had significantly lower claudin levels than vehicle-treated trained rats. High doses of testosterone resulted in a significant decrease in claudin-5 in untrained rats compared to the control group. Both doses of testosterone significantly reduced occludin levels compared to those in vehicle-treated untrained rats. The JAM-1 level in the spinal cords of both trained and untrained animals receiving testosterone was decreased in a dose-dependent manner. The JAM-1 level in the trained group treated with high doses of testosterone was significantly higher than that in the untrained rats treated with 80 mg/kg of testosterone. VE-cadherin levels were decreased in all groups receiving testosterone regardless of endurance training and were also diminished in the vehicle-treated group compared to the control group. Testosterone treatment did not exert a significant effect on ZO-1 protein levels. Testosterone and/or training had no significant effects on ZO-2 protein levels in the rat spinal cords. Endurance training increased P-glycoprotein levels in the rat spinal cords. The results suggest that an excessive supply of testosterone may adversely impact the expression of endothelial proteins in the central nervous system, which, in turn, may affect the blood-brain barrier function.

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“…There are different pathways that play roles in atherosclerotic plaque formation. Genetics and environmental factors are important ones such as family history, obesity, hyperlipidemia, diabetes mellitus, inflammation and hypertension ( Shea et al, 1984 ; Godfrey et al, 1994 ; Thom et al, 2006 ; Shojaie et al, 2009 ; Shojaie et al, 2009 ; Jahromi et al, 2013 ; Jahromi et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Lack of Association Between rs17568 Polymorphism in OX40 Gene and Myocardial Infarction, Southern of Iran

Maalhagh¹,

Shojaei²,

Erfanian³

et al. 2015

GJHS

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Tumor necrosis factor (TNF) is one of the inflammatory cytokines which has an important role in inflammation and migration of other inflammatory cells to the atherosclerotic plaques. OX40 is a member of the TNF super family receptor protein. OX40 and OX40 ligand are co-stimulators for T-cells and can increase inflammatory response in atherosclerotic plaques. The aim of this study was to determine the association of rs17568 polymorphism in OX40 gene with premature myocardial infarction. This case control study was done on 100 patients with premature acute myocardial infarction (AMI) and a similar number of sex, age and some other cardiovascular risk factor matched healthy people. The OX40 rs17568 polymorphism was genotyped, using PCR-RFLP method. A-allele frequency of rs17568 SNP was lower non-significantly in Premature AMI, compared to healthy subjects (49% vs. 51%). The analysis of rs17568 (A/G) polymorphism showed an odds ratio of 1.127 (95% CI: 0.635-1.999; P= 0.686) for the GG genotype and 5.761 (95% CI: 1.200-27.655; P= 0.029) for the AG genotype, compared to the AA genotype. The results of this study indicate that the rs17568 SNP of OX40 gene is not associated with premature AMI in the evaluated population.

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A Comparative Study of Anti-Phosphatidyl Inositole Antibodies in Patients With Myocardial Infarction and Healthy Subjects

Cited by 3 publications

References 18 publications

Gender Differences in the Prevalence of Cardiovascular Risk Factors in an Iranian Urban Population

Gender Differences in the Prevalence of Cardiovascular Risk Factors in an Iranian Urban Population

The effect of endurance training and testosterone supplementation on the expression of blood spinal cord barrier proteins in rats

Lack of Association Between rs17568 Polymorphism in OX40 Gene and Myocardial Infarction, Southern of Iran

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